Biomedical subjects

Thomas Carroll

Publications and source records attributed to Thomas Carroll.

4 recordsLinked to original sources

PubMed2006

Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma.

The molecular basis for alternative lengthening of telomeres (ALT), a prognostic marker for glioma patients, remains unknown. We examined TP53 status in relation to telomere maintenance mechanism (TMM) in 108 patients with glioblastoma multiforme and two patients with anaplastic astrocytoma from New Zealand and United Kingdom. Tumor samples were analyzed with respect to telomerase activity, telomere length, and ALT-associated promyelocytic leukemia nuclear bodies to determine their TMM. TP53 mutation was analyzed by direct sequencing of coding exons 2 to 11. We found an association between TP53 mutation and ALT mechanism and between wild-type TP53 and telomerase and absence of a known TMM (P < 0.0001). We suggest that TP53 deficiency plays a permissive role in the activation of ALT.

Adolescent↗

PubMed2006

Objective measurement of vocal fatigue in classical singers: a vocal dosimetry pilot study.

OBJECTIVES: To collect objective vibration dose data on singers and relate them to subjective measurements of vocal fatigue. STUDY DESIGN AND SETTING: Seven subjects completed a 2-week study period. The National Center for Voice and Speech (NCVS) dosimeter recorded vocal load, soft phonation tasks, and subjective soft voice ratings. Three vocal doses (time, distance, and cycle) were measured in classical singers' larynges during an intensive practice period. RESULTS: Spikes in vocal load are reflected as harsher subjective ratings on the same day as well as 24-72 hours later. When at least 48 hours of vocal rest occurred before a vocal load, improved subjective evaluations were seen after the load. CONCLUSIONS: The NCVS dosimeter appears to be an effective tool for data collection on prolonged use of the voice. SIGNIFICANCE: This is the first multi-day study comparing objective and subjective data on vocal fatigue in a group of professional singers.

Adult↗

PubMed2005

Alternative surgical dissection techniques.

The bipolar scissors, coblator, harmonic scalpel, and somnoplasty techniques are widely available and offer new choices for the operating arena. There are advantages and disadvantages to all four techniques. With time, these dissection methods will prove their lasting power. Otolaryngologists have already begun to expand their applications and will surely play a role in their use and development.

Adult↗

PubMed2003

Assessment of damage in an eight-oscillator circuit using dynamical forcing.

We employ chaotic interrogation of a circuit simulation of a structure in order to test for damage to the structure. The circuit simulation provides a realistic test of our attractor-based method and permits close control over parameters in the structure. In this circuit, simulating an eight-degree-of-freedom spring-mass system, we were able to detect changes of as little as 2% in the coupling between two oscillators in the circuit. This corresponded to detection of a 2% loss in stiffness to one spring in the modeled system.

Journal Article↗