Images in cardiovascular medicine. Myocardial bridging.
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Angioplasty, Balloon, Coronary↗
Biomedical subjects
Tim Leiner
Publications and source records attributed to Tim Leiner.
Regarding "Improvement in the visualization of superficial arm veins being evaluated for access and bypass".
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Arm↗
Forearm cephalic vein cross-sectional area changes at incremental congestion pressures: towards a standardized and reproducible vein mapping protocol.
OBJECTIVES: Duplex ultrasonography assessment of superficial forearm veins is frequently used before a hemodialysis arteriovenous fistula (AVF) is created. There is, however, no standardized preoperative duplex ultrasonography protocol. This study assessed B-mode image analysis reproducibility and reproducibility of repeated forearm superficial venous diameter measurements on different days at different venous congestion pressures (VCPs). METHODS: Diameters were determined using B-mode ultrasonography in 10 healthy male volunteers on days 1 and 14 at incremental VCP values (10 to 80 mm Hg). Intra- and interobserver agreement was assessed for B-mode image analysis by calculating interclass correlation coefficients (ICC). Reproducibility of repeated diameter measurements (maximum and minimum diameter at days 1 and 14), cross-sectional area size increase, and shape change due to incremental VCPs were determined by calculating ICC values. RESULTS: Analysis of intraobserver agreement of B-mode image interpretation yielded ICC values of 0.97 (95% confidence interval [CI], 0.94 to 0.99) and 0.97 (95% CI, 0.96 to 0.99) for determination of maximum and minimum diameters, respectively. Interobserver agreement analysis yielded ICC values of 0.95 (95% CI, 0.92 to 0.97) and 0.96 (95% CI, 0.96 to 0.99) for determination of maximum and minimum diameters, respectively. Reproducibility of repeated diameter measurements on days 1 and 14 improved substantially at incremental VCP values, with best reproducibility at VCPs >40 mm Hg. Repeated determination of cross-sectional area size increase and shape change due to VCP increase from 10 to 80 mm Hg yielded ICC values of 0.49 (95% CI, 0.19 to 1.00) and 0.09 (95% CI, 0.00 to 0.92), respectively. Maximum and minimum diameters as well as cross-sectional area size increased significantly (P < .01) due to VCP increase during both sessions. Cross-sectional area shape changed significantly (P < .01) due to VCP increase during both sessions. CONCLUSIONS: Diameter measurements on B-mode images are largely observer independent. Superficial venous cross-sectional area shape is noncircular, and cross-sectional area size depends on VCP. Both maximum and minimum venous diameters should be determined at VCPs >40 mm Hg to attain the best reproducibility. Further studies are needed to determine whether a standardized preoperative vein mapping protocol can reduce AVF nonmaturation rates.
Adult↗
Diameter measurements of the forearm cephalic vein prior to vascular access creation in end-stage renal disease patients: graduated pressure cuff versus tourniquet vessel dilatation.
BACKGROUND: Preoperative assessment of forearm superficial venous diameter may predict early failure of newly created arteriovenous fistulas for haemodialysis access. However, early failure and non-maturation rates remain high (up to 30%) and reported cut-off diameters are inconsistent. We hypothesize that this inconsistency is due to differences in the methods used to achieve venous dilatation prior to diameter measurements and daily variation in superficial venous diameter. We furthermore hypothesize that the use of a cuff will lead to a better inter-observer agreement since the applied pressure can be precisely determined. The purpose of this study was to determine inter-observer agreement of superficial venous diameter measurement under venous congestion by using either a graduated pressure cuff or tourniquet and furthermore, to determine daily variations in superficial venous diameter. METHODS: Diameter measurements were performed by two observers on days 1 and 3, in 21 end-stage renal disease patients using either a cuff (60 mmHg) or tourniquet. Measurements were carried out in random order and observers were blinded for each other's results. Inter-observer agreement was expressed as interclass correlation coefficients. Variance components analysis was used to determine possible causes of disagreement. RESULTS: Using a cuff, mean venous diameter was 1.8 mm (range, 0.7-3.3 mm). When a tourniquet was used, the mean diameter was 1.8 mm (range, 0.6-3.2 mm). Interclass correlation coefficients between observers were 0.76 and 0.74 for the use of a cuff and tourniquet, respectively. Diameter measurements were revealed to be observer independent. Variations in venous diameter were determined by the patient and the interaction of patient and day. Repeated assessment of venous diameter on different days revealed a variation coefficient of 26.4% when using a cuff, and 26.5% when using a tourniquet. CONCLUSIONS: Venous diameter assessment is observer and congestion method independent. Daily variations in forearm superficial venous diameters should be taken into account when defining and using cut-off diameters prior to vascular access surgery.
