Biomedical subjects

Takeo Matsuno

Publications and source records attributed to Takeo Matsuno.

At least 19 recordsLinked to original sources

PubMed2006

Tight fit technique in primary hybrid total hip arthroplasty for patients with hip dysplasia.

This article presents the midterm results of hybrid total hip arthroplasty for patients with hip dysplasia by use of a tight fit technique for the femoral component. We followed up 113 hips in 99 patients for a mean of 11 years. All final femoral rasps used in this study overrasped by 0.5 to 1.0 mm for stem insertion, resulting in relatively thin cement mantles. Both components of one hip were removed because of infection. The other 5 acetabular components were revised for osteolysis, recurrent dislocation, or dislodgement of the polyethylene liner. No femoral component was revised for aseptic loosening. We conclude that the tight fit technique using a canal-filling stem may produce good long-term results for patients with hip dysplasia.

Adult↗

PubMed2006

A prospective study of de novo scoliosis in a community based cohort.

STUDY DESIGN: A 12-year prospective study of de novo scoliosis in a community based cohort. OBJECTIVE.: To investigate factors associated with development of de novo scoliosis. SUMMARY OF BACKGROUND DATA: De novo scoliosis is becoming one of the most prevalent findings in the aging spine, and this condition is associated not only with severe back or leg symptoms but also with complicated surgical outcomes. Cross-sectional studies were limited in distinguishing de novo scoliosis from preexisting deformities, and there had been controversies over the etiology of degenerative scoliosis. METHODS: Community based volunteers were recruited, then examined by orthopedic physicians. Radiologic measurements using entire spine radiographs included the angle of scoliosis and sagittal spinal curvatures, sagittal spinal balance, grade of bone atrophy, number of degenerated discs, and vertebral fractures. We defined radiologic parameters, the disc index, and lateral osteophyte difference to evaluate the asymmetrical spinal degeneration. RESULTS: A total of 60 subjects aged 50-84 years and without scoliosis at baseline were selected and followed for a mean of 12.0 years. De novo scoliosis >or=10 degrees developed in 22 subjects, and logistic regression analysis revealed that the baseline disc index and lateral osteophyte difference values were independent predictors (P < 0.05). CONCLUSIONS: Incidence of de novo scoliosis was predictable by assessing asymmetric disc degeneration in frontal radiograph. More than 20% decrease in unilateral disc height or more than 5 mm longer osteophyte on one side led to increased incidence of de novo scoliosis, which might also influence long-term results of spinal surgery.

Aged↗

PubMed2006

Cementless total hip arthroplasty using the modular S-ROM prosthesis combined with corrective proximal femoral osteotomy.

We present the results of total hip arthroplasty using S-ROM (Depuy, Warsaw, Ind) prosthesis combined with corrective femoral transverse osteotomy for hips with proximal femoral deformity. Fourteen hips were followed up for a mean of 61 months (range, 36-95 months), with a mean age at surgery of 55 years (range, 44-69 years). The average intraoperative blood loss was 638 mL, and the average operative time was 136 minutes. The average Harris Hip Score increased from 38.0 (range, 15.0-55.7) preoperatively to 82.0 (range, 34.6-92.7) at the latest follow-up. All the hips except for 1 acquired union of osteotomy and bone ingrowth. S-ROM modular stem, which gives sufficient rotational stability at both proximal and distal parts of the osteotomy, is useful for total hip arthroplasty combined with corrective femoral transverse osteotomy.

Adult↗

PubMed2006

Fixation with poly-L-lactide screws in hip osteotomies.

UNLABELLED: The purpose of our study was to investigate the bone union rates and complication rates, including breakage of screws, infection, and osteolysis, in hip osteotomies using poly-L-lactic screws. We prospectively followed up 111 hips in 100 patients using conventional radiography, in which 81 rotational acetabular osteotomies, 26 Chiari pelvic osteotomies, and four Sugioka's transtrochanteric osteotomies were performed. The mean age of the patients at the time of surgery was 34 years, and the mean followup was 5.4 years. Eighty-one osteotomized acetabula and 98 osteotomized greater trochanters were fixed using poly-L-lactic screws. These hips were compared with 64 hips in 58 patients using metallic screws. Bone union was achieved in 80 of the 81 acetabular osteotomies, except in one hip with postoperative deep infection. Proximal displacement of the greater trochanter because of poly-L-lactic screw breakage occurred in six (6%) hips. None of the metallic screws broke. Osteolysis occurred in one hip with a trochanteric osteotomy using poly-L-lactic screws. Poly-L-lactic screws are suitable to transfix the osteotomized acetabulum, but there is some risk of fracture when used to reattach an osteotomized greater trochanter. Complete bone ingrowth in the screw channels cannot be expected for several years after insertion. Osteolysis is a possible complication. LEVEL OF EVIDENCE: Therapeutic study, Level II (prospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence.

