Biomedical subjects

Thomas E Nevins

Publications and source records attributed to Thomas E Nevins.

4 recordsLinked to original sources

PubMed2006

Hematuria in children due to schistosomiasis in a nonendemic setting.

Infection with Schistosoma hematobium is common in immigrants from tropical Africa and commonly presents with painless hematuria. Since chronic, heavy infection can lead to significant morbidity, it is imperative for clinicians who serve the immigrant and refugee population to become familiar with this traditionally exotic disease. Increased awareness will allow earlier diagnosis and treatment of infection, avoiding complications and minimizing expensive and invasive diagnostic procedures.

Adolescent↗

PubMed2005

"Why do they do that?" The compliance conundrum.

The problem of compliance or adherence with medical advice is complex in every aspect. Frequently compliance definitions vary, measurements are not well quantified, interventions are uncontrolled or not fully elaborated. Nevertheless the importance of facilitating and maximizing compliance is undeniable. As the medications available become more potent and effective, the challenge of achieving optimal medication compliance comes into sharper focus and becomes a concern for everyone involved in health care. Here some of the recent clinical research on compliance is presented together with strategies intended to improve medication compliance by pediatric patients.

Child↗

PubMed2004

Medication noncompliance: another iceberg's tip.

After renal transplantation, immunosuppressive medications must be taken long-term to avoid acute rejection and the cascade of events leading to "chronic allograft dysfunction" and loss. In the past, when posttransplant immunosuppression was limited to azathioprine and prednisone, acute rejection episodes were common, and it was difficult to identify the impact of medication noncompliance. However, with more potent and effective drugs, acute rejection is uncommon, and medication noncompliance emerges as an increasingly important factor in the outcome of solid-organ transplantation. Recent studies have clearly demonstrated that medication noncompliance leads to an increased incidence of acute rejection, chronic rejection, and graft loss. Today, although a number of questions remain unanswered, new methodologies, such as electronic monitors, provide opportunities to study medication noncompliance and its risk factors, and the potential for earlier intervention to improve clinical outcomes.

Graft Rejection↗

PubMed2002

Non-compliance and its management in teenagers.

Renal transplantation restores a patient's endogenous renal function. The benefits of this restoration are especially dramatic in children. However, transplantation is a complex and expensive therapy which, when successful, requires consistent adherence to a complex regimen of drug therapy and clinical follow-up. Transplant medications need to be taken for a lifetime. Whilst very effective, immunosuppressant medications can also cause a number of side-effects and require daily multi-dose schedules. Teenagers, in particular, have problems adhering to these regimens and weighing the consequences of non-compliance. Approaches to improving teenagers' compliance must address both the special circumstances of adolescence and the broad, general problem of post-transplant non-compliance.

Adolescent↗