Adult↗
Diagnosis of abdominal aortic hypoplasia by state-of-the-art MR angiography.
Abdominal aortic hypoplasia is a rare vascular variant with possible major clinical sequelae when the renal arteries are also involved. The condition is thought to result from embryonic overfusion of the two dorsal aortas. The diagnosis may be considered in patients presenting with hypertension in the neonatal period and severely reduced or absent arterial pulses in the groin. We present contrast-enhanced state-of-the-art magnetic resonance angiography imaging findings in an 8-year-old boy with abdominal aortic hypoplasia.
Aorta, Abdominal↗
Contrast-enhanced peripheral MR angiography using SENSE in multiple stations: feasibility study.
PURPOSE: To investigate if the use of parallel imaging is feasible and beneficial for peripheral contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS: A total of 19 consecutive patients underwent peripheral CE-MRA using SENSE with two-fold reduction in the upper and lower leg stations. Conventional nonaccelerated imaging using constant level appearance (CLEAR) was used in the aortoiliac station. The findings were compared with those in a similar patient group that underwent peripheral CE-MR angiography using our standard imaging protocol without SENSE. Intraarterial digital subtraction angiography (IA-DSA) was used as the standard of reference. Lower extremity vessels were divided into anatomic segments (aortoiliac, upper legs, lower legs) for review. In each anatomic segment signal- and contrast-to-noise ratios (SNR, CNR), venous contamination, subjective image quality, as well as sensitivity and specificity, were determined for both patient groups. RESULTS: SNR and CNR improved significantly for the aortoiliac and upper leg segments (all P-values < or = 0.001). Small reductions were seen in the frequency of disturbing venous enhancement (P = not significant). There were no significant differences with regards to subjective image quality or diagnostic accuracy (all P > 0.3). Overall sensitivity and specificity in the SENSE group were 81% and 95%, respectively. For the non-SENSE group, these values were 79% and 96%, respectively. CONCLUSION: Preliminary results show that three-station peripheral CE-MRA using a full length peripheral arterial coil in combination with SENSE in the upper and lower leg stations is feasible and useful for further optimization of peripheral MRA. Using SENSE allows for routine, high-quality depiction of the entire peripheral vascular tree including the pedal arch. Higher SENSE factors are needed for further optimization.
Aged↗
Comparison of 0.5-M Gd-DTPA with 1.0-M gadobutrol for magnetic resonance angiography of the supplying arteries of the spinal cord in thoracoabdominal aortic aneurysm patients.
PURPOSE: To prospectively compare 0.5-M gadopentetate dimeglumine (Gd-DTPA) with 1.0-M gadobutrol for contrast-enhanced magnetic resonance angiography (CE-MRA) of the blood supplying arteries of the spinal cord in patients referred for open surgical repair of a thoracoabdominal aortic aneurysm (TAAA). MATERIALS AND METHODS: A total of 11 patients with a TAAA underwent two three-dimensional CE-MRA exams of the aorta, segmental arteries (SAs), artery of Adamkiewicz (AKA), and anterior spinal artery (ASA). Imaging was performed on two separate occasions using Gd-DTPA and gadobutrol as contrast agents at 0.3 mmol/kg. Images were evaluated by measuring signal-to-noise (SNR) and contrast-to-noise (CNR) ratios and were judged for different image quality criteria by two blinded observers. RESULTS: In all patients both CE-MRA exams were of sufficient image quality to detect the AKA and ASA. No significant differences in SNR and CNR were observed between the two contrast agents. According to the observers, no significant differences in subjective image quality were found. CONCLUSIONS: Using both contrast agents it was possible to visualize the ultrasmall spinal cord arteries in all cases. The use of the 1.0-M contrast agent did not improve image quality of CE-MRA images of the blood supplying arteries of the spinal cord compared to the 0.5-M contrast agent.
Aged↗
Correction for heart rate variability improves coronary magnetic resonance angiography.
