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Biomedical subjects

Tokio Nakada

Publications and source records attributed to Tokio Nakada.

8 recordsLinked to original sources
PubMed2005

Eyeglass frame allergic contact dermatitis: does tacrolimus prevent recurrences?

A 35-year-old man developed well-demarcated, oedematous and erosive erythematous lesions on the nasal bridge and retroauricular regions bilaterally. His eyeglass frame was repaired by an optician 2 weeks prior to symptom onset. Patch testing revealed a positive reaction to scrapings of nose pads and temples of the frame in petrolatum. Because the patient did not take our exhortation to change eyeglass frames, we advised him to cover their nose pads and temples with vinyl tape to prevent direct skin contact. Although topical corticosteroid therapy produced clinical resolution temporally, recurrences were not prevented. After starting tacrolimus ointment therapy, recurrence has not occurred for 9 months. Tacrolimus may be effective for allergic contact dermatitis patients who cannot avoid repeated allergen exposure, as it may not only reduce inflammation but inhibit recurrences.

Adult↗
PubMed2005

Autopsy case of CD4/CD8 cutaneous T-cell lymphoma presenting disseminated pagetoid reticulosis with aggressive granulomatous invasion to the lungs and pancreas.

Pagetoid reticulosis is a rare cutaneous T-cell lymphoma with striking epidermotropism similar to that present in Paget's disease. There are two forms of pagetoid reticulosis: localized and disseminated. Reported herein is an autopsy case of disseminated pagetoid reticulosis with CD4(-)/CD8(-) phenotype T cells and massive invasion of the lungs and pancreas. The abnormal cells in the epidermis expressed a protein derived from a rearranged T-cell receptor beta gene, and this feature was used to confirm the monoclonality of these cells by polymerase chain reaction. At present, the World Health Organization (WHO) classification system considers pagetoid reticulosis to be an indolent form of primary cutaneous T-cell lymphoma and a variant of mycosis fungoides/Sezary syndrome with prominent epidermotropism. Some differences have been observed between pagetoid reticulosis and mycosis fungoides in terms of clinical course, tumor cell phenotype, and genetic findings; and these differences are highlighted in the present case. The relation between disseminated pagetoid reticulosis, CD4(-)/CD8(-) cutaneous T-cell lymphoma, and gammadelta T-cell lymphoma, including whether pagetoid reticulosis is a variant of mycosis fungoides, remains unclear.

Autopsy↗
PubMed2004

Annular lichen planus.

BACKGROUND: Annular lichen planus is a clinical variant of lichen planus, and its characteristic lesions are annular plaques consisting of a narrow rim of activity and a depressed center. OBJECTIVE: This article presents two cases of annular lichen planus, a 39-year-old woman and a 45-year-old woman. METHODS AND RESULTS: In both cases, lesions developed mainly on the femoral regions. Histopathological specimens from the margin of the lesion demonstrated liquefaction degeneration of the epidermis and band-like infiltrate of lymphocytes in the upper dermis, whereas there was very mild infiltrate in the upper dermis from the center. In the center, elastic fibers were more fragmented and less numerous than in the margin. Although topical corticosteroid tape was effective for one case, new lesions developed several times over two years in the other. CONCLUSION: Our findings suggest that this clinical behavior is from elastolysis as a result of inflammation.

Adult↗
PubMed2003

Gold allergy in Japan.

In Japan, gold dermatitis due to ear piercing increased in the early 1990s, but has subsequently become rare. To evaluate this clinical finding and to determine the frequency of gold allergy in Japan, we analysed the results of patch testing with 0.2% gold chloride from 1990 to 2001. 653 patients were tested from March 1990 to December 2001. 55 patients showed a positive reaction to gold (8.4%). Significantly more women (10.2%) than men (0.8%) reacted (P < 0.005), but there was no significant difference between positive rates from 1990 to 1995 (9.2%) and from 1996 to 2001 (7.2%). Our data suggest that patients with gold allergy did not decrease in number, despite a decreased number of patients showing clinically overt gold dermatitis. Thus, gold allergy has changed from being clinically overt to becoming occult in Japan.

Adolescent↗
PubMed2002

Disseminated pagetoid reticulosis (Ketron-Goodman disease): six-year follow-up.

Pagetoid reticulosis consists of 2 types: Woringer-Kolopp and Ketron-Goodman disease (K-G). Compared with the former, K-G may have disseminated lesions and a guarded prognosis. We encountered a case of K-G in a 67-year-old man with disseminated plaques on the neck, the trunk, and both extremities. Histologic specimens demonstrated medium- to large-sized, atypical cells infiltrating in the lower epidermis. The phenotype (CD3(+), CD4(-), CD8(-), CD45RO(-), CD45RA(+)) and ultrastructural findings suggest that these cells were immature T cells. Although PUVA was initially effective, new plaques in which atypical cells are still present histologically, have appeared through a 6-year follow-up. Literature review revealed the high rate of recurrence. These findings suggest that K-G is an epidermotropic or immature T-cell variant of mycosis fungoides. In patients with K-G, therefore, long-term observation is necessary: Disappearance of cutaneous lesions may not mean cure.

Aged↗