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Biomedical subjects

Tom Glomsaker

Publications and source records attributed to Tom Glomsaker.

4 recordsLinked to original sources

[The use of stents in benign oesophageal conditions].

BACKGROUND: In recent years, self-expanding stents have been used to treat benign perforations and strictures of the oesophagus. METHODS: We conducted a PubMed search of literature from January 1st 1993 to February 7th 2005 on the use of self-expanding stents in benign oesophageal conditions. RESULTS: Only case reports and minor series are published in the literature; further studies are needed in order to define the future role of stents in benign disease. Present experience indicates that self-expanding metal stents can be used in benign perforations of the oesophagus, provided that the stent is removed once the perforation has healed. Removing such stents may, however, require significant endoscopic experience. When stents are used in benign strictures, a high number of complications should be expected; the literature is more ambiguous as to whether or not this procedure should be recommended. The development of retrievable plastic stents and bio-absorbable stents could alter the use of stents in the future.

Esophageal Perforation↗

[Perforated peptic ulcer--a 12-year material].

BACKGROUND: We aimed to explore patient characteristics, diagnostic and surgical procedures and results of treatment of perforated peptic ulcer at our hospital, and determine prognostic factors for death and postoperative complications. MATERIAL AND METHODS: Data were collected retrospectively from 102 patients with perforated peptic ulcer identified from a broad case file search of 590 patients from 1992 to 2003. Prognostic factors for dead and post-operative complications were analysed using both uni- and multivariate analyses. RESULTS: 48 men and 54 women, median age 71 (25 - 94) were evaluated. Surgery was performed in 100 patients, 2 received conservative treatment. 55 patients had perforated gastric ulcers (including prepyloric ulcers), and 47 patients had perforated duodenal ulcers. Out of the 100 patients who underwent surgery, 22 died and 39 suffered postoperative complications. By univariate analysis, high age, high ASA score and a long interval between initial symptoms and surgery were significantly associated with death (p < 0.01) and postoperative complications (p < 0.05). By logistic regression, high age (OR 1.1; 95 % CI 1.0 - 1.2; p = 0.04) and high ASA classification (OR 6.7; 95 % CI 1.4 - 33; p = 0.02) predicted death, and high ASA classification predicted postoperative complications (OR 4.2; 95 % CI 1.7 - 10.2; p = 0.002). INTERPRETATION: Perforated peptic ulcer is a disease with low incidence, high mortality and a high frequency of postoperative complications, mainly determined by the patient's age and ASA classification.

Adult↗