Biomedical subjects

Tadeusz Michno

Publications and source records attributed to Tadeusz Michno.

3 recordsLinked to original sources

PubMed2002

[Activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R) and superoxide dismutase (SOD-1) in single brain metastasis].

The aim of the study was to evaluate the activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R) and superoxide dysmutase (SOD-1) in the single brain metastases. The activity of the GSH-Px was evaluated with the use of spectrophotometry, GSSG-R was evaluated basing on the method of Mize and Langdon and SOD-1 with Sykes et al. method. The examinations were carried out in 36 specimens (10 specimens of healthy brain tissue, 12 specimens of brain metastases, 14 specimens of glioma multiforme). The statistical analysis revealed significant increase (p < 0.001) of GSH-Px and GSSG-R activity within the single brain metastases in comparison with the healthy brain tissue.

Brain Neoplasms↗

PubMed2002

The decrease in antioxidant potential in human brain tumours.

UNLABELLED: The objective of our research was to estimate the activity of superoxide dismutase (SOD-1), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R), as well as the concentrations of free oxygen radicals "sweepers" (GSH, Vit.C) and the concentrations of the substances reacting with thiobarbituric acid in brain tumours with II, III and IV level of biological malignancy. The research was conducted on 61 samples obtained from the patients operated in the Department of Neurosurgery of the Medical Academy of Białystok between the years 1996 and 2000. The obtained values of the above enzyme activities and of the concentrations of the examined substances in brain tumours were compared to the adequate values determined in 10 samples of histopathologically unchanged nerve tissue. THE RESULTS: the increase of all enzymes activities in brain tumours is statistically significant (p < 0.05) as compared to the adequate activity level in normal nerve tissue. The significant decrease (p < 0.05) of the GSH and ascorbate concentration and the significant increase (p < 0.05) of the level of the thiobarbituric acid--reactive substances in the examined brain tumours was found in comparison to the adequate concentration of the above substances in normal nerve tissue.

Antioxidants↗

PubMedDate not supplied

[Evaluation of surgical treatment results in extreme lateral lumbar disc prolapsed after 12 months of follow-up].

In 1988-1997, patients with extreme lateral disc prolaps (KBWJM) were operated on the Department of Neurosurgery Medical Academy of Białystok. Females accounted for 4.9% (2 cases) and 95.1% were males (39 cases) with age range 41-60 years. During a study of clinical state 12 months after the operation, we found in 75.6% of patients good and very good results of the surgical treatment of KBWJM. During that period of time, two patients (4.9%) were reoperated out of 41 all patients.

Adult↗