Biomedical subjects

Terri S Armstrong

Publications and source records attributed to Terri S Armstrong.

4 recordsLinked to original sources

PubMed2004

The treatment of neoplastic meningitis.

Neoplastic meningitis (NM) is a debilitating complication of cancer that occurs when tumour cells infiltrate the leptomeninges. Treatment often includes direct installation of chemotherapy into the cerebrospinal fluid either by lumbar puncture or the use of a ventricular reservoir, radiation therapy, systemic chemotherapy or a combination of these modalities. The current standard chemotherapeutic agents for direct instillation into the cerebrospinal fluid include methotrexate, cytarabine and thiotepa. Other agents, such as topotecan, manfosfamide and IFNs, are undergoing evaluation in clinical trials. Despite active investigation of new therapies, the prognosis for patients with NM remains poor. However, some patients do demonstrate improvement of neurological function and prolongation of survival with treatment. Therefore, careful evaluation and treatment planning is warranted in order to avoid treatment-associated toxicities and to maximise the impact of the treatment on the disease process.

Antineoplastic Agents↗

PubMed2002

Glial tumors--new approaches in chemotherapy.

While malignant glioma remains a devastating diagnosis, recent significant advances are occurring, which we hope will have a positive effect on patient survival. Agents designed to target specific processes and structures involved in tumor cell division and innovative combinations of cytotoxic and cytostatic therapies offer future hope for the efficacious treatment of gliomas.

Antineoplastic Agents↗

PubMedDate not supplied

Seize the moment to learn about epilepsy in people with cancer.

Seizures are common neurologic complications of cancer and can occur at any point in the disease trajectory. Despite this, the exact pathophysiologic basis of seizures related to cancer is not known. The etiology of seizures is thought to be multifactorial, including the presence of tumors within the cranial cavity, metabolic derangements, and the direct effect of medications on the central nervous system. Seizure management often employs anticonvulsant medications and interventions to promote patient safety. Oncology nurses must be aware of the potential seriousness of this complication and implement appropriate strategies to assist patients in maintaining safety and quality of life.

Anticonvulsants↗

PubMedDate not supplied

Symptoms experience: a concept analysis.

PURPOSE/OBJECTIVES: To provide a clearly constructed definition of the concept of symptoms experience. DATA SOURCES: Articles and book chapters. DATA SYNTHESIS: Symptoms experience has not been explored previously. Several approaches to the concept of symptoms have been addressed, including symptom occurrence, symptom distress, and unpleasant symptoms. Limitations of these approaches may include the lack of focus on symptoms as occurring concurrently or in clusters or the multiplicative nature of symptoms. In addition, situational and existential meaning often is not explored. CONCLUSIONS: Symptoms experience is the perception of the frequency, intensity, distress, and meaning of symptoms as they are produced and expressed. Symptoms are multiplicative in nature and may act as catalysts for the occurrence of other symptoms. Antecedents to the symptoms experience include demographic, disease, and individual factors. Consequences include the impact on mood state, psychological status, functional status, quality of life, disease progression, and survival. IMPLICATIONS FOR NURSING: Evaluation of symptoms in patients with cancer should include a meaning-centered approach, in which symptoms are evaluated not only for occurrence characteristics and perceived distress but also for the meaning of the symptoms experience to individuals.

Adult↗