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T Zweighaft

Publications and source records attributed to T Zweighaft.

5 recordsLinked to original sources
PubMed1982

Treatment of Group A streptococcal pharyngitis in children. Results of a prospective, randomized study of four antimicrobial agents.

Penicillin V, benzathine/procaine penicillin G, cefadroxil monohydrate, and erythromycin estolate were randomly assigned for therapy of group A streptococcal pharyngitis in 198 children. All patients improved with in 24 hours of initiating therapy. Reinfection with a new group A streptococcal serotype occurred in 13 patients, 12 developing 7 to 12 days after stopping therapy and 11 becoming symptomatic. Relapse with the same organism occurred in 16 patients, only 5 (31%) of whom were symptomatic. Antibody titer rises, antibiotic resistance of group A organisms, presence of penicillinase-producing staphylococci, and lack of compliance were not related to recurrent infections. There were no significant differences between the failure rates of the four test drugs: penicillin V, 12%; benzathine/procaine penicillin G, 12%; cefadroxil monohydrate, 5%; and erythromycin, 2%.

Adolescent↗
PubMed1979

Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.

Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of pneumococcus and three of meningococcus. Additive effects were noted against 14 isolates of pneumococcus and 5 of meningococcus. There was no relationship between the minimal inhibitory or bactericidal concentrations for the isolates and the occurrence of antagonistic, additive, or synergistic effects. These data indicate that ampicillin and chloramphenicol may be antagonistic in vitro against some strains of pneumococcus or meningococcus.

Ampicillin↗
PubMedDate not supplied

Comparative pharmacokinetics of bacampicillin and ampicillin suspensions in infants and children.

The pharmacokinetics of ampicillin and two preparations of bacampicillin, Veegum and microcapsules, were studied in 24 infants and children. For bacampicillin, mean peak concentrations of 7.6 and 14.4 micrograms/ml were found in the sera of fasting patients after administration of 27.8 mg of drug/ml in Veegum and microcapsular suspensions, respectively. Bacampicillin (27.8 mg/kg) and ampicillin (25 mg/kg) were compared in crossover fashion in 21 of the 24 children. Although the dosage of bacampicillin was 25% smaller on an equimolar basis than that of ampicillin, drug concentrations in serum were consistently higher with bacampicillin than with ampicillin; the differences were statistically significant 0.5, 1, and 2 hr after administration. The bioavailability of bacampicillin was two-to threefold greater than that of ampicillin. Urinary concentrations of drug were twofold higher with bacampicillin than with ampicillin. The proportion of saliva samples with detectable antimicrobial activity was similar among patients who received bacampicillin (31%) and those who received ampicillin (25%); however, the mean salivary concentrations 2 and 4 hr after administration of bacampicillin were substantially higher than those after ampicillin.

Adult↗