Biomedical subjects

Thomas Griffin

Publications and source records attributed to Thomas Griffin.

5 recordsLinked to original sources

PubMed2005

Angiolymphoid hyperplasia successfully treated with an ultralong pulsed dye laser.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vascular proliferation characterized by dermal or subcutaneous nodules or both, primarily in the head and neck. We report the successful treatment of ALHE without scarring using a 595 nm ultralong pulsed dye laser, which applies a unique combination of longer wavelengths, a longer pulse duration, and a higher fluence. OBJECTIVE: To report the use of the 595 nm pulsed dye laser in the treatment of ALHE and to detail the particular aspects of this laser that make it uniquely qualified to treat this entity. METHODS: Case report and review of the literature. RESULTS AND CONCLUSION: This laser may be used as an effective treatment for ALHE and has advantages over alternative treatments and older lasers. Specifically, the longer wavelength (595 nm) penetrates more deeply into dermal tissue, which produces more uniform coagulation across the entire vessel.

Aged↗

PubMed2005

Potential impact of antiviral drug use during influenza pandemic.

The recent spread of highly pathogenic strains of avian influenza has highlighted the threat posed by pandemic influenza. In the early phases of a pandemic, the only treatment available would be neuraminidase inhibitors, which many countries are considering stockpiling for pandemic use. We estimate the effect on hospitalization rates of using different antiviral stockpile sizes to treat infection. We estimate that stockpiles that cover 20%-25% of the population would be sufficient to treat most of the clinical cases and could lead to 50% to 77% reductions in hospitalizations. Substantial reductions in hospitalization could be achieved with smaller antiviral stockpiles if drugs are reserved for persons at high risk.

Adolescent↗

PubMed2002

Dispositions, scripts, or motivated correction? Understanding ideological differences in explanations for social problems.

Research has consistently found that liberals and conservatives generate different attributions for the causes of social problems and respond differently to people who have internal-controllable causes for needing help. Five studies using a variety of methods (the "college bowl" paradigm, the attitude-attribution paradigm, 2 surveys with nationally representative samples, and an experiment that assessed attributional judgments under varying levels of cognitive load) explored whether these differences could be explained by (a) underlying dispositional differences in the tendency to see the causes of behavior as personally or situationally located, (b) ideological scripts, or (c) differences in the motivation to correct personal attributions. Results were most consistent with the motivated correction explanation. The findings shed further light on the cognitive strategies and motivational priorities of liberals and conservatives.

Analysis of Variance↗

PubMed2002

Tissue micro-array: a cost and time-effective method for correlative studies by regional and national cancer study groups.

Tissue micro-arrays have been used for molecular and immunohistochemical studies. We sought to evaluate whether such arrays could substitute for whole sections in correlative studies performed by the Radiation Therapy Oncology Group. Four multitumor 150-sample arrays were built using formalin-fixed, paraffin-embedded, archival prostate, brain, and head/neck tumor blocks from RTOG tissue bank. p53 immunostaining of arrays and whole sections was done. Blind evaluation of each slide was made, and agreement rates between the two techniques were determined in various scenarios. Cost was also evaluated. Results demonstrate excellent agreement for p53 between slides and arrays. Agreement improved when three or four replicate arrays were used. Findings based on one to four arrays agree well with those obtained from analysis of the whole tissue samples. Minimal tissue damage, improved tissue salvage, cost reduction, ease of interpretation, and significant time savings were realized by using the arrays. Tissue micro array technique is a valuable tool for evaluation of patient materials associated with clinical trials.

Head and Neck Neoplasms↗

PubMedDate not supplied

A novel GJA 1 mutation in oculo-dento-digital dysplasia with curly hair and hyperkeratosis.

Oculo-dento-digital dysplasia (ODDD) is a rare autosomal dominant congenital disorder mainly affecting the development of the face, eyes, skeletal system, heart and dentition. ODDD has been mapped to chromosome 6q22-q24 and germline mutations have been identified in the connexin 43 gene, GJA1. Abnormalities of the skin, hair, and nails have been recognized in ODDD but are often easily overlooked. We report an ODDD patient with curly hair, early trichorrhexis nodosa and discrete keratoderma. Molecular genetic studies revealed a novel GJA1 mutation affecting the amino terminus of the gap junction protein alpha-1 (Cx43). In the light of the cutaneous findings in our patient and based on recent ectodermal dysplasia classification systems, we propose to include ODDD in the group of ectodermal dysplasias.

Abnormalities, Multiple↗