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Biomedical subjects

Tim La H Brown

Publications and source records attributed to Tim La H Brown.

18 recordsLinked to original sources
PubMed2006

Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands.

Recent data from murine models have confirmed that Langerhans cells are not the only population of APCs in the skin involved in initiating immune responses. In healthy human skin, we identify CD1a(+) dermal APCs located close to the lymphatic vessels in the upper layers of the dermis that are unequivocally distinct from migrating Langerhans cells but exhibit both potent allostimulatory capacity and a chemotactic response to CCR7 ligands. In contrast, CD14(+) dermal APCs are distributed throughout the dermis and lack a chemotactic response to CCR7 ligands. CD1a(+) dermal APCs therefore represent an APC population distinct from Langerhans cells that are capable of migrating to lymph nodes and stimulating naive T cells. In humans, CD1a(+) dermal APCs may fulfill some of the roles previously ascribed to Langerhans cells.

Antigen Presentation↗
PubMed2005

Management of high voltage electrical injury in children.

High voltage electrical injuries in children are rare. They produce severe internal damage to limbs resulting in a high incidence of amputation. Early, aggressive serial debridement ensures adequate removal of dead tissue. Flap coverage to defects is necessary. Secondary surgery is common, and delayed sequelae such as tendon rupture should be expected.

Abdomen↗
PubMed2005

Long term functional outcomes and quality of life following severe burn injury.

This study was designed to examine functional and psychological outcome of severely burned patients adults. Adult patients (n=38) admitted to the Royal Brisbane hospital with burns >40% TBSA were assessed two years post injury using the Abbreviated BSHS and a supplemental questionnaire relating to specific physiotherapy and occupational health issues. An average return to driving occurred at 36 weeks and return to work at 51 weeks. Involvement of the hands and face significantly altered the physical domain of the questionnaire and the sub-domain examining role. Genital burns altered the sexual sub-domain, but this was not gender dependant. Mobility and self care were significantly altered when a burn was >20% TBSA full thickness. The study demonstrates that these patients can develop functional independence and good quality of life. The long term outlook for patients with large burns is generally positive. Consequently, burn care professionals can be reassured that the effort is worthwhile.

Adolescent↗
PubMed2005

Burn injury care for Special Forces and far-forward deployed troops.

Special Forces are at risk of serious burn injury. We have suggested standard operating procedures for burn injury management in a constrained environment, with novel uses of operational kit components for trauma care. In addition, we propose instruction in basic skills of escharotomy for forward troops.

Brain Injuries↗
PubMed2004

Re-evaluating selection criteria for local anaesthesia in day surgery.

Day surgery is an increasing element of surgical practice, particularly in plastic surgery. A large proportion of work is undertaken using local anaesthesia in the elderly who have associated co-morbidity. At present no national guidelines exist for the use of local anaesthesia in day surgery. This study aimed to examine the relationship between patient selection and complications, in order to identify those who should be excluded from local anaesthetic day surgery treatment. A retrospective analysis of patients undergoing local anaesthetic plastic surgical procedures over a 10-month period identified 328 operative episodes. There were 37 complications, two of which required admission 5 days post surgery for treatment of wound infection. The remaining complications were treated on an outpatient basis. An increased level of complication was seen in males with elevated systolic blood pressure and with the use of full thickness skin grafts in reconstruction. Age, smoking, ASA grade, and medication that altered coagulation (aspirin, warfarin and steroids) were not associated with increased complication levels. We conclude that local anaesthetic plastic surgical procedures are associated with a very low level of risk, and are suitable for those patients traditionally regarded as unsuitable for general anaesthetic day surgery.

Adolescent↗
PubMed2004

Reduced hospitalisation of burns patients following a multi-media campaign that increased adequacy of first aid treatment.

CONTEXT: Concern engendered by a previous study that showed inadequate first aid for burn injuries was prevalent in the community led to a novel multi-media public health campaign ensued to address the issue. OBJECTIVE: To determine whether this public health campaign influenced behaviour by altering first aid treatment for burn injuries (BFAT). DESIGN, SETTING AND POPULATION: Prospective intervention study. Consecutive patients with acute burn injuries over two 4-month intervals, presenting to a regional burn service, Auckland, New Zealand. This research was ethically approved by the Local Research Ethics Committee. MAIN OUTCOME MEASURES: Demographics, burn size, adequacy of burn first aid, outpatient/inpatient wound care and operative intervention requirement. RESULTS: Adequacy of BFAT improved following the campaign (59% versus 40%, P=0.004). Fewer inpatient admissions (64.4% versus 35.8%, P<0.001) and surgical procedures (25.6% versus 11.4%, P<0.001) were undertaken following the campaign with a corresponding increase in outpatient care. Greatest decreases were observed in Maori and Pacific Islanders, and in children <10 years old. CONCLUSIONS: Adequacy of BFAT together with a reduction in the numbers of patients requiring inpatient surgical care was improved by a multi-media public awareness campaign.