Absorbable Implants↗

PubMed2006

Relationship between bone marrow edema and development of symptoms in patients with osteonecrosis of the femoral head.

OBJECTIVE: The purpose of this study was to determine the significance of risk factors on MR images for predicting the outcome of patients with osteonecrosis of the femoral head. SUBJECTS AND METHODS: Eighty-three asymptomatic or minimally symptomatic hips in 61 consecutive patients were followed up prospectively. Inclusion criteria included osteonecrosis of the femoral head identified by typical MRI findings, with no radiographic evidence of progression of collapse, and Harris hip score of 85 points or more. Every 3 months, the patients underwent clinical and radiographic examination, and MR images were obtained at 6- to 12-month intervals. Follow-up continued until worsening of hip pain with Harris hip score of less than 70 points or surgery. Asymptomatic hips were followed up for at least 24 months. The mean clinical and radiographic follow-up period after the initial diagnosis was 60 months (range, 3-168 months). RESULTS: Thirty-six (43%) of the 83 hips were symptomatic at the last follow-up. Bone marrow edema was present in 28 hips (34%) during the follow-up period. Twenty-seven (96%) of the 28 hips were symptomatic, and bone marrow edema significantly correlated with worsening of hip pain (p < 0.0001). The necrotic volume of hips with bone marrow edema was significantly larger than those without bone marrow edema (p < 0.0001). Bone marrow edema was found to be the most significant risk factor for worsening of pain (p < 0.0001). CONCLUSION: Bone marrow edema strongly correlated with necrotic volume and was the most significant risk factor for worsening of hip pain. A large necrotic volume of 30% or more may be the second useful indicator for predicting future worsening of hip pain.

Adolescent↗

PubMed2005

Transtrochanteric rotational osteotomy for osteonecrosis of the femoral head: relation between radiographic features and secondary collapse.

BACKGROUND: Secondary collapse of the femoral head after transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head is a major complication leading to failure. We investigated the relation between the extent and shape of a newly established healthy weight-bearing area and the incidence of secondary collapse. METHODS: Altogether, 38 hips in 32 patients with a mean age of 33 years at the time of surgery were followed for a mean of 4 years. RESULTS: The outcome was satisfactory in 22 hips (58%) and unsatisfactory in 16 hips (42%), with 9 requiring total hip arthroplasty. The extent of the newly established healthy weight-bearing area as depicted on the immediate postoperative radiograph was significantly greater in the satisfactory group than in the unsatisfactory group. The rate of secondary collapse was significantly higher when the newly established weight-bearing area was thin, like a beak ("beak-shaped" healthy area). The incidence of a beak-shaped healthy area was significantly higher in the steroid group than in nonsteroid group. CONCLUSIONS: We concluded that we should be cautious when the newly established healthy weight-bearing area exhibits this beak shape, even if its extent in the weight-bearing area is large, because of the higher risk of postoperative secondary collapse. In such cases, alteration of the after-treatment program (e.g., prolonging the non-weight-bearing period) should be considered.

Adolescent↗

PubMed2005

Intertrochanteric varus osteotomy for osteoarthritis in patients with hip dysplasia: 6 to 28 years followup.

UNLABELLED: There have been few reports regarding midterm to long-term results of intertrochanteric varus osteotomy for treatment of hip dysplasia. We investigated 55 hips in 46 patients, with an average age at surgery of 32 years (range, 12-55 years), for an average followup of 17 years (range, 6-28 years). Preoperative osteoarthritis was Tonnis Grade 0 in seven hips, Grade 1 in 23 hips, Grade 2 in 21 hips, and Grade 3 in four hips. Preoperative anteroposterior radiographs of the 55 hips showed almost perfect congruency between the acetabulum and the femoral head with the hip in an abducted position. Excellent or good clinical results were obtained in 23 hips (42%). Using a Harris hip score less than 70 points or the time until additional surgery as the end point, the cumulative rates of survival were 81% at 10 years, 60% at 20 years, and 50% at 25 years. The clinical results of patients with Grade 0, 1, or 2 osteoarthritis, with good spherical femoral head and mild dysplasia, were acceptable; however, this osteotomy might not be indicated for patients with Grade 3 osteoarthritis or for those with severe acetabular dysplasia. LEVEL OF EVIDENCE: Therapeutic study, Level IV (case series--no, or historical control group). See the Guidelines for Authors for a complete description of levels of evidence.