PURPOSE: To address degradation of coronary MR angiography (MRA) image quality due to heart rate variability (HRV)-associated variations in coronary artery position and motion. MATERIALS AND METHODS: Free-breathing navigator-gated and -corrected coronary MRA using subject-specific trigger delays and acquisition windows was combined with a real-time HRV correction algorithm, such as commonly used in left ventricular wall motion studies. Ten healthy adults underwent free-breathing navigator-gated and -corrected coronary MRA with and without HRV correction. Signal-to-noise (SNR), contrast-to-noise (CNR), vessel length, diameter, sharpness, and subjective image quality (on a five-point scale) were compared in a blinded fashion. RESULTS: Vessel sharpness improved significantly for both the left (LCA) and right (RCA) coronary artery systems (P = 0.016 and P = 0.015, respectively) with the use of HRV correction. Subjective image quality also improved significantly when HRV correction was used (P = 0.003). There were no significant differences with regard to SNR and CNR (P > 0.1). CONCLUSIONS: Preliminary results suggest that HRV correction improves objective and subjective image quality in coronary MRA. Continued studies in patients with known or suspected coronary artery disease are warranted to investigate the clinical impact of this technique.
Adolescent↗
Inherently self-calibrating non-Cartesian parallel imaging.
The use of self-calibrating techniques in parallel magnetic resonance imaging eliminates the need for coil sensitivity calibration scans and avoids potential mismatches between calibration scans and subsequent accelerated acquisitions (e.g., as a result of patient motion). Most examples of self-calibrating Cartesian parallel imaging techniques have required the use of modified k-space trajectories that are densely sampled at the center and more sparsely sampled in the periphery. However, spiral and radial trajectories offer inherent self-calibrating characteristics because of their densely sampled center. At no additional cost in acquisition time and with no modification in scanning protocols, in vivo coil sensitivity maps may be extracted from the densely sampled central region of k-space. This work demonstrates the feasibility of self-calibrated spiral and radial parallel imaging using a previously described iterative non-Cartesian sensitivity encoding algorithm.
Algorithms↗
Accuracy of semiautomated analysis of 3D contrast-enhanced magnetic resonance angiography for detection and quantification of aortoiliac stenoses.
OBJECTIVES: We sought to compare reproducibility and accuracy of semiautomated stenosis detection and quantification in 3D contrast-enhanced magnetic resonance angiography (CE-MRA) images with conventional evaluation of 3D CE-MRA in patients with peripheral arterial disease (PAD) by using intra-arterial digital subtraction angiography (IA-DSA) as standard of reference. METHODS: Twenty-five patients with PAD underwent CE-MRA and IA-DSA. Three blinded observers independently evaluated CE-MRA datasets for stenoses in the aortoiliac region using semiautomated computer analysis. Semiautomated measurements were compared with conventional measurements of stenosis on CE-MRA datasets, as measured by 3 other independent observers blinded to all other measurements. Interobserver agreement was quantified using kappa (kappa) and intraclass correlation coefficients (ICCs). Sensitivity and specificity were determined for both semiautomated and conventional measurements. RESULTS: Semiautomated measurements were successful in 124 of the 125 arterial segments. The sensitivity of semiautomated measurements was 89% for all observers; specificity varied between 87% and 89%. For conventional measurements of CE-MRA, sensitivity varied between 79% and 86%; specificity was between 86% and 96%. There was good interobserver agreement between all readers for semiautomated measurements (combined kappa for all 3 observers together = 0.78; ICC = 0.82), as well as for conventional measurements (combined kappa = 0.70; and ICC = 0.83). Differences between ICCs, combined kappa values, and accuracy of both measurements were not significant (all P > 0.05). CONCLUSION: Semiautomated analysis of aortoiliac 3D CE-MRA has the same high accuracy for detection and quantification of stenoses as conventional readings of CE-MRA.
Aged↗
Magnetic resonance angiography of abdominal and lower extremity vasculature.
Magnetic resonance angiography (MRA) has evolved over the past years from an experimental imaging modality to a technique that is now widely applied in clinical practice. This article reviews the fundamentals of the different magnetic resonance angiographic techniques and how they can be applied for abdominal and peripheral arterial imaging. Currently, contrast-enhanced magnetic resonance angiography (CE-MRA), whereby a luminogram is obtained during initial arterial passage of contrast material, is the most widely used technique. With current hardware and software, high-spatial resolution images of the abdominal aorta and proximal visceral branches can be obtained that are equivalent to intra-arterial digital subtraction angiography (IA-DSA). High-quality imaging of the renal arteries demands isotropic voxels and reformations orthogonal to the vessel axis for evaluation. Contrast-enhanced magnetic resonance angiography of the peripheral vascular tree is now a highly accurate technique and has replaced diagnostic intra-arterial digital subtraction angiography and duplex ultrasonography in many hospitals.
