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Biomedical subjects

Thomas Ashley

Publications and source records attributed to Thomas Ashley.

4 recordsLinked to original sources

Mortality and Morbidity Liaison Committee--ISCS body mass index study.

OBJECTIVE: This study used the Impairment Study Capture System (ISCS) to examine the relationship between mortality and body mass index (BMI) in an insured population, particularly BMI in isolation from other risk factors. BACKGROUND: Large-scale studies of build in an insured population have traditionally been done on policies issued at standard premium rates. Insured mortality experience on elevated BMI is scarce or outdated. Increasingly competitive underwriting of build throughout the years has influenced what has been issued standard, and therefore, the relative experience of substandard to standard business. METHODS: We studied 241,966 policies submitted through the ISCS between 1989 and 2003 with actual height and weight and a code signifying abnormal build. Actual BMI were derived for these insureds. The average BMI was 35.0. Standardized mortality ratios (SMR) were computed using the 2001 Valuation Basic Table (VBT) as the expected basis. The average duration of exposure was 2.5 years. Results were stratified by underwriting factors of interest. RESULTS: Standardized mortality ratios rose quite modestly as BMI increased up until reaching severe obesity. Ratios for nonsmoker policies where elevated build was the only impairment saw SMR of 265% at BMI < 18.5, 130% at BMI 30.0-34.9, 160% at BMI 35.0-39.9 and 239% at BMI > or = 40.0. Ratios where other impairments were present tended to be higher in moderately obese ranges and lower at extremely obese ranges. No underwriting factor of significance impacted the pattern of ratios as BMI increased. CONCLUSIONS: While an average of 3 years may not be long enough to see the true manifestations of obesity, excess mortality is exhibited at low and high BMI ranges, especially when seen in isolation. The study is not a direct comparison of obese to non-obese subjects, but it is a point of reference for how obese insureds have fared vs standard issued policies. The relatively favorable experience may have more to do with the construction of the (standard) VBT table than any mitigating effect of modest obesity.

Adult↗

Using predictive value, sensitivity and specificity to interpret laboratory tests: PSA for the diagnosis of prostate cancer.

The Prostate Cancer Prevention Trial yields a means to evaluate PSA screening for prostate cancer detection. The receiver operating characteristic curve shows that PSA above 2.5 provides optimum sensitivity and specificity for prostate cancer diagnosis by needle biopsy. However, the maximum positive predictive value of 48% occurs at PSA above 4.0 and does not increase at higher PSA cutpoints. Consideration of test sensitivity and specificity alone is not sufficient for optimal interpretation of test results.

Humans↗

Recurrent PSA after prostatectomy for prostate cancer: implications of PSA doubling time.

After radical prostatectomy for prostate cancer, men frequently develop detectable levels of prostate specific antigen (PSA). A slow rate of increase, as characterized by the PSA doubling time (PSADT) is the principal marker for a favorable prognosis. Data and results presented in 2 recent clinical articles studying cohorts of men with clinical stage T1/T2 prostate cancer are reviewed and used to develop mortality analyses. Life-table analysis shows a mortality ratio of 257% at 5 years for Gleason score < 8, PSA recurrence > 2 years after surgery for clinical stage T1/T2 disease, and PSA doubling time (PSADT) > 10 months. Markov modeling using transition probabilities derived from the clinical articles to develop a life table analysis yields a mortality ratio of 145% at 10 years for similar patients.

Adult↗

Coronary angiography report.

Reports of coronary angiography frequently determine underwriting decisions. This report exemplifies the ideal format and content for effective clinical or insurance risk assessment.

Angioplasty↗