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Biomedical subjects

Tom Anderson

Publications and source records attributed to Tom Anderson.

8 recordsLinked to original sources

Error analysis of ultrasonic tissue doppler velocity estimation techniques for quantification of velocity and strain.

Recent work in the field of Doppler tissue imaging has focused mainly on the quantification of results involving the use of techniques of strain and strain-rate imaging. These results are based on measuring a velocity gradient between two points, a known distance apart, in the region-of-interest. Although many recent publications have demonstrated the potential of this technique in clinical terms, the method still suffers from low repeatability. The work presented here demonstrates, through the use of a rotating phantom arrangement and a custom developed single element ultrasound system, that this is a consequence of the fundamental accuracy of the technique used to estimate the original velocities. Results are presented comparing the performance of the conventional Kasai autocorrelation velocity estimator with those obtained using time domain cross-correlation and the complex cross-correlation model based estimator. The results demonstrate that the complex cross-correlation model based technique is able to offer lower standard deviations of the velocity gradient estimations compared with the Kasai algorithm.

Algorithms↗

B-mode compound imaging in mice.

Cross-sectional B-mode images were obtained from a dead mouse for a 360 degrees scan around the mouse using a 12-MHz linear array. For each cross-section, a set of aligned images was obtained after rotation about the isocenter, which were added to produce a single compound image. The compound images demonstrated a substantial improvement over single B-mode images, with uniform image quality, low noise and improved visualization of structures. This technique may be of interest in forming the basis for a new 3-D in vivo technique in the abdomen and pelvic regions, providing high-quality ultrasound images that are not dependent on operator skill. A further development worth pursuing for improved spatial resolution is reconstruction-based tomography.

Animals↗

The use of the fractional Fourier transform with coded excitation in ultrasound imaging.

Medical ultrasound systems are limited by a tradeoff between axial resolution and the maximum imaging depth which may be achieved. The technique of coded excitation has been used extensively in the field of RADAR and SONAR for some time, but has only relatively recently been exploited in the area of medical ultrasound. This technique is attractive because allows the relationship between the pulse length and the maximum achievable spatial resolution to be changed. The work presented here explores the possibility of using the fractional Fourier transform as an effective means for the processing of signals received after the transmission of linear frequency modulated chirps. Results are presented which demonstrate that this technique is able to offer spatial resolutions similar to those obtained with a single cycle duration signal.

Algorithms↗

Influence of scanning frequency and ultrasonic contrast agent on reproducibility of left ventricular measurements in the mouse.

BACKGROUND: Mice are now widely used as models of cardiovascular disease. Their small size and fast heart rates are technically challenging to echocardiography. This study examined the influence of different scanning frequencies and ultrasonic contrast agent (UCA) on the accuracy and reproducibility of measurements of left ventricular (LV) structure and function. METHODS: Normal mouse hearts (C57BL6) were imaged at 3 different scanning frequencies before and after intravenous injection of the UCA, Optison. Coronary artery ligation mice and sham-operated controls were scanned at 10-22 MHz with and without UCA. RESULTS: Scanning frequency had no significant effect on intraobserver or interobserver variation of LV measurements in normal mice under baseline conditions. Use of UCA significantly reduced estimated ejection fraction at 10-22 MHz compared with baseline (baseline 50.8 +/- 7.6% vs UCA 39.7 +/- 7.6%; P = .03) and significantly increased values for LV cavity dimensions (eg, LV area diastole 20.74 +/- 1.20 vs 23.23 +/- 0.98 mm 2 ; P = .002). UCA significantly reduced intraobserver and interobserver variation in LV ejection fraction. CONCLUSIONS: Scanning frequency had no significant effect on reproducibility of LV measurements in the mouse but UCA significantly reduced interobserver variation. Use of UCA could reduce the number of mice required in any given experiment to observe a statistically significant change in LV function.

Albumins↗

Laser Doppler anemometry measurements of the shear stresses on ultrasonic contrast agent microbubbles attached to agar.

