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Biomedical subjects

Terry Allen

Publications and source records attributed to Terry Allen.

4 recordsLinked to original sources

Improving housing, improving health: the need for collaborative working.

The impact of poor housing on health was recognized 150 years ago, and doing something about it was the first real public health initiative. Today, standards in much of the older housing stock continue to fall and, exacerbated by the current free market boom in fuel costs, many people cannot afford to heat or maintain their homes. In response to this crisis, there is an increasing amount of housing help available which would directly improve the health of patients but, apart from pockets of exemplary practice, most health practitioners seem to do little about it. Yet housing issues feature prominently in nurse training, as well as receiving increasing emphasis through the current national and regional fuel poverty initiatives. In exploring this paradox the author examines the mixed fortunes of an innovative project which tried to stimulate collaborative working between professions by providing a successful combined health and housing intervention. Drawing on his evaluation of this project over five years, he considers what some of the barriers to collaboration might be, how they arise and what needs to be done to overcome them.

Chronic Disease↗

Preventing falls in older people: evaluating a peer education approach.

Initiatives in falls prevention usually rely on the expertise of health professionals and are therefore limited in scope. In order to reach a wider audience, a peer education programme in Bradford gave one-off sessions to groups of older people providing information about falls prevention and demonstrating simple balance and strength building exercises. Although evaluation found the programme to be well received, it also revealed a high rate of undisclosed falls and a reluctance to inform, or seek advice from, health professionals. It was not clear how far this was to do with embarrassment or being seen as not coping, but suggests that a more appropriate role for health professionals may be one that is complementary and supportive within a broad educational and facilitative programme embodying peer education.

Accident Prevention↗

The conserved Nup107-160 complex is critical for nuclear pore complex assembly.

Nuclear pore complexes (NPCs) are large multiprotein assemblies that allow traffic between the cytoplasm and the nucleus. During mitosis in higher eukaryotes, the Nuclear Envelope (NE) breaks down and NPCs disassemble. How NPCs reassemble and incorporate into the NE upon mitotic exit is poorly understood. We demonstrate a function for the conserved Nup107-160 complex in this process. Partial in vivo depletion of Nup133 or Nup107 via RNAi in HeLa cells resulted in reduced levels of multiple nucleoporins and decreased NPC density in the NE. Immunodepletion of the entire Nup107-160 complex from in vitro nuclear assembly reactions produced nuclei with a continuous NE but no NPCs. This phenotype was reversible only if Nup107-160 complex was readded before closed NE formation. Depletion also prevented association of FG-repeat nucleoporins with chromatin. We propose a stepwise model in which postmitotic NPC assembly initiates on chromatin via early recruitment of the Nup107-160 complex.

Animals↗