PubMed Health⌕ Search

Biomedical subjects

Tibor Oláh

Publications and source records attributed to Tibor Oláh.

3 recordsLinked to original sources

[Esophageal operations with thoracoscopy].

Between 01.07.1992 and 30.06.1997 we performed thoracoscopic esophagomyotomies in seven patients suffering from achalasia cardiae, and 6 thoracoscopic mobilization of the esophagus because of esophageal cancer. The necessary background for thoracoscopic operations are: practice in minimally invasive surgery, isolated intubation, appropriate instrumentation and readiness for immediate thoracotomy. Following the myotomy, oral feeding started on the 2nd postoperative day. The mean discharge of the patients was on the 6th postoperative day. We compared the pre- and post-operative conditions 6 weeks following the operation x-ray, esophago-gastroscopy, manometry, pH-measurements were performed. Good result of the operations were: all examinations showed marked improvement and all patients had better swallowing and 3 to 9 kg increase of body weight. Thoracoscopic mobilization has been attempted on nine occasions. Thoracotomy was necessary in 3 patients because of a perforation of the left main bronchus, bleeding and tumor infiltration to surrounding areas. The mean mobilization time was 4 hours, but the time original 6 hours with practice was reduced to less than 3 hours. One patient died because of pulmonary complication, recovery of other patients was uneventful.

Adult↗

[The role of laparoscopy in the surgical treatment of colorectal cancer. Initial results].

The authors have carried out laparoscopically assisted abdomino-perineal rectal resections on a selected group of 8 patients during the past two years. The laparoscopic technique was not accompanied by any complications, while the patients enjoyed the benefits of the procedure. The bowel function of the patients were restored on the 2nd to 3rd day, the mean length of the hospital stay was 8.3 days. On the basis of their own favourable initial experience and recent literature data, the authors discuss the benefits, disadvantages and pitfalls of the laparoscopically assisted technique for surgical treatment of colorectal cancer. The problematics of oncological radicality is analysed.

Adenocarcinoma↗

Opposite effects of serotonin and interferon-alpha on the membrane potential and function of human natural killer cells.

In an earlier article, we reported that serotonin (5-hydroxytryptamine, 5-HT) inhibits the natural killer cell (NK) cytotoxicity of human whole blood in a dose-dependent manner and that natural human interferon-alpha (IFN-alpha) partially eliminates this effect. Because natural IFN-alpha might contain factors other than IFN, we repeated these experiments with recombinant human interferon-alpha (rhIFN-alpha) and separated blood lymphocytes enriched with NK cells and then demonstrated that IFN really is responsible for this effect. Furthermore, this investigation was carried out to clarify the mechanisms of the action of 5-HT and of rhIFN-alpha on NK cells. The inhibition of the cytotoxicity was pronounced when 5-HT was added at the onset of the cytotoxic assay, whereas the pretreatment of lymphocytes for 18 h only led to a slight inhibition. Moreover, rhIFN-alpha applied 1 h before or 1 h after the addition of 5-HT decreased the inhibitory effect of 5-HT. Flow cytometric analysis involving the use of a voltage-sensitive dye, oxonol, revealed that 5-HT depolarized, whereas rhIFN-alpha hyperpolarized the plasma membrane of the lymphocytes. Thus, it seems likely that the inhibitory effect of 5-HT on the cytotoxicity of peripheral human lymphocytes is due to the depolarization on the plasma membrane of the effector cells and that rhIFN-alpha antagonizes this ability via its hyperpolarizing activity.

Cytotoxicity Tests, Immunologic↗