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Tianming Wang

Publications and source records attributed to Tianming Wang.

11 recordsLinked to original sources
PubMed2026

Efficacy and safety of microwave ablation for the treatment of pulmonary osteosarcoma oligometastases.

PURPOSE: Evaluate efficacy and safety of microwave ablation (MWA) for pulmonary osteosarcoma oligometastases. METHODS: Twenty-two patients (median age, 16 years [range, 9-41 years]; 15 male) with pulmonary osteosarcoma oligometastases who underwent MWA from January 2018 to December 2023 were included, with 27 MWA sessions for 36 lung metastases. Technical success and complications were evaluated in all 22 patients, while efficacy and survival were evaluated in 19 patients with 24 MWA sessions in treatment of 32 tumors. Technical success was assessed for each tumor. Local tumor control, progression-free survival (PFS) and overall survival (OS) were estimated using Kaplan-Meier method. Complications were classified using Common Terminology Criteria for Adverse Events version 5.0. RESULTS: Technical success was achieved in all 36 tumors (100.0%). Local tumor progression occurred in five of 32 tumors (15.6%). The estimated local tumor control rates at 12, 24 and 36 months were 96.9%, 86.1% and 81.5%, respectively. No significant difference in local control was found between tumors ≤ 10 mm and > 10 mm (p = .470). Twelve of 19 patients (63.2%) developed new lung metastases outside the ablation area, including one with concurrent newly developed bone metastases and one with recurrence of primary osteosarcoma. The median PFS was 21.5 months. The estimated OS rates at 12, 24 and 60 months were 100.0%, 94.4% and 94.4%, respectively. Major complications occurred in five of 27 sessions (18.5%). CONCLUSIONS: MWA preliminarily demonstrates a high technical success rate, notable local tumor control, promising overall survival and acceptable safety for pulmonary osteosarcoma oligometastases.

Adolescent↗
PubMed2007

A solid-phase extraction method for high-performance liquid chromatographic determination of salvianolic acid B in rabbit plasma: application to pharmacokinetic study.

A sensitive solid-phase extraction/high-performance liquid chromatographic method with ultraviolet detection was established for the analysis of salvianolic acid B in rabbit plasma. The analyte was separated on a reversed-phase column with trifluoroacetic acid-methanol-acetonitrile (70:10:20, v/v/v) as mobile phase at a flow rate of 1 mL/min, and ultraviolet detection at 315 nm. The calibration curve for salvianolic acid B was linear over the range 35-1400 microg/L with coefficients of correlation >0.999. The inter-day and intra-day precisions of analysis were <15%, and assay accuracy ranged from 95.3 to 109.1%. This method is suitable for determining salvianolic acid B in plasma and thus investigating the pharmacokinetics of salvianolic acid B.

Animals↗
PubMed2006

A method for rapid similarity analysis of RNA secondary structures.

BACKGROUND: Owing to the rapid expansion of RNA structure databases in recent years, efficient methods for structure comparison are in demand for function prediction and evolutionary analysis. Usually, the similarity of RNA secondary structures is evaluated based on tree models and dynamic programming algorithms. We present here a new method for the similarity analysis of RNA secondary structures. RESULTS: Three sets of real data have been used as input for the example applications. Set I includes the structures from 5S rRNAs. Set II includes the secondary structures from RNase P and RNase MRP. Set III includes the structures from 16S rRNAs. Reasonable phylogenetic trees are derived for these three sets of data by using our method. Moreover, our program runs faster as compared to some existing ones. CONCLUSION: The famous Lempel-Ziv algorithm can efficiently extract the information on repeated patterns encoded in RNA secondary structures and makes our method an alternative to analyze the similarity of RNA secondary structures. This method will also be useful to researchers who are interested in evolutionary analysis.

Algorithms↗
PubMed2006

Protein-based phylogenetic analysis by using hydropathy profile of amino acids.

So far, various approaches for phylogenetic analysis have been developed. Almost all of them put stress on analyzing nucleic acid sequences or protein primary structures. In this paper, we take the physicochemical properties of amino acids into account and introduce the hydropathy profile of amino acids into phylogenetic analysis. We find that this introduction is effectual and our method may be used to complement phylogenetic analysis.

Amino Acids↗
PubMed2006

A simple method for protein structural classification.

Since the concept of structural classes of proteins was proposed, the problem of protein classification has been tackled by many groups. Most of their classification criteria are based only on the helix/strand contents of proteins. In this paper, we proposed a method for protein structural classification based on their secondary structure sequences. It is a classification scheme that can confirm existing classifications. Here a mathematical model is constructed to describe protein secondary structure sequences, in which each protein secondary structure sequence corresponds to a transition probability matrix that characterizes and differentiates protein structure numerically. Its application to a set of real data has indicated that our method can classify protein structures correctly. The final classification result is shown schematically. So it is visual to observe the structural classifications, which is different from traditional methods.

