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Biomedical subjects

Tommaso Lombardi

Publications and source records attributed to Tommaso Lombardi.

15 recordsLinked to original sources

Periosteal distraction osteogenesis: preliminary experimental evaluation in rabbits and dogs.

The aim of this project was to evaluate the potential of bone formation by the distraction of periosteum. Distraction of calvarial bone in 12 rabbits at 0.25 mm a day caused formation of bone in 3 animals, and distraction at 0.5mm a day caused formation of bone in 2. A second trial of alveolar distraction in four dogs using a specifically-designed distraction device showed lack of stability of the device.

Alveolar Ridge Augmentation↗

Gingival involvement in a case series of patients with acquired immunodeficiency syndrome-related Kaposi sarcoma.

BACKGROUND: This case series presents the polymorphic clinical characteristics of gingival acquired immunodeficieny syndrome (AIDS)-related Kaposi sarcoma (KS), a malignancy that is gradually becoming uncommon in developed nations. An up-to-date overview of the related epidemiology, etiopathogenesis, histopathology, and treatment is provided, along with a pictorial guide to ease clinical diagnosis. METHODS: The oral/maxillofacial pathology records at Aristotle University and the University of Geneva were retrospectively reviewed. Thirty-two cases diagnosed with oral AIDS-related KS were retrieved between 1991 and 2004. KS diagnosis was established histologically by incisional biopsies from intraoral lesions. All charts contained clinical oral examination data, radiological images, and detailed photographic records. RESULTS: Thirteen patients (12 males and one female) presented with KS gingival involvement (40.6%). Eleven of the male patients were homosexual/bisexual men. The mean age of the patients at the time of intraoral KS diagnosis was 42.1 years, and the mean CD4 cell count was 103 (0 to 481). Gingival epidemic KS presented with various degrees of pigmentation and a wide range of clinical patterns, from relatively flat macules (early stage) to tumors with variable nodular morphology (advanced disease). Solitary or multiple gingival involvement may appear concomitantly with palatal and/or cutaneous lesions. CONCLUSIONS: Even though the incidence of intraoral KS had fallen precipitously in developed countries after the mid-1990s, gingival KS should be considered in the differential diagnosis of every pigmented gingival lesion. Periodontists are in a unique position to identify gingival involvement of intraoral KS and facilitate early diagnosis.

AIDS-Related Opportunistic Infections↗

Solitary superficial microcystic lymphatic malformation (lymphangioma circumscriptum) of the gingiva.

BACKGROUND: Lymphatic malformations are uncommon, hamartomatous, developmental aberrations of the lymphatic system. The case presented in this report is a rare solitary gingival involvement of a microcystic-type lymphatic malformation. METHODS: The lesion presented clinically as a small vesicular swelling of a buccal interdental papilla in a 16-year-old girl. Involved tissues were excised and submitted for routine histologic examination. The expression of the endothelial marker CD34 was investigated using immunohistochemical staining. RESULTS: A physical examination failed to reveal similar or other abnormalities elsewhere in the body of the patient, including the oral cavity. Histopathologic analysis of the specimen demonstrated the presence of subepithelial, thin-walled, distended vascular cavities forming confluent vesicles containing lymph. The dilated lymphatic formations were lined by flattened CD34-negative endothelial cells. These features were consistent with a microcystic gingival lymphatic malformation. To the best of our knowledge, only two additional reports of this malformation have been published to date, but both presented with bilateral gingival involvement. CONCLUSION: Even though lymphatic malformations are encountered very infrequently on gingiva, they should be considered in the differential diagnosis of related conditions with a vesicular clinical appearance.

Adolescent↗

Congenital intracranial frontotemporal dermoid cyst presenting as a cutaneous fistula.

