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Tao Zhou

Publications and source records attributed to Tao Zhou.

62 records · Page 4Linked to original sources
PubMed2003

Study of local three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for patients with stage III hepatocellular carcinoma.

The purpose of this study was to evaluate treatment-related toxicity, outcome, patterns of failure, and prognostic factors for patients with stage III unresectable hepatocellular carcinoma (HCC) treated with a combination of local 3-dimensional conformal radiotherapy (3D-CRT) and transcatheter arterial chemoembolization (TACE) under the support of G-CSF. From October 1997 to August 2001, 45 patients with stage III unresectable hepatocellular carcinoma underwent transcatheter arterial chemoembolization with local 3D-CRT. Twenty-seven patients were classified as having stage IIIA disease according to the American Joint Committee on Cancer (AJCC) staging system and 18 were classified as stage IIIB. The mean diameter of the treated hepatic tumor was 8.5 cm. Before 3D-CRT, 2 cycles of transcatheter arterial chemoembolization were prescribed. Forty-eight hours later, the G-CSF was prescribed for 5 days after the completion of every TACE. With the interval of 10 to 14 days after the second cycle of TACE, 3D-CRT was prescribed to all patients with a total dose of 50.4 Gy at 1.8 Gy per fraction 5 days per week. After the completion of 3D-CRT, the additional 2 cycles of TACE were given. All patients were monitored for treatment-related toxicity, outcome, patterns of failure, causes of death, and prognostic factors. Forty-two of 45 patients were treated smoothly with the primary schedule. In a median follow-up period of 27 months, 22 patients were alive and 23 were dead. Progressive disease occurred in 28 patients, including local recurrence alone (4 patients), distant metastases with local recurrence (8 patients), and distant metastases alone (16 patients). Nine patients developed radiation-induced liver disease (RILD). Three patients had treatment-related gastrointestinal bleeding. There were 2 treatment-related deaths, including 1 from RILD and 1 from gastrointestinal bleeding. Complete regression (CR) was observed in 6 patients, partial regression (PR) in 35 patients, and stable disease (SD) in 4 patients. The median overall survival duration from treatment was 23.5 months with a 1-year overall survival rate of 68.5%, a 2-year survival rate of 48.3%, and a 3-year survival rate of 22.6%. The median freedom from progressive disease survival duration from treatment was 25 months with 1-year, 2-year, and 3-year progression-free survival rates of 76.2%, 56.8%, and 42.4%, respectively. The stage of HCC, regional lymph node status, portal vein thrombosis, pretreatment alpha-fetoprotein level (AFP), and tumor size affected the treatment outcomes significantly. Therefore, for patients with stage III unresectable hepatocellular carcinoma, combined local 3D conformal radiotherapy with transcatheter arterial chemoembolization under the support of G-CSF is an effective treatment protocol. Further research is required to decrease distant metastases and to determine the safe irradiation dose-volume.

Adult↗
PubMed2003

[Postoperative rupture of carotid artery in head and neck neoplasms].

OBJECTIVE: To explore the treatment of neoplasms in head and neck invaded the carotid artery. METHODS: Four cases with postoperative rupture of carotid artery invaded by the head and neck cancer were reviewed. The tumours were taken off from the carotid arteries and the carotid artery remained. RESULT: Rupture of carotid artery occurred in 4 patients within one week after radical neck dissection. One patient died because of its rupture again after repair. The other three survived after ligating the artery. CONCLUSION: The carotid artery involved by tumour of head and neck should be prepared for resection before operation. If the artery was obviously invaded by the tumour, both the tumour and artery should be resected together. Once the rupture of the artery occurred after operation, the artery must be ligated instead of being repaired.

Carotid Artery Diseases↗
PubMed2003

[Degradation kinetics for Fhhh strain in PTA wastewater].

