Biomedical subjects

Tingting Lin

Publications and source records attributed to Tingting Lin.

3 recordsLinked to original sources

PubMed2006

ABC transporters, neural stem cells and neurogenesis--a different perspective.

Stem cells intrigue. They have the ability to divide exponentially, recreate the stem cell compartment, as well as create differentiated cells to generate tissues. Therefore, they should be natural candidates to provide a renewable source of cells for transplantation applied in regenerative medicine. Stem cells have the capacity to generate specific tissues or even whole organs like the blood, heart, or bones. A subgroup of stem cells, the neural stem cells (NSCs), is characterized as a self-renewing population that generates neurons and glia of the developing brain. They can be isolated, genetically manipulated and differentiated in vitro and reintroduced into a developing, adult or a pathologically altered central nervous system. NSCs have been considered for use in cell replacement therapies in various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Characterization of genes with tightly controlled expression patterns during differentiation represents an approach to understanding the regulation of stem cell commitment. The regulation of stem cell biology by the ATP-binding cassette (ABC) transporters has emerged as an important new field of investigation. As a major focus of stem cell research is in the manipulation of cells to enable differentiation into a targeted cell population; in this review, we discuss recent literatures on ABC transporters and stem cells, and propose an integrated view on the role of the ABC transporters, especially ABCA2, ABCA3, ABCB1 and ABCG2, in NSCs' proliferation, differentiation and regulation, along with comparisons to that in hematopoietic and other stem cells.

ATP Binding Cassette Transporter, Subfamily B↗

PubMed2005

A DFT study of the amination of fullerenes and carbon nanotubes: reactivity and curvature.

The first principles density functional theory (DFT) approach (GGA-PW91/DNP) was used to study the addition reaction of methylamine to fullerenes C(50) and C(60) or single-walled carbon nanotubes (SWNTs) (5,5) and (10,0). To understand the relationship between reactivity and curvature, various addition sites have been investigated for comparisons. The DFT calculation results showed that the reaction energy of the addition of methylamine onto C(60) or the closed caps of (5,5) and (10,0) is rather low. Moreover, the reaction at a few sites even appears exothermic. However, the reaction on the perfect sidewall of the nanotubes is always endothermic, and the reaction energy is much higher than that on the caps. The energetically preferable addition sites are the carbon atoms located at the vertexes formed with five-, five-, six-membered rings on C(50) or five-, five-, seven-membered rings on defects of nanotubes. The systematic theoretical study revealed that the pyramidalization and pi-orbital misalignment could result in an increased reactivity of these pentagon-pentagon fusion sites. The reactivity depends on the pyramidalization angle, which is a quantitative measurement of the local curvature and strain of the reaction center.

Journal Article↗

PubMed2004

Highly efficient luminescent organic clusters with quantum dot-like properties.

Organic clusters with uniform structure and size have been synthesized and studied. The quantum confinements on organic arms [chains shorter than exciton Bohr radii (aB)] have been confirmed by the discrete energy levels from PLE, narrow PL lines, size effect from UV, and spherical shape from TEM, as well as Raman peaks red-shifting and broadening. The results indicate the materials have QD-like properties.

Journal Article↗