Fatty liver--clinical features and possible etiology.
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Biomedical subjects
Publications and source records attributed to T Z Lodi.
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The frequency of Hepatitis Bs antigen and antibody was determined in healthy subjects and patients with acute and chronic liver disease. The frequency of HBs Ag in healthy subjects was 2.9% and HBs Ab 35%. The high prevalence of antibody in normal individuals suggests a constant non-parenteral sub-clinical exposure to hepatitis virus. Thirty-three per cent patients with acute viral hepatitis, 20% with cirrhosis and 10% with hepatocellular carcinoma were HBs Ag positive, while HBs Ab was detected in 22% cases of acute viral hepatitis and 37% with other liver disorders. This pattern of prevalence of HBs Ab suggests that hepatitis B virus may be an important etiological agent in acute and chronic liver disease in Pakistan.
A preliminary survey of HBsAg subtypes shows that ayw is the most common subtype in Pakistan. adw. was detected in one blood donor and ayr in a Baluchi female with acute viral hepatitis.
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The number of rosette forming T cells was significantly reduced in patients with acute viral hepatitis, cirrhosis of the liver and liver cancer. The frequency of T cells in various hepatic disorders correlated well with the impairment of delayed hypersensitivity response to DNCB.
Levels of immunoglobulins in serum were determined in 41 healthy subjects and 128 professional blood donors. In healthy subjects mean levels +/- S.D. were: IgG 1260 +/- 492.9 mg/dl, IgM 62.4 +/- 18.2 mg/dl, and IgA 183.4 +/- 70.1 mg/dl. Of 128 blood donors 112 were hepatitis Bs antigen (HBsAg) negative and 16 were positive. A significant (P is less than 0.001) elevation of all three immunoglobulins was observed in HBsAg positive group suggesting increased antibody formation due to persistance of antigen.
Serum immunoglobulins were determined in 39 healthy subjects and 55 patients with a variety of acute and chronic liver diseases. Elevation of IgG and IgA was frequently observed in healthy subjects and patients with acute viral hepatitis, liver cancer and miscellaneous liver disorders. IgG and IgM were elevated in cirrhosis of the liver.
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Clinical examination and liver function tests of 14 HBAg positive and 8 HBAg negative blood donors were done. A history of Jaundice, contact with hepatitis and hepatosplenomegaly were more frequently observed in the antigen positive donors.
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