Degradation kinetics of the purified terephthalic acid (PTA) petrochemical wastewater with the functional strain Fhhh was conducted in this research. Inputting the values of the 6 kinetics parameters obtained from the test, the values of the natural parameter and the values of the standard parameters for discharging wastewater into the environmental biotechnological informatics software (Ebis), the minimum reactor volume (Vmin) required and the specific degradation rate (qA) were calculated based on the activated sludge process. The minimum value of Vmin was 1309 m3 as well as the highest value of qA was 0.0136 h-1 among the Fhhh preparations kept in three different methods. The highest value of Fhhh qA was 4 fold of that of the native bacterium YZ1, and higher than that of the data published by 4 researchers and lower than that of by 2 researchers. The results show that Fhhh has the obvious potential for the degradation of PTA wastewater.

Biodegradation, Environmental↗
PubMed2002

[Clinical analysis of 17 cases of lung carcinoid tumor].

OBJECTIVE: To study the classification and treatment modalities of lung carcinoid tumor. METHODS: 17 cases of lung carcinoid tumor from May 1983 to May 1998 were reviewed and analysed. RESULTS: Lung carcinoid tumors were classified into two sub-groups: typical carcinoid tumor and non-typical carcinoid tumor. The prognosis of typical carcinoid tumor was better than that of non-typical carcinoid tumor. 3-year survival was 5/6 for typical carcinoid tumor, 4/11 for non-typical carcinoid tumor. There was no statistic significance in the treatment outcome between patients receiving operation + chemotherapy + radiotherapy and patients receiving chemotherapy + radiotherapy in non-typical carcinoid tumor. CONCLUSION: Operation should be considered as the first choice for typical carcinoid tumor that has a good prognosis. Non-typical carcinoid tumor tends to be metastatic and has a poor prognosis. Chemotherapy should be considered as the first choice and radiotherapy as palliative for non-typical carcinoid tumor.

Adult↗
PubMed2000

[Study on Methylation of p15(INK4B) Gene in Acute Myeloid Leukemia and Chronic Myeloid Leukemia]

In order to explore the role of p15(INK4B) gene with highly methylated CpG island in the pathogenesis of leukemia, the expression levels of p15(INK4B) gene was detected in patients with AML and CML. Methylation-specific PCR (MSP) assay was employed in the experiments. The methylation incidence was 83.9% (26/31) in AML and 0% (0/28) in CML. The results showed that methylation of p15(INK4B) gene was the one of the major ways for inactivation of the gene, and the methylation could be appeared in clinical development of the disease and patients condition worsened. Methylation of p15(INK4B) did not occur and its function probably is normal in CML.

Journal Article↗
PubMed2000

[Detection of High Methylation of p15(INK4B) and p16(INK4A) Genes in Multiple Myeloma]

To study the action, characteristics and expression of high methylation of p15(INK4B) and p16(INK4A) genes in multiple myeloma (MM), the sensitive methylation specific PCR method was employed to detect the hypermethylation of p15(INK4B) and p16(INK4A) in 24 patients with MM. Results showed that the methylation incidence of p15(INK4B) and p16(INK4A) genes were 70.8% (17/24) and 58.3% (14/24) in the MM patients, with the products of 148 bp and 150 bp fragments, respectively. The methylation of p15(INK4B) and p16(INK4A) genes were simultaneously happened in MM patients of plasmocytoma type with two cases at II phase and two cases at III phase. The simultaneous non-methylation of p15(INK4B) and p16(INK4A) genes were founded in five cases of MM patients, all of the tumor cells were of small plasmocyte type with mature differention. Conclusion suggested that there were high incidence of methylation of p15(INK4B) and p16(INK4A) genes in patients with MM. Hypermethylation can be detected in the early stage of disease, which was associated with its progress. It indicated a bad prognosis when methylation happended simultaneously in the two genes. Methylation of p15(INK4B) and p16(INK4A) genes may be related to the pathogeny of MM.

Journal Article↗
PubMedDate not supplied

Analysis of stimulated Brillouin scattering in multi-mode fiber by numerical solution.

Stimulated Brillouin scattering in optical fibers is described by a theoretical model and numerical analysis. The results showed that, for an optical fiber pumped by a laser beam with ns-order-pulse width and kW-order peak-power, SBS reflectivity tends to saturate when the fiber length exceeds a limit, named "effective fiber length". Using small core-diameter and long enough fiber, the SBS reflectivity level could be raised but is limited by optical damage of the entrance surface of the fiber. Therefore, just a small dynamic range can be obtained.

Computer Simulation↗