Algorithms↗
PubMed2006

PNN-curve: a new 2D graphical representation of DNA sequences and its application.

We introduce a novel 2D graphical representation of DNA sequences based on the pairs of the neighboring nucleotides (PNNs). Then we get the PNNs' distributions and obtain a y-M. The construction of the PNN-curve has some important advantages (1) It avoids loss of information and the PNN-curve standing for DNA sequences does not overlap or intersect with itself. (2) The novel 2D representation is more sensitive. The utility of this method can be illustrated by the examination of similarities/dissimilarities among the coding sequences of the first exon of beta-globin gene of eleven different species in Table 2.

Animals↗
PubMed2006

A weighted measure for the similarity analysis of DNA sequences.

Here we propose a weighted measure for the similarity analysis of DNA sequences. It is based on LZ complexity and (0,1) characteristic sequences of DNA sequences. This weighted measure enables biologists to extract similarity information from biological sequences according to their requirements. For example, by this weighted measure, one can obtain either the full similarity information or a similarity analysis from a given biological aspect. Moreover, the length of DNA sequence is not problematic. The application of the weighted measure to the similarity analysis of beta-globin genes from nine species shows its flexibility.

Animals↗
PubMed2006

A novel 2D graphical representation of DNA sequences and its application.

In this paper, we introduce a novel 2D graphical representation of DNA sequences, the W-curve, which is embedded in two unit circles. We associate the W-curves with the classifications of the nucleotides according to their chemical properties. Then we obtain an 8-component vector with entries being the average sums of the abscissa and y-axis of A+C and T+G (A+T and C+G, A+G and T+C), respectively. The introduced vector results in simpler characterizations and comparisons of DNA sequences. The construction of the W-curve has some important advantages: (1) it avoids loss of information and the W-curve standing for DNA doesn't overlap or intersect itself; (2) the space the W-curve occupied is very small, just two unit circles. The utility of the approach can be illustrated by the examination of similarities/dissimilarities among the coding sequences of the first exon of beta-globin gene of eleven different species in Table 1.

Base Pairing↗
PubMed2006

2D representation of protein secondary structure sequences and its applications.

In terms of the classification of the protein secondary structures, we propose a 2D representation of protein secondary structure sequences. The representation are used to display, analyze, and compare the secondary structure sequences. Based on this representation, we assign the structural class to the protein, and verify the advantage or disadvantage of the methods of predicted protein second structure.

Amino Acid Sequence↗
PubMed2005

[Landscape ecological evaluation of Fenglin Nature Reverse: quantification and interpretation].

Fenglin National Class Nature Reserve is the largest well-saved virginal Korean pine (Pinus koraiensis) forest area and a precious species gene bank in China. In this study, the indexes diversity, naturalness, representativity, rarity, area suitability, stability, and anthropogenic interference were selected to establish a ranking ecological evaluation system to estimate the ecological condition of the Reserve. The value of each index was determined by the evaluation system, and the weight percentage was decided by Analytical Hierarchy Process (AHP). In the Reserve, there were 568 higher plant species belonging to 113 families and 220 higher animal species, with score 3 of species diversity. The zonal "climax" vegetation type broad-leaved Korean pine forest and the intrazonal community type spruce-fir forest constituted the principal part of the Reserve forest, which was the epitome of the virgin broad-leaved Korean pine forest in Lesser Xing'an Mountains, with representativity score 3. During the past 20-30 years, the natural habitat in the Reserve was quite good, and secondary succession was obtained effective control with few natural or anthropogenic disturbance, with score 4 of naturalness and anthropogenic interference. There were a lot of ancient species of the tertiary period, such as Pinus koraiensis, Fraxinus mandsurica, Juglans mandshurica, Pellodendron amurense, Tilia amurensis and Acer mono, and Pinus koraiensis was listed as one of severe danger species by the FAO of UN, with rarity score 4. The Reserve covered an area of 18165 hm2, with an enough size to maintain the structure and function of the ecosystem. Accordingly, its area suitability score was 4. Broad-leaved Korean pine forest was the most typical and stable vegetation type in the Reserve, and thus, its stability score was 4. Finally, the composite evaluation index (CEI) was figured out as 0.87, showing that the ecological quality of the Reserve was very good, and the protection value was quite high. In conclusion, the present area, structure, and management of the Reserve could satisfy the requirement of sustainable development.

Biodiversity↗