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Biomedical subjects

Timothy P Rohrig

Publications and source records attributed to Timothy P Rohrig.

4 recordsLinked to original sources
PubMed2003

The analysis and distribution of mescaline in postmortem tissues.

Mescaline (3,4,5-trimethoxyphenethylamine) is a hallucinogenic alkaloid found in the peyote cactus. This report documents mescaline distribution in a death caused by multiple gunshot wounds. Mescaline was extracted with a butyl chloride liquid-liquid method and identified by mass spectrometry. Quantitative analysis was performed by gas chromatography using a nitrogen-phosphorus detector. Concentrations of the drug were 2.95 mg/L, 2.36 mg/L, 8.2 mg/kg, and 2.2 mg/kg in blood, vitreous, liver, and brain, respectively.

Forensic Medicine↗
PubMed2003

The determination of morphine in urine and oral fluid following ingestion of poppy seeds.

In workplace drug-testing programs, the use of heroin, morphine, and codeine is currently determined by the analysis of urine specimens. It has been shown that ingestion of poppy seeds can cause a positive test result for morphine. In an attempt to differentiate positive results caused by poppy seed ingestion from those caused by heroin or morphine abuse, the screening cutoff concentration for urine opiates in the federal workplace drug-testing program was raised to 2000 ng/mL from 300 ng/mL. Currently, oral fluid is under consideration as a possible alternative to urine for drug testing. The suggested cutoff for oral fluid morphine is 40 ng/mL; however, the effect of poppy seed ingestion on morphine concentrations in this specimen type has not been widely investigated. Volunteers at two separate sites ingested commercially available poppy seeds and/or poppy seed bagels. Oral fluid and urine samples were collected at both sites. Oral fluid samples were collected for 24 h; urine was collected for 2 days. The samples were analyzed for the presence of codeine and morphine using gas chromatography-mass spectrometry. Morphine concentrations greater than the suggested cutoff concentrations were detected in oral fluid up to 1 h and in urine for up to 8 h. This study has demonstrated that a positive result for morphine in oral fluid may be due to the ingestion of poppy seeds.

Adult↗
PubMedDate not supplied

A sertraline-intoxicated driver.

Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is chemically unrelated to other SSRIs, tricyclic antidepressants, and other currently available antidepressant medications. This report documents a case of driving under the influence of sertraline. The subject was involved in a motor vehicle accident. Upon contact by law enforcement, the subject was confused and could neither stand nor walk. The officer noted mumbled speech, droopy eyes, and that the subject seemed sleepy. No alcohol was present in the vehicle, and no odor of alcohol was detected on the subject's breath. The subject was determined to be under the influence of some intoxicating substance. Toxicological analysis revealed only the presence of sertraline. Sertraline was extracted from the blood sample utilizing solid-phase extraction and identified and quantitated by gas chromatography-mass spectrometry. The blood sertraline concentration was determined to be 1285 microg/L.

Accidents, Traffic↗