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T Zabow

Publications and source records attributed to T Zabow.

22 records · Page 2Linked to original sources
PubMed1975

An investigation of clozapine in the treatment of acute and chronic schizophrenia and gross behaviour disorders.

Fifty-two mental hospital cases of acute and chronic schizophrenia and gross behaviour disorders were investigated and observed for 6-12 months during treatment with clozapine. Three-quarters of the acute cases recovered with full occupation capacity. Two-thirds of the chronic cases improved markedly. Antisocial behaviour was controlled in 12 out of the 13 behaviour-disordered group. The improvement in initiative and social capacity was striking and appeared to be due to improved awareness of the environment and the acquisition and handling of useful knowledge. The response to clozapine appears to be specific and relapses occurred when maintenance medication was stopped. It is of value in treating temper states in epilepsy and has the advantage of not causing extrapyramidal symptoms and side-effects are slight after the first week. Maximum improvement may not be reached before 8 weeks. Thereafter the maintenance dose can be small and fluctuations in the illness do not seem to occur. The dosage, side-effects and precautions are discussed. A rating system to display the effect of clozapine on individual parameters as well as on the over-all state was devised for this study.

Acute Disease↗
PubMed1975

The effect of prolonged lithium carbonate administration on the thyrotrophin and prolactin response to thyrotrophin-releasing hormone.

Thyrotrophin (TSH) and prolactin (PRL) responses to intravenous thyrotrophin-releasing hormone (TRH) were measured in euthyroid patients suffering from psychiatric disease on long-term lithium carbonate (LC) and phenothiazine therapy. These responses were retested after oral tri-iodothyronine (T3) 120 mug/day had been given for a week. The raised basal TSH and the suppression of the exaggerated responses to TRH by T3 found in some of the patients suggest a mild disturbance of thyroid function in patients on long-term LC therapy, even in the face of clinical euthyroidism and otherwise normal thyroid function. Basal serum PRL levels and the responses to TRH were elevated in 2 of 5 patients, probably associated with phenothiazine administration. In all 5, a moderate blunting of the PRL responses after TRH was produced by T3. The suppressive effect of T3 on TRH-induced PRL responses was unexpected and suggests a modifying role of thyroid hormones on PRL secretion, although further studies are needed to confirm this possibility.

Female↗