Biomedical subjects

Tingchu Wang

Publications and source records attributed to Tingchu Wang.

5 recordsLinked to original sources

PubMed2006

[Arousal response in child patients in obstructive sleep apnea].

OBJECTIVE: To analyze arousal response of Polysomnography (PSG) in children with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHOD: Fourty-eight children with sleep disorder were studied with 32 guide Polysomnography and analyzed by Polysmith. Sleep structure and arousals of preschool-aged and school-aged children with OSAHS were compared with those of primary snore patients. RESULT: The mean value of AHI of preschool aged children with OSAHS was (10.6+/-8.9) h, of AI was (4.0+/-7.1) h, of HI was (6.6+/-4.6) h; The sleep structure between OSAHS group and primary snore group was not significant (P > 0.05). The mean value of ArI with AHI was (8.2+/-5.9) h, of ArI with LM was (19.6+/-5.8) h, whole ArI was 49.3+/-20.4 in preschool-aged children with OSAHS; The mean value of ArI with AHI was (7.6+/-6.3) h, of ArI with LM was (14.3+/-7.6) h, whole ArI was 49.9+/-14.9 in school-aged children with OSAHS. Those of OSAHS children were higher than that of primary snore patients (P < 0.05). CONCLUSION: Although OSAHS in children is characterized by a restless sleep, the structure is perfect and mildly affected by OSAHS. The ArI with AHI, with LM and the whole ArI in OSAHS children is higher than those of primary snore patients.

Arousal↗

PubMed2005

[Polysomnography analysis in children].

OBJECTIVE: To analyze the characteristics of Polysomnography (PSG) in children with obstructive sleep apnea-hypopnea syndrome(OSAHS). METHOD: Forty-five children with sleep breathing disorder were studied with 32 guide PSG and analyzed by Polysmith. PSG results of OSAHS children were compared with primary snore group. RESULT: The mean age of OSAHS children was(7.3 +/- 3.8) years and the mean body weight was (40.1 +/- 19.7) kg. The mean value of NREM stage 1, stage 2, stage 3+4 and REM stage was(21.4 +/- 13.2)%, (43.1 +/- 13.7)%, (26.1 +/- 14.0) % and (9.4 +/- 6.0) % respectively. The sleep structure between OSAHS group and primary snore group was not significant (P > 0.05). The mean value of AHI of OSAHS children was(12.8 +/- 8.1) h. AI was (6.7 +/-6.6)h, HI was(6.1 +/- 5.1)h. CONCLUSION: The sleep structure of children is prefect and mild effected by OSAHS.

Adolescent↗

PubMed2005

[Research about sleep structure of OSAHS].

OBJECTIVE: Research the sleep structure of the OSAHS and snores, explore the reason that patients feel drowsy in daytime. METHOD: Monitor the sleep of 46 OSAHS, 16 snores and 20 normal control, calculate the percent of stages of NREM and REM, count the RDI, AI, HI, total MI, MI associated with leg movement, MI associated with RDI, MI associated with snore, spontaneous MI. RESULT: OSAHS has sleep structure disturbance obviously. The light sleep (stage I) increase obviously, but deep one decrease (stage II + V) obviously. The sleep structure is insufficient. The patients are deprived of a number of the REM sleep. The waking time is longer than normal control group. During the light sleep, the microarousal that is associated with both apnea and leg movement increase obviously. CONCLUSION: During the sleep, OSAHS has obvious sleep deprivation, frequent arousal, disturbance sleep structure and blood desaturation, etc. These resulted in disturbances of brain metabolize. This is the reason that patients feel drowsy, feeble decline, etc.

Adult↗

PubMed2005

[Application of hyoid suspension in obstructive sleep apnea-hypopnea syndrome].

OBJECTIVE: To treat OSAHS with hyoid suspension and evaluate treating effect. METHOD: Twenty-eight patients of median, severe OSAHS were treat with functional endoscopic sinus surgery, UPPP+ hyoid suspension. The length of follow up was 6 months. PSG was used for diagnosis and pre up, post up evaluation. RESULT: AHI of 28 patients reduced from (52.8 +/- 21.4)h to (15.2 +/- 13.3)h (P < 0.05). Effective rate is 85.7%. CONCLUSION: Hyoid suspension is an effective method of safety, simplicity, few complications.

Adult↗

PubMed2004

[Study on the polymorphism of angiotensin converting enzyme genes and serum angiotensin II level in patients with obstructive sleep apnea hypopnea syndrome accompanied hypertension].

OBJECTIVE: To explore the relationship of the ACE gene insertion/deletion (I/D) polymorphism and the rennin-angiotensin system in the pathogenesis of hypertension in OSAHS. METHOD: Gene DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). The distribution of.the ACE gene I/D allele and genotypes were analyzed in 30 OSAHS with hypertension patients, 30 normotensive OSAHS patients and 30 healthy control group without cardiovascular diseases. The serum level of angiotensin II were also measured in all subjects by angiotensin II enzyme immunoassay kit. RESULT: The frequency of II genotype and I allele were significantly higher in the OSAHS accompanied hypertension patients than those in the healthy controls (chi2=9.88, chi2=16.13, P<0.01, respectively) and in the normotensive OSAHS patients (chi2=5.67, P<0.05, chi2=8.61, P<0.01). The frequency of II genotype and I allele had no significantly different between the normotensive OSAHS patients and the healthy controls (P>0.05). The serum level of angiotensin II was significantly higher in both OSAHS patients with and without hypertension than that in the healthy control (t=3.66, t=3.23, respectively P<0.01). Whereas the serum level of angiotensin II have no significantly different in the OSAHS patients with and without hypertension (P>0.05). CONCLUSION: These results indicate that the higher frequency of ACE gene I allele and genotype are closely associated with OSAHS patients accompanied hypertension. It is one of the important risk factors for the genesis of hypertension in OSAHS. The activity of rennin-angiotension system is higher in the OSAHS may have contribute to OSAHS-induced hypertension.

Adult↗