Adolescent↗

PubMed2005

Chiari pelvic osteotomy for advanced osteoarthritis in patients with hip dysplasia.

BACKGROUND: It is not clear whether a Chiari pelvic osteotomy performed for the treatment of advanced osteoarthritis can delay the need for total hip arthroplasty. We present the mid-term results of the Chiari pelvic osteotomy performed for the treatment of Tönnis grade-3 osteoarthritis (large cysts, severe narrowing of the joint space, or severe deformity or necrosis of the head with extensive osteophyte formation), with a particular focus on whether this procedure can delay the need for total hip arthroplasty. METHODS: We followed thirty-two hips in thirty-one patients with Tönnis grade-3 osteoarthritis who had refused total hip arthroplasty and had been treated with a Chiari pelvic osteotomy. The mean age at the time of surgery was 35.2 years. The mean duration of follow-up was 11.2 years, at which time clinical evaluation with the Harris hip score and radiographic evaluation were performed. RESULTS: The average Harris hip score improved from 52 points preoperatively to 77 points at the time of follow-up; the average pain score improved from 20 to 31 points. Three hips with a hip score of <70 points required total hip arthroplasty. With a hip score of <70 points as the end point, the cumulative rate of survival at ten years was 72%. The clinical outcome was significantly influenced by the preoperative center-edge angle (p = 0.004), the preoperative acetabular head index (p = 0.039), achievement of the appropriate osteotomy level (p = 0.011), and superior migration (p = 0.009) and lateral migration (p = 0.026) of the femoral head. CONCLUSIONS: Although the clinical results were inferior to those of total hip arthroplasty, Chiari pelvic osteotomy may be an option for young patients with advanced osteoarthritis who prefer a joint-conserving procedure to total hip arthroplasty and accept a clinical outcome that is predicted to be less optimal than that of total hip arthroplasty. Moderate dysplasia and moderate subluxation without complete obliteration of the joint space and a preoperative center-edge angle of at least 10 degrees are desirable selection criteria.

Hip Dislocation, Congenital↗

PubMed2004

A longitudinal study of congruent sagittal spinal alignment in an adult cohort.

STUDY DESIGN: A 10+-year longitudinal study of 100 adult volunteers. OBJECTIVES: To identify congruent lumbar lordosis in association with other sagittal spinopelvic parameters. SUMMARY OF BACKGROUND DATA: The aging spine poses difficult problems in determining appropriate lumbar lordosis. The concept of congruent spinal alignment is preferred over that of normal spinal alignment, yet the definition of sagittal spinal congruity in elderly population has not been well documented. METHODS: A population-based recruitment of adult volunteers and follow-up of 10+ years was conducted. A total of 100 healthy volunteers with baseline age of 50+ years were subjected to standing entire spine radiographs. Radiologic parameters included lumbar lordosis, sacral inclination, sagittal spinal balance, and other sagittal alignments. RESULTS: Average age of the subjects was 62.0 years at baseline and 73.9 years at follow-up. Lumbar lordosis with <5 degrees change during observation was defined as stable lumbar lordosis (n = 34). Regression analyses of the baseline parameters revealed that sacral inclination was the sole predictor of stable lumbar lordosis (lumbar lordosis = 0.8 * sacral inclination, r = 0.94, P < 0.0001). Baseline lumbopelvic congruity, determined as 0.7 <or= lumbar lordosis/sacral inclination <or= 0.9, was associated with minimum alterations in sagittal spinal alignment, whereas subjects with incongruent lumbopelvic relationships were predisposed to developing kyphosis and spinal imbalance. CONCLUSIONS: Our study substantiates previous results showing that the strongest determinant of lumbar lordosis is sacral alignment. Appropriate lumbar lordosis was estimated to be 80% of sacral inclination using standing radiographs, and the proposed lumbopelvic congruity could measure stability in sagittal spinal alignment. This study provides practical data for the assessment of sagittal spinal alignment in the aging spine.

Adult↗

PubMed2004

Custom-shaping system for bone regeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet.

