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Todd Milbrandt

Publications and source records attributed to Todd Milbrandt.

2 recordsLinked to original sources

Treatment of posttraumatic adhesive capsulitis of the ankle: a case series.

BACKGROUND: Adhesive capsulitis of the ankle is a challenging diagnostic and therapeutic problem. Limited information concerning diagnosis and treatment is available in the musculoskeletal literature. METHODS: This study retrospectively reviewed a series of patients treated with corticosteroid injections or arthroscopic debridement of posttraumatic adhesive capsulitis of the ankle. The Foot Function Index was used to assess the final treatment outcomes. RESULTS: Forty-one patients with chronic posttraumatic ankle pain were identified. Five were confirmed to have posttraumatic adhesive capsulitis by arthrogram. Four of the five patients failed to respond to steroid injections and three had arthroscopic surgery. Foot Function Index scores indicated that two of these patients treated with arthroscopic debridement had improved function. CONCLUSIONS: Results of small series and information from the literature suggest that intra-articular injection of corticosteroid followed by arthroscopic synovectomy and scar resection can be effective as treatment for posttraumatic adhesive capsulitis of the ankle.

Adrenal Cortex Hormones↗

Tracing transduced cells in osteochondral defects.

In this study the authors explored the feasibility of using transduced cells for gene therapy to induce healing of osteochondral defects. Both a mouse mesenchymal cell line and mixed rabbit adherent stromal cells were transduced with either liposomal transfection or retroviral transduction using a traceable gene. Transduction efficiency was more than 95% with the retroviral construct and expression was maintained for over 6 months of passage. The liposomal transfection led to a transient expression with an efficiency of 50%. The expression of osteochondral genes was diminished but preserved after transduction in vitro. Transduced rabbit cells were transplanted into osteochondral defects in rabbit femoral condyles. Cells transplanted in vivo could be detected for 4 weeks in the repair tissue. The authors' data demonstrate that mesenchymal cells from bone marrow, stably transduced with a traceable gene product, retain the bone and cartilage phenotype and can be followed in vivo after transplantation into cartilage defects.

Animals↗