Intraocular biopsy.
This article discusses the indications for intraocular tumor biopsy, the techniques used for obtaining material, and the approaches for analysis of these specimens.
Biopsy, Fine-Needle↗
Biomedical subjects
Theodore Miller
Publications and source records attributed to Theodore Miller.
Analysis of melanoma cell type in uveal melanoma following treatment failure.
PURPOSE: To determine whether an increase (or progression) in the degree of malignancy according to cytologic or histopathologic criteria corresponded with failure of intraocular melanoma control. DESIGN: Retrospective case control study from a single institution. METHODS: Uveal melanoma patients had either fine-needle aspiration biopsy followed by irradiation and later enucleation or an eyewall resection followed by enucleation. The observation procedures were serial histology or cytopathology and histology, reanalyzed in a masked manner. The main outcome measures were change in the predominant tumor cell type, local tumor control, and metastases. RESULTS: There was not a significant correlation between a change in melanoma cell type and failure to control intraocular melanoma. Similarly, the latency between treatment and enucleation was actually less (but not statistically so) in tumors that showed no increase in melanoma malignancy cell type compared with those that had a more malignant cell type on serial examination. CONCLUSIONS: There was no correlation between a change to more a malignant cell type and local control failure in patients treated either with radiation or eyewall resection for uveal melanoma.
Biopsy, Needle↗
Orbital fibrous histiocytomas.
Orbital fibrous histiocytomas can be difficult to diagnose and manage. These tumors, especially those with intermediate histologic features, often recur. Historically, non-invasive tests to differentiate scars from recurrent disease have a high error rate. We present a case of recurrent orbital fibrous histiocytoma in which the diagnosis was established with poitron emission tomography (PET) scans. This technique may be helpful in difficult cases to differentiate scars from a recurrent mesenchymal tumor.
Journal Article↗