New bone for the repair or the restoration of the function of traumatized, damaged, or lost bone is a major clinical need, and bone tissue engineering has been heralded as an alternative strategy for regenerating bone. A novel web-like structured biodegradable hybrid sheet has been developed for bone tissue engineering by preparing knitted poly(DL-lactic-co-glycolic acid) sheets (PLGA sheets) with collagen microsponges in their openings. The PLGA skeleton facilitates the formation of the hybrid sheets into desired shapes, and the collagen microsponges in the pores of the PLGA sheet promote cell adhesion and uniform cell distribution throughout the sheet. A large number of osteoblasts established from marrow stroma adhere to the scaffolds and generate the desired-shaped bone in combination with these novel sheets. These results indicate that the web-like structured novel sheet shows promise for use as a tool for custom-shaped bone regeneration in basic research on osteogenesis and for the development of therapeutic applications.

Absorbable Implants↗

PubMed2004

Total hip arthroplasty using an Omniflex modular system: 5 to 12 years followup.

We evaluated intermediate-term results of primary cementless Omniflex prostheses. Forty-nine patients (57 hips) with a mean age of 44 years were observed for an average of 8.6 years. The average Harris hip score was 46 points before surgery and 87 points at final followup. Revision was done in five hips (9%) in five patients. Two acetabular components (4%) were revised because of breakage of the polyethylene insert. Three femoral components (5%) were revised because of aseptic loosening. Six femoral components (10%) were radiographically loose. Overall, 11 hips (19%) were considered mechanical failures. Osteolysis was identified around three acetabular components (5%) and around 20 femoral components (35%). Nine hips (16%) had femoral osteolysis around the distal stem tip. The average annual polyethylene liner wear was 0.18 mm. These results were inferior to those using other recent cementless total hip systems.

Adult↗

PubMed2004

Bone marrow cells carrying the env-pX transgene play a role in the severity but not prolongation of arthritis in human T-cell leukaemia virus type-I transgenic rats: a possible role of articular tissues carrying the transgene in the prolongation of arthritis.

Transgenic rats carrying the env-pX gene of human T-cell leukaemia virus type-I (env-pX rats) were immunized with type II collagen (CII), and chronological alterations of arthritis were compared with findings of collagen-induced arthritis (CIA) in wildtype Wistar-King-Aptekman-Hokudai (WKAH) rats. Arthritis induced by CII in env-pX rats was more severe and persisted longer than CIA in WKAH rats. To determine whether the phenomenon is caused mainly by the transgene-carrying lymphocytes or articular tissues, we immunized lethally irradiated env-pX and WKAH rats with reciprocal bone marrow cell (BMC) transplantation. A severe but transient arthritis was induced by CII in WKAH rats reconstituted by env-pX BMC (w/tB/CII rats). On the other hand, in env-pX rats reconstituted by WKAH BMC, arthritis persisted longer than in w/tB/CII rats, although the degree was less at an early phase after CII immunization. These findings suggest that articular tissues rather than the BMCs carrying the env-pX transgene play a role in the prolongation of arthritis in env-pX rats, although BMCs carrying the transgene are associated with the severity of arthritis. When inflammatory cytokines in synovial cells isolated from env-pX rats before they developed arthritis were examined, interleukin-6 (IL-6) was detected at a higher level than in synovial cells from WKAH rats, thus suggesting the critical role of IL-6 in env-pX arthritis.

Animals↗

PubMed2004

Chiari pelvic osteotomy for advanced osteoarthritis in patients with hip dysplasia.

Adolescent↗

PubMed2003

Periprosthetic acetabular bone loss using a constrained acetabular component.

We describe two patients with a constrained acetabular component who required treatment for recurrent dislocation showing postoperative periprosthetic acetabular bone loss. These hips required revision surgery and demonstrated considerable bone loss caused by the migrated acetabular component. Impingement may have occurred with increased stress at the bone-prosthesis interface, and the sharp ends of screws with a metal shell may have gradually plowed up the acetabular bone. These failures illustrate the potential risk of using a constrained acetabular component.

Acetabulum↗

PubMed2003

Primary clear cell sarcoma (malignant melanoma) in the right radius.

Clear cell sarcoma (malignant melanoma) originating in bone is an extremely rare occurrence, which has been reported twice previously. It is challenging to differentiate this neoplasm from skeletal metastasis of malignant melanoma because it shows no specific imaging, pathological or immunohistochemical features. However, this differentiation is clinically important due to significant differences in patient management. In this article, we present the case of a 55-year-old man with primary clear cell sarcoma arising in the right radius.