Abdomen↗
Peripheral arterial disease: comparison of color duplex US and contrast-enhanced MR angiography for diagnosis.
PURPOSE: To prospectively compare the diagnostic accuracies of color duplex ultrasonography (US) and contrast material-enhanced magnetic resonance (MR) angiography and to assess interobserver agreement regarding contrast-enhanced MR angiographic findings in patients suspected of having peripheral arterial disease (PAD). MATERIALS AND METHODS: The institutional review board approved the study, and all patients provided signed informed consent. Two hundred ninety-five patients referred for diagnostic and preinterventional work-up of PAD with duplex US also underwent gadolinium-enhanced MR angiography. Data sets were reviewed for presence or absence of 50% or greater luminal reduction, which indicated hemodynamically significant stenosis, and to determine interobserver agreement. At duplex US, a peak systolic velocity ratio of 2.5 or greater indicated significant stenosis. Primary outcome measures were differences between duplex US and contrast-enhanced MR angiography in sensitivity and specificity for detection of significant stenosis, as assessed with the McNemar test, and interobserver agreement between the two contrast-enhanced MR angiogram readings, expressed as quadratic weighted kappa values. Intraarterial digital subtraction angiography (DSA) was the reference standard. RESULTS: Two hundred forty-nine patients had at least one hemodynamically significant stenotic lesion at contrast-enhanced MR angiography, duplex US, or both examinations. One hundred fifty-two patients underwent intraarterial DSA. The quadratic weighted kappa for agreement regarding the presence of 50% or greater stenosis at contrast-enhanced MR angiography was 0.89 (95% confidence interval [CI]: 0.87, 0.91). Sensitivity of duplex US was 76% (95% CI: 69%, 82%); specificity, 93% (95% CI: 91%, 95%); and accuracy, 89%. Sensitivity and specificity of contrast-enhanced MR angiography were 84% (95% CI: 78%, 89%) and 97% (95% CI: 95%, 98%), respectively; accuracy was 94%. Sensitivity (P = .002) and specificity (P = .03) of contrast-enhanced MR angiography were significantly higher. CONCLUSION: Results of this prospective comparison between contrast-enhanced MR angiography and duplex US provide evidence that contrast-enhanced MR angiography is more sensitive and specific for diagnosis and preinterventional work-up of PAD.
Adult↗
Accuracy of computed tomographic angiography and magnetic resonance angiography for diagnosing renal artery stenosis.
BACKGROUND: Timely, accurate detection of renal artery stenosis is important because this disorder may be a potentially curable cause of hypertension and renal impairment. OBJECTIVE: To determine the validity of computed tomographic angiography (CTA) and magnetic resonance angiography (MRA) compared with digital subtraction angiography (DSA) for detection of renal artery stenosis. DESIGN: Prospective multicenter comparative study conducted from 1998 to 2001. Two panels of 3 observers judged CTA and MRA image data and were blinded to all other results. Digital subtraction angiography images were evaluated by consensus. SETTING: 3 large teaching hospitals and 3 university hospitals in the Netherlands. PATIENTS: 402 hypertensive patients with suspected renal artery stenosis were included. A group of 356 patients who underwent all 3 diagnostic tests was used for analysis. MEASUREMENTS: Reproducibility was assessed by calculating interobserver agreement. Diagnostic performance was evaluated in terms of sensitivity, specificity, and other diagnostic variables. Atherosclerotic stenoses of 50% or greater and fibromuscular dysplasia were considered clinically relevant. RESULTS: Twenty percent of patients who underwent all 3 tests had clinically relevant renal artery stenosis. Moderate interobserver agreement was found, with kappa values ranging from 0.59 to 0.64 for CTA and 0.40 to 0.51 for MRA. The combined sensitivity and specificity were 64% (95% CI, 55% to 73%) and 92% (CI, 90% to 95%) for CTA and 62% (CI, 54% to 71%) and 84% (CI, 81% to 87%) for MRA. LIMITATIONS: Eighteen percent of the patients were included nonconsecutively. Digital subtraction angiography may be an imperfect reference test. CONCLUSION: Computed tomographic angiography and MRA are not reproducible or sensitive enough to rule out renal artery stenosis in hypertensive patients. Therefore, DSA remains the diagnostic method of choice. *For a list of the other investigators and research coordinators who participated in RADISH, see the Appendix.
