Biomedical subjects

Terry A Clyburn

Publications and source records attributed to Terry A Clyburn.

3 recordsLinked to original sources

PubMed2004

Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model.

Biodegradable microspheres were manufactured from a high molecular weight copolymer of 50% lactic and 50% glycolic acid and the antibiotic tobramycin. It was hypothesized that the microspheres would be more effective than polymethylmethacrylate beads in the local delivery of tobramycin and that the microspheres would not inhibit bone healing. Osteomyelitis was established in 40 New Zealand White rabbits using Staphylococcus aureus. All animals had irrigation and debridement of the infected radii four weeks after inoculation and were divided into five treatment groups: debridement alone, microspheres alone, microspheres containing tobramycin plus parenteral treatment with cefazolin, polymethylmethacrylate beads containing tobramycin plus parenteral cefazolin, and parenteral cefazolin. All animals were sacrificed after 4 weeks of treatment. The group treated with microspheres plus parenteral antibiotics was the only group to have a significantly higher percentage of animals without bacteria after 4 weeks of treatment when compared with the control group. Additionally, the animals treated with microspheres had a higher degree of bone healing in the defect than the animals treated with bone cement. The most effective treatment was biodegradable microspheres combined with parenteral antibiotic in this rabbit osteomyelitis model.

Animals↗

PubMed2003

Constrained acetabular cups: a cadaveric biomechanical evaluation.

Reports indicate that constrained acetabular cups may reduce range of motion and catastrophically fail, although the biomechanics of dislocation have not been reported. We measured the available motion in 6 constrained cups (from 2 manufacturers) when anatomically placed in cadaver pelves. We measured the torque and rotation necessary to dislocate the hip. Range of motion was measured using a custom jig and revealed a functional range of motion with all cup positions. Extension was limited to 0 degrees with anteversion of 11 degrees to 29 degrees. Thus, anteversion of <10 degrees is recommended. Torque and rotation to produce dislocation was 7 ft-pounds and 11 ft-pounds and 82 degrees and 72 degrees, for each manufacturer. Torques were reduced with subsequent dislocations. We recommend consideration of polyethylene replacement if dislocation occurs. Dislocation occurred at the ball-polyethylene interface without catastrophic failure.

Acetabulum↗

PubMed2003

Antibiotic microspheres: preliminary testing for potential treatment of osteomyelitis.

Osteomyelitis is a difficult problem for orthopaedic surgeons. The current standard of treatment requires high doses of antibiotic to be administered parenterally, which can damage vital organs. A local drug delivery system, which targets only the infected tissues, would eliminate some of the complications associated with extended courses of parenteral antibiotic treatment. In the current study, biodegradable microspheres were manufactured from a high molecular weight copolymer of 50% lactic and 50% glycolic acid and the antibiotic tobramycin. Various formulations of microspheres were tested for in vitro elution characteristics to determine the optimum formulation for linear release of antibiotic for at least 4 weeks. The optimal formulation then was implanted into a pouch created in the quadriceps muscle of mice to evaluate the in vivo elution of the antibiotic and the inflammatory response elicited by the microspheres. Results indicate that a sustained linear release of antibiotic from the microspheres is possible for a period of at least 4 weeks and that the inflammatory response was within levels required for the microspheres to be considered biocompatible.

Animals↗