BACKGROUND: Intracranial extension and a cutaneous sinus tract are rarely seen with craniofacial dermoid cysts, with few cases reported in the literature. METHODS: We report a case of a 1-year-old girl who was initially seen with a cutaneous fistula of the frontotemporal region, which revealed an intracranial dermoid cyst. RESULTS: The patient underwent a right lateral orbitotomy by a bicoronal approach. The cyst was seated within the lateral orbital wall, with intracranial extension through the temporal and sphenoidal bones to the dura of the temporal lobe. Histopathologic analysis confirmed the diagnosis of a dermoid cyst. CONCLUSIONS: Craniofacial dermoid cysts may be associated with a cutaneous sinus tract and/or intracranial extension. Failure to recognize and promptly treat these lesions may lead to a progressive skeletal distortion and/or recurrent infection with a potential for meningitis or cerebral abscess. Therefore, detailed CT and MRI scans are mandatory before surgical treatment of any cutaneous fistula in the head and neck region.

Brain Neoplasms↗

Enteric bacteria mandibular osteomyelitis.

Osteomyelitis of the mandible is a relatively rare inflammatory disease that usually stems from the odontogenic polymicrobial flora of the oral cavity. We are reporting 2 unusual cases of mandibular osteomyelitis resulting from enteric bacteria infection. In one patient, abundant clinical evidence suggested a diagnosis of a chronic factitious disease, whereas in the second patient no obvious etiology was found.

Bone Plates↗

Ultrasonography: a noninvasive tool to diagnose a caliber-persistent labial artery, an enlarged artery of the lip.

OBJECTIVE: Currently, practitioners use clinical and histopathologic examination to diagnose a caliber-persistent labial artery (CPLA). We illustrate the use of ultrasonography as a noninvasive diagnostic tool to visualize this enlarged artery of the lip. METHODS: We examined the lips of 3 patients with a suspected CPLA. We localized and determined the extension of the intralabial artery with ultrasonography, including pulsed and color Doppler analysis. We compared the sonograms to the clinical and histopathologic findings. RESULTS: Sonograms showed clear enlargement of the labial artery in the 3 cases. The course of the constant-diameter artery was either vertical or oblique from the depth of the lip to the surface of the mucosa. This vascular abnormality was confirmed by histopathologic examination. CONCLUSIONS: Ultrasonography and color Doppler imaging may be useful noninvasive tools for the diagnosis and preoperative evaluation, as well as the follow-up, of labial lesions related to a CPLA, thus eliminating the need for diagnostic surgery in typical pulsatile nodules. Ultrasonography may help distinguish a CPLA from other vascular lesions of the lip such as an aneurysm. Atypical cases or chronic ulcerations mimicking a cancer should undergo biopsy so that a malignant process is not missed.

Adult↗

Upper lip swelling caused by a large dentigerous cyst.

Swelling of the upper lip can result from various diseases such as salivary tumors, infectious and inflammatory diseases and cysts. Among the latter, dentigerous cysts, typically involving unerupted teeth, are sometimes associated with supernumerary teeth in the maxillary anterior incisors region called the mesiodens. We report an unusual case of a large dentigerous cyst associated with an impacted mesiodens in a 42-year-old male who presented with a slow-growing swelling in the upper lip.

Adult↗

Successful inferior alveolar nerve decompression for dysesthesia following endodontic treatment: report of 4 cases treated by mandibular sagittal osteotomy.

Endodontic overfilling involving the mandibular canal may cause an injury of the inferior alveolar nerve (IAN) resulting in disabling sensory disturbances such as pain, dysesthesia, paresthesia, hypoesthesia, or anesthesia. Two fundamental mechanisms are responsible for the injury: the chemical neurotoxicity and the mechanical compression caused by the extruded material. Although spontaneous resorption has been described for some materials, early surgical exploration with removal of the material and decompression of the IAN should be performed, irrespective of the material used, given that the importance of nerve damage increases with the duration of the injury. We report 4 cases of disabling dysesthesia and paresthesia following endodontic treatment of lower molars in which sagittal osteotomy was used to remove the endodontic paste and to perform nerve decompression. All the patients experienced immediate relief of dysesthesia and paresthesia.

