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Biomedical subjects

Todd Cook

Publications and source records attributed to Todd Cook.

9 recordsLinked to original sources
PubMed2006

Sclerosing therapy as first line treatment for low flow vascular lesions of the orbit.

PURPOSE: To evaluate the outcome of sodium morrhuate 5% injections in patients with low flow vascular lesions, which consist of orbital lymphangiomas, and in one patient with intraosseous cavernous hemangioma. DESIGN: Prospective, interventional consecutive case series. METHODS: Intralesional sodium morrhuate 5% was injected under direct visualization or under radiographic guidance to six patients with orbital lymphangiomas and one patient with intraosseous cavernous hemangioma. Comprehensive eye examination and follow-up imaging studies were performed. main outcome measures: Lesion size was evaluated by orbital imaging and clinical examination, visual acuity, exophthalmos, and posttreatment complications. RESULTS: Seven patients (four female, three male; average age, 33 years) were included. Six patients were diagnosed with orbital lymphangioma, and one patient was diagnosed with intraosseous cavernous hemangioma. Patients received an average of 2.6+/-2 intralesional injections of sodium morrhuate, with a range of one to six injections and a mean volume of 0.9+/-0.8 ml (range, 0.2 to 2.1 ml). Lesions showed a decrease in size an average of 50% (33%) and ranged from minimal (10%) to near total resolution (85%). Visual acuity and intraocular pressure remained unchanged; exophthalmos decreased an average of 1.5+/-1.8 mm. Complications included one case of orbital hemorrhage that resolved spontaneously and transient keratopathy in all patients with anterior orbital lesions. CONCLUSION: Intralesional sclerosing therapy with sodium morrhuate 5% is effective in tumor debulking in patients with orbital lymphangioma and is not associated with vision-threatening complications. It may be a better alternative to surgery for low flow orbital tumors, which includes lymphangioma.

Adolescent↗
PubMed2004

Regulation of carbohydrate metabolism by the farnesoid X receptor.

The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that functions as the bile acid receptor. In addition to the critical role FXR plays in bile acid metabolism and transport, it regulates a variety of genes important in lipoprotein metabolism. We demonstrate that FXR also plays a role in carbohydrate metabolism via regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression. Treatment of either H4IIE or MH1C1 rat hepatoma cell lines as well as primary rat or human hepatocytes with FXR agonists led to stimulation of PEPCK mRNA expression to levels comparable to those obtained with glucocorticoid receptor agonists. We examined the physiological significance of FXR agonist-induced enhancement of PEPCK expression in primary rat hepatocytes. In addition to inducing PEPCK expression in primary hepatocytes, FXR agonists stimulated glucose output to levels comparable to those observed with a glucocorticoid receptor agonist. Consistent with these observations, treatment of C57BL6 mice with GW4064 significantly increased hepatic PEPCK expression. Activation of FXR initiated a cascade involving induction of peroxisome proliferator-activated receptor alpha and TRB3 expression that is consistent with stimulation of PEPCK gene expression via interference with a pathway that may involve Akt-dependent phosphorylation of Forkhead/winged helix transcription factor (FOXO1). The FXR-peroxisome proliferator-activated receptor alpha-TRB3 pathway was conserved in rat hepatoma cell lines, mice, as well as primary human hepatocytes. Thus, in addition to its role in the regulation of lipid metabolism, FXR regulates carbohydrate metabolism.

Animals↗
PubMed2004

Facial recontouring with autogenous fat.

Facial fat deflation represents a significant component of facial aging. We discuss and detail preoperative patient selection, fat transfer technique, and potential pitfalls. Fat transfer can reliably improve facial fat deflation and improve facial appearance in the long-term.

Adipose Tissue↗
PubMed2003

The horizontal dynamic of the medial and lateral canthus.

PURPOSE: To identify and quantify the horizontal dynamic movement of the medial and lateral canthus in subjects without previous eyelid surgery. METHODS: Prospective, experimental study. RESULTS: Seventy-two eyes in 36 normal subjects were studied. Frontal view lateral canthal movement with abduction of the globe averaged -0.4 mm (negative numbers mean the canthus moves in the opposite direction of the globe), with a range of -3.8 to 2.1. Profile view lateral canthal movement with abduction of the globe averaged 1.6 mm, with a range of -2.2 to 4.7 mm. Frontal view lateral canthal movement with adduction of the globe averaged -0.3 mm, with a range of -3.7 to 3.9 mm. Profile view lateral canthal movement with adduction of the globe averaged 0.5 mm, with a range of -2.4 to 3.9 mm. Frontal view medial canthal movement with abduction of the globe averaged -0.4 mm, with a range of -3.9 to 1.5 mm. Frontal view medial canthal movement with adduction of the globe averaged 0.1 mm, with a range of -5.2 to 4.6 mm. Intrasubject variation was observed for all measurements. CONCLUSIONS: The medial canthus and the lateral canthus are dynamic structures that move with horizontal eye movements in patients who have not undergone canthoplasty. The measured movement of the lateral canthus differed, based on the position from which the measurements were made, and was not always in the direction of the globe. The movement of the lateral canthus and the medial canthus differed on the right and left sides of the same subject.

Adolescent↗
PubMed2003

Lumps and bumps: late postsurgical inflammatory and infectious lesions.

Late postsurgical infectious or inflammatory complications after facial surgery present a difficult challenge. These complications occur at least 2 weeks after surgical procedures and are often attributable to unique causes, in contrast to complications within the first postoperative week. The most worrisome complications in this period are caused by mycobacterial infections, because these infections can be severe and require a protracted treatment course. A high degree of suspicion is required early in presentation because these lesions can be subtle and similar to other infectious or inflammatory lesions. The authors discuss the clinical manifestations and diagnostic and treatment rationale for late postoperative infectious and inflammatory lesions. The authors also demonstrate and compare the clinical manifestations of mycobacterial infections, bacterial infections, and sterile inflammatory reactions. In addition, the treatment rationale for mycobacterial infections is reviewed. Late postoperative infections caused by mycobacteria are reported with increasing frequency in the cosmetic literature. These cases illustrate diverse challenges in the identification and treatment of late postoperative lesions.

Aged↗
PubMed2002

Ocular and periocular injuries from orbital fractures.

BACKGROUND: Orbital fractures are associated with ocular and periocular injuries. The role of the ophthalmologist in the evaluation and management of facial trauma, including orbital fractures, has not been clearly defined. The purpose of this study is to identify and characterize ocular and periocular injuries associated with orbital fractures to define the role of the ophthalmologist in the management of facial trauma. STUDY DESIGN: Retrospective case review. RESULTS: Three hundred sixty-five patients with orbital fractures who were evaluated by an ophthalmologist as part of their initial trauma evaluation were studied. The majority of the patients with orbital fractures (74%) did not have associated ocular or periocular injuries. Twenty-three of 104 (22%) ocular injuries in 23 of 95 (24%) patients required immediate intervention by an ophthalmologist. CONCLUSIONS: Facial trauma and orbital fractures are associated with significant ocular and periocular injuries, the minority of which require immediate evaluation and treatment by an ophthalmologist. These results differ from those previously reported.

Eye Injuries↗