Adult↗
Spinal cord feeding arteries at MR angiography for thoracoscopic spinal surgery: feasibility study and implications for surgical approach.
PURPOSE: To prospectively investigate the feasibility of contrast material-enhanced magnetic resonance (MR) angiography for visualization of the spinal vasculature in patients referred for video-assisted thoracoscopic surgical treatment of a thoracic herniated disk and to prospectively assess the influence of preoperative imaging of the spinal vasculature on the choice of surgical approach. MATERIALS AND METHODS: Eight patients (three men and five women; mean age, 58 years; range, 42-83 years) with a thoracic herniated disk underwent contrast-enhanced MR angiography of the thoracoabdominal aorta and posterior branches. Imaging was performed with three-dimensional first-pass contrast-enhanced MR angiographic technique and a triple dose of gadolinium-based contrast agent. Images were analyzed by two observers in consensus to localize the Adamkiewicz artery (AKA) and its connections to the aorta and the anterior spinal artery (ASA). This information was used to determine any change in surgical approach. RESULTS: In all eight patients, the AKA, the ASA, and the connections with the aorta were identified. The AKA originated between T9 and L2 in all patients and derived from the left side of the aorta in 75% (six of eight) of the patients. In three patients in whom the AKA was observed on the left side, the surgical approach was changed to the right side to preserve spinal cord integrity. CONCLUSION: Preoperative imaging of the AKA is feasible with contrast-enhanced MR angiography. Contrast-enhanced MR angiography can be used to image the main feeding arteries of the spinal cord in patients undergoing thoracoscopic spinal surgery, and results can be used to change the side of surgical approach.
Adult↗
Use of a three-station phased array coil to improve peripheral contrast-enhanced magnetic resonance angiography.
PURPOSE: To explore the imaging capabilities of a new commercially available, three-station, 129-cm long, 12-element phased array coil for contrast-enhanced magnetic resonance angiography (CE-MRA) in patients with symptomatic peripheral arterial occlusive disease. MATERIALS AND METHODS: Nineteen patients, referred for peripheral CE-MRA, were evaluated using the new three-station coil. For each station four coil elements (two anterior and two posterior to the patient) were used. The expected improvements in signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were used to improve spatial resolution and increase anatomic coverage for the distal two stations compared to our previous protocol. Images obtained in the 19 patients imaged with the new coil were compared to those of the last 19 patients scanned without the use of the new coil. Differences in image quality before vs. after the availability of the new coil were compared in terms of SNR and CNR, subjective interpretability score (SIS), degree of venous enhancement, and anatomic coverage. Images were interpreted by two experienced observers, blinded for imaging technique and each other's results. RESULTS: Use of the coil enabled acquisition of high resolution peripheral vasculature images in all cases and allowed for substantially smaller voxel sizes (thighs: 5.3 vs. 8.4 mm(3) [-37%]; legs: 1.8 vs. 8.0 mm3 [-78%]) and much shorter acquisition durations in the aortoiliac and thigh stations (aortoiliac: 16 vs. 27 seconds [-41%]; thighs: 11 vs. 23 seconds [-52%]). Acquisition duration in the leg station was prolonged (68 vs. 29 seconds [+134%]). SNR and CNR were significantly higher only in the aortoiliac station using the three-station coil (both: P < 0.001). There were no significant differences in SIS for the aortoiliac and thigh stations (aortoiliac station: observer 1: P = 0.16, observer 2: P = 0.19; thigh station: both observers: P = 0.27). Images acquired with the new coil had significantly higher SIS for the leg station (both observers: P = 0.004). There were no significant differences in venous enhancement between the two protocols for any of the stations (all P > 0.11). In 12/12 (100%) requested cases the entire pedal arch was depicted using the new coil, whereas this was not possible with the old protocol. CONCLUSION: The new three-station dedicated peripheral vascular coil allows for much higher resolution imaging in the thigh and leg stations with greater anatomic coverage and substantially improves peripheral MRA quality of the lower leg vasculature.
Adult↗
Comparison of contrast-enhanced magnetic resonance angiography and digital subtraction angiography in patients with chronic critical ischemia and tissue loss.
