Submacular surgery trials update.
Submacular surgery is a method of therapy for subfoveal CNV from multiple causes. It was first reported in the late 1980s. Since then, refinements in patient selection and surgical technique have reduced complications and made it a viable alternative to existing treatments and natural history for this condition. The Submacular Surgery Trials (SST) is a series of prospective, randomized, multicenter clinical trials designed to evaluate submacular surgery for exudative and hemorrhagic subfoveal CNV from AMD and for exudative subfoveal CNV from OHS and idiopathic causes. Recruitment has been completed for these trials, and the DSMC is continuously monitoring safety and efficacy and evaluating any modifications of study design to accommodate new therapies for subfoveal CNV.