Biomedical subjects

Thomas Franosch

Publications and source records attributed to Thomas Franosch.

5 recordsLinked to original sources

PubMed2006

Driven lattice gas of dimers coupled to a bulk reservoir.

We investigate the nonequilibrium steady state of a one-dimensional (1D) lattice gas of dimers. The dynamics is described by a totally asymmetric exclusion process (TASEP) supplemented by attachment and detachment processes, mimicking chemical equilibrium of the 1D driven transport with the bulk reservoir. The steady-state phase diagram and current and density profiles are calculated using both a refined mean-field theory and extensive stochastic simulations. As a consequence of the on-off kinetics, a phase coexistence region arises intervening between low and high density phases such that the discontinuous transition line of the TASEP splits into two continuous ones. The results of the mean-field theory and simulations are found to coincide. We show that the physical picture obtained in the corresponding lattice gas model with monomers is robust, in the sense that the phase diagram changes quantitatively, but the topology remains unaltered. The mechanism for phase separation is identified as generic for a wide class of driven 1D lattice gases.

Computer Simulation↗

PubMed2006

Exclusion processes with internal states.

We introduce driven exclusion processes with internal states that serve as generic transport models in various contexts, ranging from molecular or vehicular traffic on parallel lanes to spintronics. The ensuing nonequilibrium steady states are controllable by boundary as well as bulk rates. A striking polarization phenomenon accompanied by domain wall motion and delocalization is discovered within a mesoscopic scaling. We quantify this observation within an analytic description providing exact phase diagrams. Our results are confirmed by stochastic simulations.

Journal Article↗

PubMed2006

Localization transition of the three-dimensional lorentz model and continuum percolation.

The localization transition and the critical properties of the Lorentz model in three dimensions are investigated by computer simulations. We give a coherent and quantitative explanation of the dynamics in terms of continuum percolation theory and obtain an excellent matching of the critical density and exponents. Within a dynamic scaling ansatz incorporating two divergent length scales we achieve data collapse for the mean-square displacements and identify the leading corrections to scaling. We provide evidence for a divergent non-Gaussian parameter close to the transition.

Journal Article↗

PubMed2005

Renewal processes and fluctuation analysis of molecular motor stepping.

We present a systematic method of analysis of experiments performed with single motor proteins. The use of such a method should allow a more detailed description of the motor's chemical cycle through the precise fitting of the experimental data. We model the dynamics of a processive or rotary molecular motor using a renewal process, in line with the work initiated by Svoboda, Mitra and Block. We apply a functional technique to compute different types of multiple-time correlation function of the renewal process, which have applications to bead-assay experiments performed both with processive molecular motors, such as myosin V and kinesin, and rotary motors, such as F1-ATPase.

Kinesins↗

PubMed2004

Collective phenomena in intracellular processes.

Intracellular transport and cytoskeletal organization are the result of an interaction between elastic filaments and force generation by motor proteins. The observed phenomena are still too complex for a complete theoretical description. Studies on simple model systems reveal interesting collective phenomena which can be understood on the basis of driven stochastic processes far from equilibrium.

Animals↗