Adolescent↗
PubMed2004

Suction dressings to secure a dermal substitute.

One of the problems with the dermal substitute Integra has been securing the material to the wound bed to prevent shearing and loss. Techniques to achieve stability include staples and elastic netting with an over layer of absorbent dressings that can be changed regularly. We report an effective technique using suction dressings to immobilise Integra. This technique led to firm application underlying tissue, and appeared to decrease fluid collection under the Integra. Earlier mobilisation and discharge from hospital were facilitated.

Bandages↗
PubMed2004

Where are all the burn surgeons? A survey of plastic surgical trainees in Australasia.

There is a world shortage of burn surgeons. A questionnaire survey of all plastic surgical trainees in Australasia was conducted at a recent training event. 10/48 trainees would consider burns as a major subspecialty interest. A good experience of burn care whilst training seems to be important in influencing trainees consider it as a career choice. The perception of a career as a burn surgeon is poor, and requires some urgent attention.

Attitude of Health Personnel↗
PubMed2004

Damage limitation in burn surgery.

Burn injury differs from other types of trauma in the apparent lack of urgency for treatment. We argue that in order to limit physiological damage and the development of multi-organ failure, management of the burn wound must be immediate and aggressive. Supportive fluid treatment should be judicious in order to prevent excessive oedema causing wound extension. Some potential strategies utilising oral fluid resuscitation are discussed, and potential pharmacological interventions. When associated with other trauma, major burn injury has a detrimental effect on morbidity and mortality, and surgical management of both aspects of a patient's injuries are altered.

Burns↗
PubMed2003

Incidence of vomiting in burns and implications for mass burn casualty management.

When faced with large numbers of burn patients and limited resources such as in war or disaster, oral fluids may be used as an alternative to intravenous resuscitation. Vomiting during the first 48 h can limit the usefulness of this method; yet its incidence has not been documented. This study aimed to identify those patients at risk of vomiting following burn injury and who therefore might be suitable for oral resuscitation. A retrospective review of case notes from burn patients between 1990 and 2001 was undertaken. Burns requiring intravenous resuscitation (>10% total body surface area (TBSA) in children, >15% TBSA in adults) were included (n=110). Documentation of vomiting during the first 48 h following burn injury to an extent that prevented commencement of feeding was regarded as significant. Patients that vomited were significantly older (28.3 years compared with 18.5 years, P=0.03), and had sustained significantly larger burns (29.8% compared with 22.9%, P=0.047). Administration of opiates and anti-emetics was similar in both groups and not significant. Although the number of patients in this study excludes a logistic regression analysis, it would seem reasonable to attempt oral resuscitation in patients under 25 years of age and with burns up to 25% TBSA given limited resources.

Adolescent↗
PubMed2003

Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin.

Inhibition of wound contraction by topical anti microbial agents has been described. The purpose of this study was to further investigate that phenomenon and to explore the effect that other agents such as Aloe vera might have on this process. Full-thickness excised wounds were created on the dorsum of Sprague-Dawley rats under anaesthesia. The wounds were treated with topical agents three times daily for fourteen days, then observed until healed. Groups were: saline control, placebo (aqueous cream) control, silver sulphadiazine (SSD) cream 1%, SSD 0.5%, SSD 1% with Aloe vera, SSD 1% with nystatin, nystatin. Wound surface areas were measured each three days. Time to 50% and 90% healing was compared using ANOVA. Wound half-life and healing times were shortest in the SSD/Aloe vera and nystatin groups (P<0.05) and longest in the 1% SSD and saline control groups. The placebo group (aqueous cream) healed in a significantly shorter time (P<0.05) than the control (saline) group. Wound contraction was delayed by saline and SSD. Nystatin and Aloe vera, when added to SSD, reversed that effect. These data suggest that a dry wound (saline) heals slowly. Infection control without delay of wound healing is most appealing and clinical trials are planned.

Administration, Topical↗