Ultrasonic contrast agents are currently being developed to target and bind to specific areas of interest such as atheromous plaque. A microbubble has been developed in-house which can be targeted to attach to specific cell-lines. To assess the feasibility of using the microbubble in vivo, the shear stresses which the bound microbubbles can withstand need to be known. A flow chamber was developed for use with intravascular ultrasound (IVUS) and laser Doppler anemometry (LDA). Biotin was incorporated into the microbubble shells and streptavidin was used to attach them to agar. IVUS at 40 MHz was then used to image the attached microbubbles under steady flow at a range of flow rates from 75 to 480 mL min(-1) through a flow area of 9 mm(2). LDA was employed to find high resolution velocity profiles of the flow in the chamber at a selection of these flow rates and the shear stresses on the bubbles were calculated. The bubbles were found to remain attached to the agar for shear stresses of up to 3.4 Pa. This compares with mean physiological arterial shear stresses of less than 1.5 Pa for pulsatile flow.

Agar↗

Empirical mode decomposition and tissue harmonic imaging.

Empirical mode decomposition (EMD) is a relatively new technique used in the analysis of nonlinear and nonstationary time series. Previous signal-processing methods used for medical ultrasound have been based on the assumption of a linear time-invariant system. More recently, the technique of tissue harmonic imaging (THI) has become prevalent. This technique relies on the nonlinear propagation of the sound wave through the medium to disperse the signal energy into the harmonic frequencies of the transmitted signal. In this paper, results are presented from using EMD to process received ultrasound echo signals that have passed through nonlinear media. The Hilbert spectrum is used to demonstrate an interpretation of the physical process underlying THI that is based on the concept of intrawave frequency modulation, rather then the spreading of signal energy into harmonic frequencies. The technique of EMD is shown to be able to produce superior results to the bandpass filtering method of THI, even when the band width of the transducer was such that the second harmonic would be suppressed.

Artifacts↗

Phase II study of interferon gamma in malignant carcinoid tumors (E9292): a trial of the Eastern Cooperative Oncology Group.

PURPOSE: To determine the safety and efficacy of treatment with gamma interferon (IFNgamma) in patients with metastatic carcinoid tumor. PATIENTS AND METHODS: 51 patients were enrolled on this Phase II Eastern Cooperative Oncology Group (ECOG) study. Seventy five percent of them had hormonally active tumors. Treatment consisted of IFNgamma subcutaneously at a daily dose of 0.1 mg/m(2). Patents were evaluated for toxicity weekly for the first month and monthly thereafter; response was determined radiologically every 8 weeks. RESULTS: Patients received treatment with IFNgamma for a median of 17.9 weeks (range 2-175). Toxicity was generally mild and expected: 61% experienced noninfected fever and 21% developed granulocytopenia. Three patients (6%) had a partial response; there were no complete responses. Median time to progression was 5.5 months (95% confidence interval 3.9-11.1). The 1-year progression free rate was 28% (13.4-43.4%). Median survival was 42 months, with a 1-year survival rate of 67% (53.3-80%). DISCUSSION: This Phase II study demonstrated that therapy with IFNgamma in patients with metastatic carcinoid tumor was well-tolerated, but did not produce significant antitumor effects. The overall results were somewhat comparable to those previously seen with alpha interferons as well as cytotoxic drugs.

Adult↗

Doppler colour flow imaging and flow quantification with a novel forward-viewing intravascular ultrasound system.

The aim of this work was to investigate the potential of a novel forward-viewing intravascular ultrasound (IVUS) system for flow quantification and colour flow imaging combined with B-mode imaging. A stiff 3.8-mm diameter catheter was used to scan a 72 degrees sector ahead of its tip. Operating at 30 MHz, the catheter was integrated with an IVUS scanner and a radiofrequency (RF) data-acquisition system. RF data were software processed for producing B-mode images and deriving velocity estimates. Steady flow in the range of 45 to 146 mL/min toward the catheter, was used in wall-less tissue-mimicking phantoms simulating healthy lumen (8-mm diameter), 30% diameter symmetrical stenosis and 37% diameter eccentric stenosis. The system provided colour flow images and good estimation of peak velocity and volumetric flows (within 1% to 9% and 16% to 48%, respectively, of calculated values) at 5 to 7 mm distal to the catheter. A sector forward-viewing IVUS imaging/Doppler system is suitable for combined anatomical and functional assessment of stenosed vessels.

Blood Flow Velocity↗