Biomedical subjects

Tami Irwin Sherman

Publications and source records attributed to Tami Irwin Sherman.

4 recordsLinked to original sources

PubMed2006

Estradiol levels and secretory dynamics in normal girls and boys as determined by an ultrasensitive bioassay: a 10 year experience.

We utilized an ultrasensitive recombinant cell bioassay to measure serum estradiol in 800 normal children from birth through puberty. 105 children had repeat samples every 4 months as they approached puberty. We measured estradiol levels every hour for 24 hours in 55 children. Estradiol increased with age and pubertal stage in girls and boys, and was higher in girls than boys at each stage. Prepubertal girls have estradiol levels of 1.6 +/- 2.6 pg/ml. Prepubertal boys have estradiol levels of 0.4 + 1.1 pg/ml. Estradiol had a diurnal variation in girls and boys, with the trough occurring 08.00-20.00 h in girls, and 12.00-20.00 h in boys. We confirm that estradiol levels are higher in girls than boys even before physical signs of puberty, and that estradiol increases throughout puberty in girls and boys. This 10-year experience in 800 children shows the range and variability of estradiol by an ultrasensitive bioassay.

Adolescent↗

PubMed2002

Leptin and estradiol as related to change in pubertal status and body weight.

BACKGROUND: Previous studies have examined the relationship between leptin, body mass, and pubertal status. The present study directly compares the relationship of leptin and estradiol in 5 groups of girls with different combinations of pubertal status and weight. MATERIAL/METHODS: We studied girls with idiopathic precocious puberty, age-matched non-obese prepubertal girls, age-matched obese prepubertal girls, normal pubertal girls, and obese pubertal girls (n=12/group). RESULTS: Leptin levels were significantly higher in obese pubertal girls (26.6+/-8.4 ng/mL) than in all others. Leptin levels were significantly higher in obese prepubertal girls (20.7+/-10.9 ng/mL) (mean+/-SD) compared to girls with precocious puberty (7.7+/-5.4 ng/mL, p<0.004), non-obese prepubertal girls (5.55+/-3.6 ng/mL, p<0.001), and normal pubertal girls (4.8+/-2.9 ng/mL, p<0.001). Leptin level did not correlate significantly with estradiol level. Leptin-SDS (standard deviation score), which corrects leptin level for gender, pubertal stage, and BMI, was significantly lower in the obese pubertal group than in the 3 non-obese groups. CONCLUSIONS: These findings confirm previous studies that body mass, chronological age and pubertal stage are determinants of leptin level. However, these are not the only factors determining leptin level as evidenced by persistent differences in leptin level between obese and non-obese pubertal girls even when correcting for pubertal stage and BMI. While the present study provides no new answers to the question of pubertal regulation, it provides a direct comparison of combinations of weight, pubertal stage, and leptin level, as background for future studies.

Body Mass Index↗

PubMedDate not supplied

Physiologic effects of CPAP: application and monitoring.

Although a wide array of respiratory care modalities has been employed to manage neonatal respiratory distress syndrome (RDS), the recent focus has emphasized strategies that correct lung pathophysiology while protecting the lung from further insult. Continuous positive airway pressure (CPAP) has remained a viable option for NICU infants since its introduction in 1971. Current methods of monitoring allow clinicians to troubleshoot and better understand the physiologic and clinical impact of administering CPAP to neonates with RDS. This article highlights the renewed interest in CPAP therapy and current methods of monitoring.

Continuous Positive Airway Pressure↗

PubMedDate not supplied

Optimizing the neonatal thermal environment.

Devices used to maintain thermal stability in preterm infants have advanced over time from the first incubator reported by Jean-Louis-Paul Denuce in 1857 to the latest Versalet Incuwarmer and Giraffe Omnibed devices today. Optimizing the thermal environment has proven significant for improving the chances of survival for small infants. Understanding the basic physiologic principles and current methodology of thermoregulation is important in the clinical care of these tiny infants. This article highlights principles of thermoregulation and the technologic advances that provide thermal support to our vulnerable

Air Movements↗