Biomedical subjects
Publications and source records attributed to T Zileli.
We describe a patient with localized scleroderma in association with homolateral atrophy of the tongue and marked ipsilateral facial hemiatrophy which was confirmed histologically. CT scan coronal sections of the face showed severe atrophy of the tongue and facial muscles. The EMG studies failed to demonstrate a neurogenic or myogenic process.
Forty rats under urethane anesthesia were subjected to cerebral ischemia by ligation of the right carotid, the right plus the left carotid, or the right carotid plus two vertebral arteries. Ischemia caused three types of changes in the field potential of the right hippocampal CA1 region evoked by fimbrial stimulation: 1) completely reversible deterioration (57% and 16% of the rats with unilateral and bilateral carotid artery ligation, respectively), 2) moderate deterioration (37% and 24% of the rats with unilateral and bilateral carotid artery ligation) and 3) irreversible loss of the evoked activity (6% and 60% of the rats with unilateral and bilateral carotid artery ligation and all the rats subjected to three-vessel occlusion). Naloxone improved the moderate deterioration in 10 of 11 rats (1-3 mg/kg i.v.) and in 15 of 16 (50-150 nA) iontophoretic applications, but naloxone did not restore the lost evoked activity. Intravenous morphine (10 mg/kg) aggravated the ischemic changes, and this effect was reversed by naloxone, while iontophoretic administration of morphine caused only excitation. These findings suggest that naloxone has a favorable effect on cerebral ischemia not severe enough to cause transmission failure. The reversal of ischemic changes by iontophoretic naloxone indicates that its site of action is at the neuronal or microcirculatory level.
Optic neuropathy in Behçet's disease is rare, despite wide ocular and neurological involvement. Progressive atrophy of the optic disc and severe visual loss is not uncommon in Behçet's disease; however, visual loss due to acute optic neuropathy is less well known. We report three cases of optic neuropathy in Behçet's disease. The clinical picture was variable in our patients, presenting either as acute retrobulbar optic neuritis or anterior optic neuropathy. It is interesting to note that although the neurological picture resembles multiple sclerosis, there seems to be less predilection to optic nerve involvement in Behçet's disease.
Central nervous system complication of Behçet's disease are well recognized. However, peripheral nervous system involvement has been rarely observed. A case of Behçet's disease with prominent peripheral nervous system involvement is reported in this article. The results of clinical, electromyographic, immunologic and electron-microscopic findings of a nerve biopsy are presented and discussed in the light of the literature.
Neuroparalytic accidents due to sample type rabies vaccination are still an important problem in our country. We present seven patients with ascending polyneuritis, due to rabies vaccine, treated between 1982-1986, and discuss the importance of the problem.
Paroxysmal localized hyperhidrosis is a rare sign of a disorder of the autonomic nervous system. It has been reported in association with peripheral nerve, spinal cord and hypothalamic lesions and in some cases the etiology is unidentified. We present 12 cases of idiopathic paroxysmal localized hyperhidrosis and discuss the therapeutic effect and possible mechanism of clonidine which is a specific central nervous system alpha 2--adrenergic receptor agonist.
A 18 year-old boy, without a previous history, presented with psychomotor seizures and, 4 months after, mental deterioration. EEG showed focal epileptic abnormalities characterized by high amplitude spike waves in the left temporal region. Periodic complexes appeared after administration of Diazepam. CT scan showed mild cortical atrophy in the left temporal region. Measles virus HI antibody titers were 1/2048 in the serum and 1/64 in the CSF. The patient died one year after the first complex partial seizures.
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In this paper, a fatal Cryptococcus meningitis has been reported. This type of meningitis is quite rare in this country.
A 26-year-old man with the diagnosis of paroxysmal nocturnal hemoglobinuria presented with papilledema due to increased intracranial pressure without localizing neurological signs. It is concluded that papilledema and benign intracranial hypertension could result from a cerebral vein thrombosis which can complicate the course of paroxysmal nocturnal hemoglobinuria. This has not been a well-recognized feature of the disease.
Six patients with Behçet's syndrome (five male, one female) had intracranial hypertension diagnosed by elevated CSF pressure in the presence of normal or small ventricles. All six patients had headaches and papilledema. Histories included oral ulcers in 5 patients, genital ulcers in 3, uveitis in 1, arthralgia in 4, and thrombophlebitis in 3. One patient had obstruction of the superior vena cava. A filling defect in the superior sagittal sinus was shown in two patients by carotid angiography, and cerebral circulation time was prolonged in one patient. Papilledema and intracranial hypertension as a result of cerebral vein thrombosis can be initial manifestations of Behçet's syndrome. This has not been a well-recognized feature of the syndrome.
In a case of Wilson's disease with flapping tremor, computed tomography demonstrated bilateral low-density areas in the thalamocapsular regions. Computed tomographic findings in Wilson's disease are discussed.
A total of 192 retrograde jugular venographies were performed in 163 cases. The lateral and occipital sinus variations in the confluent sinuum were classified in five groups by Kalbag [21]. Additional variations of the lateral and occipital sinuses in the confluent sinuum were discovered in this study.
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Explore the source record for details and available documents.
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The EEGs of 111 children under the age of 16, and 21 adults after a head injury with a linear skull fracture were reviewed. From our results it can be concluded that linear skull fractures do not add any significant abnormality or any variation to what is stated for EEGs of minimal to mild concussions.