Adult↗

Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia?

OBJECTIVES: To report our experience of subacute necrotizing sialadenitis (SANS), an unusual lesion of the minor salivary palatal glands, and to discuss its relationship with necrotizing sialometaplasia (NS). DESIGN: A retrospective review of records for patients with SANS identified between 1996 and 2001. SETTING: Academic center, referral center, and an ambulatory care center. PATIENTS: Three patients (1 woman, 2 men), aged 22, 23, and 40 years at diagnosis. INTERVENTION: All 3 patients underwent incisional biopsy. MAIN OUTCOME MEASURES: Clinical description of SANS, ability to make the diagnosis preoperatively, clinical evolution, histologic features, and comparison with the much more frequent NS. RESULTS: Three patients presented with a lateral palatal nodule (1 case bilateral, 1 case ulcerated) of 7 to 10 days' duration, 0.8 to 1.0 cm in size, slightly or not painful. No patient was correctly diagnosed prior to undergoing a biopsy. In all 3 cases, the biopsy specimen showed acinic necrosis surrounded by a dense polymorphous inflammatory infiltrate with atrophy of ductal cells but no squamous metaplasia. Healing occurred without any further treatment in up to 3 weeks. No recurrence was observed in 2 cases; 1 patient was lost to follow-up. CONCLUSIONS: SANS is a painful spontaneously resolving necrosis of the palatal salivary glands, easily misdiagnosed preoperatively. The main differences from NS are smaller size of lesion, scarcity of ulceration, and absence of squamous metaplasia. Although initially described as a new autonomous entity, SANS might be an early or minimal form of NS.

Adult↗

Intraoral venous malformation presenting with multiple phleboliths.

Venous malformations are the most common of all vascular anomalies. Phleboliths are described as characteristic of such malformations; furthermore, when they are encountered in the major salivary glands, they must be differentiated from salivary calculi. We report a case of an intraoral venous malformation in the left retromolar area with multiple phleboliths.

Aged↗

Anterior lingual mandibular salivary gland defect (Stafne defect) presenting as a residual cyst.

Lingual mandibular salivary gland inclusion (Stafne defect) is a developmental anomaly represented by a bone concavity usually containing submandibular gland tissue. The posterior mandible region, particularly at the angle and below the mandibular canal, is the common location, and the anterior mandibular variants occur rather seldom. The latter is usually observed in the premolar and cuspid region, or more rarely in the symphysis, as a round or ovoid radiolucency sometimes appearing superimposed over the teeth's apices, resembling a true cystic lesion or an odontogenic tumor. We report an additional case of anterior lingual mandibular salivary gland defect occurring in a 42-year-old white man. It presented as an asymptomatic radiolucency located on the left side of the mandible, in the region of an absent second premolar and first molar, above the alveolar canal, mimicking a residual cyst. Histopathologic examination of the "cyst" content revealed the absence of a cyst lining and the presence of normal sublingual gland tissue.

Adult↗

Peripheral giant cell granuloma associated with a dental implant.

A 56-year-old woman was referred for the treatment of a mandibular lesion that had been slowly increasing in size over a 6-month period. Intraoral examination revealed a reddish-purple nodule involving the attached vestibular gingiva around a machined-surface dental implant that had been placed 2 years earlier in the mandibular left second premolar region. Another implant had been placed in the mandibular left second molar region. The lesion was tender and bled easily upon tooth brushing. Radiographs showed inadequate abutment angulation. The healing caps on these 2 implants were loose and in contact with each other, preventing optimal oral hygiene. An excisional biopsy of the mass resulted in the diagnosis of peripheral giant cell granuloma. After the implants were gently curetted and scaled, they were cleaned using abrasive paste. At the last follow-up, 3 years later, there was no recurrence.

Dental Abutments↗