Biomedical subjects

Tian-de Yang

Publications and source records attributed to Tian-de Yang.

3 recordsLinked to original sources

PubMed2006

Effect of terbutaline on alveolar liquid clearance after oleic acid-induced lung injury in rats.

OBJECTIVE: To investigate whether terbutaline affects alveolar liquid clearance after oleic acid-induced lung injury in rats. METHODS: Forty healthy Wistar rats (weighing 250-280 g) were randomly divided into five groups (n=8 in each group): the normal control group (control group), oleic acid injury group (injury group), terbutaline-treated group (terbutaline group), terbutaline plus amiloride-treated group (terbutaline+amiloride group) and terbutaline plus ouabain-treated group (terbutaline+ouabain group). Acute lung injury model was induced by intravenous oleic acid (0.25 ml/kg body weight). 24 hours later, 1.5 microCi (125) I-labeled 5% albumin solution (5 ml/kg body weight) was dripped into the lungs through trachea. The alveolar liquid clearance rate, extravascular lung water content, and arterial blood gas were measured 1 hour thereafter. RESULTS: At 24 hours after infusion of oleic acid, the rats developed pulmonary edema and severe hypoxemia, with the alveolar liquid clearance rate decreased by 49.2% and the extravascular lung water content elevated by 47.9%. Compared with the rats in the injury group, terbutaline (10(-4) mol/L) significantly increased the alveolar liquid clearance rate, decreased the extravascular lung water content and improved hypoxemia. The effect of terbutaline was partly blocked by amiloride and ouabain, which were inhibitors of sodium transport. Terbutaline increased the alveolar liquid clearance rate by 63.7%, and amiloride and ouabain reduced the alveolar liquid clearance rate by 54.7% and 56.8%, respectively. CONCLUSIONS: Terbutaline can accelerate alveolar liquid clearance through increasing sodium transport to attenuate pulmonary edema, thus improving gas exchange, which may have therapeutical effect on pulmonary edema after acute lung injury.

Adrenergic beta-Agonists↗

PubMed2004

Changes in liquid clearance of alveolar epithelium after oleic acid-induced acute lung injury in rats.

OBJECTIVE: Impaired active fluid transport of alveolar epithelium may involve in the pathogenesis and resolution of alveolar edema. The objective of this study was to explore the changes in alveolar epithelial liquid clearance during lung edema following acute lung injury induced by oleic acid. METHODS: Forty-eight Wistar rats were randomly divided into six groups, i.e., injured, amiloride, ouabain, amiloride plus ouabain and terbutaline groups. Twenty-four hours after the induction of acute lung injury by intravenous oleic acid (0.25 ml/kg), 5% albumin solution with 1.5 microCi (125)I-labeled albumin (5 ml/kg) was delivered into both lungs via trachea. Alveolar liquid clearance (ALC), extravascular lung water (EVLW) content and arterial blood gases were measured one hour thereafter. RESULTS: At 24 h after the infusion of oleic acid, the rats developed pulmonary edema and severe hypoxemia, with EVLW increased by 47.9% and ALC decreased by 49.2%. Addition of either 2x10(-3) M amiloride or 5x10(-4) M ouabain to the instillation further reduced ALC and increased EVLW. ALC increased by approximately 63.7% and EVLW decreased by 46.9% with improved hypoxemia in the Terbutaline (10(-4) M) group, compared those in injured rats. A significant negative correlation was found between the increment of EVLW and the reduction of ALC. CONCLUSIONS: Active fluid transport of alveolar epithelium might play a role in the pathogenesis of lung edema in acute lung injury.

Adrenergic beta-Agonists↗

PubMed2002

[Body temperature changes during 7 d -6 degrees head-down bed rest].

Objective. To investigate body temperature changes in man during 7-day -6 degrees head-down bed rest (BR). Method. Body temperatures were measured in the morning (6:00), afternoon (16:00) and evening (20:00) during 7 d BR in 18 healthy males (18-22 years old). Result. Rectal temperature (Tre) in the morning gradually decreased as time (d) of BR increased: after the 4th day of BR (BR4d), Tre significantly reduced compared with the supine control (SC, 36.50 +/- 0.03 degrees C) before BR, and it consistently declined to 36.38 +/- 0.04 degrees C on BR7d; But Tre significantly increased in the afternoon after BR5d and in the evening after BR1d, with the final increments of 0.12 +/- 0.05 degrees C and 0.25 +/- 0.03 degrees C respectively on BR7d. Mean body temperature (Tsk) in the morning was significantly higher from BR2d than its SC, with a final net increase (delta Tsk) of 0.38 +/- 0.14 degrees C on BR7d. And Tsk significantly increased in the afternoon and evening from BR4d, BR2d respectively. Skin temperature on the forehead (Tforehead) elevated in the morning during BR. While in the afternoon and evening, Tforehead were significantly higher from BR7d and BR6d than their SC. Conclusion. Both the difference in time of recording at a BR day and the time (d) of BR have significant influence on Tre, Tsk , and Tforehead (P<0.01). These data suggest that body temperature rhythm, body fluid loss and headward distribution, hypokinesis etc. induced by BR have an impact on human thermal regulation during BR.

Adolescent↗