Bone Neoplasms↗

PubMed2003

Modulation of hepatic granulomatous responses by transgene expression of DAP12 or TREM-1-Ig molecules.

DAP12 (also known as KARAP) is a novel ITAM-bearing transmembrane adapter molecule that is expressed on the cell surface of natural killer cells, monocytes, dendritic cells, and macrophages. Several myeloid cell-specific DAP12-associating receptors, such as TREM receptor family, SIRP-beta1, and MDL-1 have been identified. The in vivo function of DAP12 and its associating molecules in inflammation has remained primarily unknown. To investigate DAP12 signaling during chronic inflammation, we constructed two adenoviral gene transfer vectors to express FLAG/DAP12 (Ad-FDAP12) and the extracellular domain of mouse TREM-1 and the Fc portion of human IgG1 (Ad-TREM-1 Ig), respectively, and observed their modulatory activities in a mouse model of hepatic granulomatous inflammation elicited by zymosan A. Mice were injected with zymosan A intravenously and 24 hours after zymosan A, they were injected with Ad-FDAP12 or Ad-TREM-1 Ig. Zymosan A-induced hepatic granuloma formation peaked at day 7 and markedly declined by day 10. Although adenoviral-mediated DAP12 gene transfer did not enhance granuloma formation by day 7, it sustained and enhanced granuloma formation beyond day 7. However, an anti-FLAG monoclonal antibody used to potentiate the signaling of adenoviral-derived DAP12, enhanced granuloma formation at day 7. In sharp contrast to the effect by Ad-FDAP12, transgene expression in the liver of soluble form of extracellular domain of TREM-1 as an antagonist of DAP12 signaling, remarkably inhibited zymosan A-induced granuloma formation at all time points examined. Our findings thus suggest that both DAP12 and TREM-1 are involved in the development of granulomatous responses in the liver.

Adaptor Proteins, Signal Transducing↗

PubMed2003

Acetabular components without bulk bone graft in revision surgery: A 5- to 13-year follow-up study.

Eighty-three consecutive revisions in 74 patients using a porous-coated acetabular component without bulk bone graft were followed up for an average of 9.3 years (range, 5-13 years). A large-diameter cup was implanted in hips with adequate osseous support, and a high hip center technique using a standard- or smaller-diameter cup was selected in hips without sufficient bone stock. Acetabular bone deficiency was segmental in 18 hips, cavitary in 30, and combined segmental and cavitary in 35. Four (5%) cups were revised again; 1 for infection, 1 for dislodgement of the polyethylene liner from the metal shell, and 2 for recurrent dislocation. No acetabular components were categorized as definitely loose at final follow-up. The current satisfactory results encourage the use of this simple technique.

Acetabulum↗

PubMed2003

Intermediate-term results after hybrid total hip arthroplasty for the treatment of dysplastic hips.

BACKGROUND: In recent studies, good intermediate-term results have been reported after primary hybrid total hip arthroplasty (a cementless acetabular component with a cemented femoral stem) for the treatment of primary osteoarthritis. However, few studies have described the results of this technique in patients with developmental dysplasia of the hip. METHODS: One hundred primary hybrid total hip replacements were performed in ninety patients to treat degenerative arthritis of the hip secondary to developmental dysplasia. Seventy-one patients (eighty-one hips) were available for clinical and radiographic evaluation. The average duration of follow-up was 10.6 years. There were ten men and sixty-one women. Seventy hips were classified as type 1 (dysplasia); seven, as type 2 (low dislocation); and four, as type 3 (high dislocation), according to the classification system of Hartofilakidis et al. RESULTS: At the time of the final follow-up, the average Harris hip score was 86 points. Structural autograft was used in fifteen hips to supplement acetabular coverage. Within five years postoperatively, the acetabular component in six of the fifteen hips had an average of 4.5 mm of vertical migration and an average increase in vertical rotation of 3 degrees, but the position appeared to stabilize thereafter. Revisions were performed in two hips because of recurrent dislocation. No acetabular or femoral component was revised because of aseptic loosening. Osteolysis was identified around two acetabular components and two femoral components. The average rate of polyethylene wear was 0.09 mm per year. CONCLUSIONS: Hybrid total hip arthroplasty for the treatment of symptomatic degenerative arthritis secondary to developmental dysplasia provides favorable results at intermediate-term follow-up. With lower grades of dysplasia, the majority of patients can be treated effectively without a structural bone graft by placement of the cementless acetabular component at a medial or high position.

Adult↗