Tanju Gökçeer | PubMed Health

PubMed2006

[The correlation of vascular endothelial growth factor with angiogenesis and p53 gene in laryngeal squamous cell carcinoma].

OBJECTIVES: Angiogenesis is a fundamental process in tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and it has been identified in a wide variety of malignancies, including head and neck squamous cell carcinoma. However, the regulation of VEGF expression in tumor angiogenesis is not well defined. The tumor-suppressor gene p53 is thought to regulate VEGF. In this study, we examined the role of p53 gene in VEGF expression. PATIENTS AND METHODS: Clinical records of patients who underwent total or partial laryngectomy between 1999 and 2002 were reviewed. Of these, paraffin-embedded specimens of 27 patients (27 males; mean age 55 years; range 39 to 74 years) with a diagnosis of larynx epidermoid carcinoma were immunostained to evaluate VEGF expression, p53 gene status, and microvessel density (MVD). Variables were statistically examined. RESULTS: Vascular endothelial growth factor positive staining was detected in 11 (40.7%) and p53 mutations were identified in 16 (60%) tumors. No association was detected between p53 mutations and VEGF expression (p>0.05). Statistical analysis gave a clear correlation between tumor vascularity and VEGF expression (p<0.05). Vascular endothelial growth factor negative tumors showed a lower mean number of microvessels per microscopic field (29.6+/-6.6) than VEGF positive tumors (40.8+/-15.2). P53 and VEGF expression, and MVD were not correlated with the T-stage, N-status, tumor localization, and histological grading (p>0.05). CONCLUSION: The higher microvessel density in VEGF positive tumors supports the importance of VEGF for tumor angiogenesis in laryngeal carcinoma. However, our results do not support the hypothesis concerning a p53 regulation in the angiogenic process through a VEGF up-regulation.

Adult↗

PubMed2004

[Nasal schwannoma: a report of two cases].

Schwannomas are benign neoplasms arising from Schwann cells of peripheral, cranial and autonomic nerves. Schwannomas of the head and neck comprise 25% to 45% of all schwannomas; however, nasal and paranasal schwannomas account for 4% of these tumors. In this report, two cases of nasal schwannoma are presented. One was a 67-year-old female patient whose tumor completely filled the right nasal cavity and extended beyond the maxillary and ethmoid sinuses. The other patient was a 10-year-old child who had a tumor in the left lateral nasal wall, which is a rare case considering her age. A lateral rhinotomy approach was used in the first patient due to the wide extension of the tumor. In the second case we preferred the intranasal approach because the tumor had limited extension. No recurrences were seen in the postoperative follow-up periods.

Aged↗

PubMed2003

[Ethmoid sinus osteoma with orbital extension].

Osteoma is the most common neoplasm of the paranasal sinuses. A fifty-year-old woman who had presented with complaints of protrusion of the eyeball and double vision was referred to our department with a diagnosis of proptosis. Computed tomography of the paranasal sinuses and the orbits showed a high-density mass of 2x3 cm, involving the left ethmoidal cells laterally, the left maxillary sinus superomedially, the left orbit inferomedially, and the nasal cavity superiorly. The mass was removed through the external ethmoidectomy approach. Postoperatively, all visual functions improved. The pathologic diagnosis was osteoma.

Diagnosis, Differential↗