RATIONALE AND OBJECTIVES: To compare the ability of intra-arterial digital subtraction angiography (IA-DSA) and total runoff contrast-enhanced magnetic resonance angiography (CE-MRA) to demonstrate peripheral arterial anatomy, specifically in patients with chronic critical ischemia and tissue loss. MATERIALS AND METHODS: Twenty-three consecutive patients with chronic critical ischemia and tissue loss underwent CE-MRA and IA-DSA within 2 days. Two teams, consisting of an interventional radiologist and vascular surgeon who were blinded to each other's results, determined the number of named arteries (21 segments) and the presence of >/=50% stenosis or occlusion. RESULTS: Compared with IA-DSA, both teams detected significantly more arterial segments with CE-MRA, both above and below the knee (team 1: above knee 7.0 versus 5.2, P = 0.002, and below knee 8.5 versus 5.4, P < 0.001; team 2: above knee 7.1 versus 5.4, P = 0.004, and below knee 8.3 versus 5.9, P < 0.001). Interobserver agreement between the 2 teams with regard to presence of arteries and the presence of stenoses and/or occlusions yielded kappa values of 0.76 (95% confidence interval 0.71-0.81) for IA-DSA and 0.73 (95% confidence interval 0.66-0.80) for CE-MRA. Treatment was changed based on the CE-MRA findings in 8/23 (35%) patients. CONCLUSIONS: In the present study CE-MRA detected more patent arteries than IA-DSA in patients with chronic critical ischemia and tissue loss. CE-MRA can modify the choice of therapeutic strategy in these patients.
Aged↗
Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography.
The purpose of this study was to compare moving-table three-dimensional contrast-enhanced magnetic resonance angiography (CE MRA), using 1.0-mol gadobutrol, with intra-arterial digital subtraction angiography (i.a. DSA) for evaluation of pelvic and peripheral arteries in patients with peripheral arterial occlusive disease. A total of 203 patients were examined in a prospective, multi-centre study at 1.0/1.5 T. Ten vessel segments of one leg were evaluated on-site and by three independent blinded reviewers off-site. One hundred eighty-two patients were evaluable in blinded reading. For pelvis and thigh, there was statistically significant diagnostic agreement between CE MRA and i.a. DSA on-site (94%) and off-site (86-88%). Overall, for detection of clinically significant stenoses, 93% sensitivity and 90% specificity were achieved in on-site evaluation, with 71-76 and 87-93% off-site; for detection of occlusion, sensitivity and specificity on-site were 91 and 97%, with 75-82 and 94-98% off-site. Evaluation was more sensitive on-site than off-site for detection of stenoses and occlusion, whereas specificity was similar. The CE MRA with 1.0-mol gadobutrol gave results comparable to those of i.a. DSA for the larger arteries of pelvis and thigh. Results for calf arteries were compromised by spatial resolution and technical limitations.
Angiography, Digital Subtraction↗
Multicenter phase-II trial of safety and efficacy of NC100150 for steady-state contrast-enhanced peripheral magnetic resonance angiography.
The aim of this study was to test the safety and efficacy of NC100150 injection for steady-state contrast-enhanced peripheral MR angiography in a multicentre phase-II trial. Thirty-three patients underwent steady-state NC100150 enhanced MR angiography (5 mg Fe/kg body weight) of the aortoiliac and femoropopliteal arteries. Safety assessment consisted of pre- and post-injection (2, 24 and 72 h) monitoring of vital signs, physical examination as well as laboratory and electrocardiographic parameters. To determine sensitivity and specificity for detection of haemodynamically significant stenoses (HSS; >50% reduction of luminal diameter) MR angiograms were compared with intra-arterial digital subtraction angiography (IA DSA), which was considered the standard of reference. In 33 patients a mean of 12.8 ml NC100150 was injected. Eleven patients reported 13 mild and 2 moderate adverse events. Five mild and one moderate adverse event were considered due to NC100150 injection. There were no significant changes in vital signs, laboratory or electrocardiographic parameters. Sensitivity and specificity (in percent) for detection of HSS were 87 and 64, 56 and 76, and 75 and 84, for iliac, femoral and popliteal arteries, respectively. NC100150 high-resolution steady-state MR angiography can be performed safely and is feasible for the detection of peripheral arterial HSS, but is as yet not a clinically useful alternative to conventional gadolinium-enhanced MR angiography.
Angiography, Digital Subtraction↗