Biomedical subjects

Tongli Xia

Publications and source records attributed to Tongli Xia.

4 recordsLinked to original sources

PubMed2004

[Further studies on the relationship between benign prostatic hyperplasia and prostatitis].

Benign prostatic hyperplasia(BPH) and prostatitis are two common diseases in aging men. In recent years, the study of correlation between these two diseases has been paid more and more attention to. Some researchers presumed that inflammation is one of the most important causations of BPH, however, it is not profound enough on this etiologic hypothesis at present. The writer, on the base of his clinical experiences, dissertated the etiology of BPH, the pathologic figures of coexistence of BPH and prostatitis, and the presumption of inflammation promoting BPH on the molecular biology level. We hope our colleagues pay attention to this problem, and do more study on it.

Humans↗

PubMed2004

[Seminiferous tubule scores used for quantitative assessment of spermatogenic function of patients with azoospermia].

OBJECTIVE: To investigate the clinical reliability of quantitative evaluation by seminiferous tubule scores on spermatogenesis dysfunction, using the testis tissues of azoospermia patients for analysis of histological changes. METHODS: One hundred and twelve Chinese patients with azoospermia underwent open testicular biopsy and their testicular biopsy specimens were evaluated by 10-score (on testicular biopsy) and 5-Grade (on seminiferous tubule spermatogenesis) scale. The 112 patient, 22 to 46 years old [(29.0 +/- 4.4) years old] included 105 cases of obstructive and 7 cases non-obstructive azoospermia. Of the total number, there were 96 primary infertile cases and 16 secondary infertile cases with infertile marriage of 2-12 years [(4.0 +/- 2.8) years]. Various seminiferous tubule characteristics were categorized by 10-score as follows: [1] degenerating Sertoli cells and no germinal epithelium; [2] no germ cells and only Sertoli cells; [3] no spermatids and primary spermatocytes and only spermatogonia; [4] no spermatids and few primary spermatocytes; [5] no spermatids and numerous primary spermatocytes; [6] no mature spermatids and few round immature spermatids; [7] no mature spermatids and numerous round immature spermatids; [8] < 20 mature spermatids/tubules, germinal epithelium height < 80 microns and spermiation absent; [9] > 20 mature spermatids/tubules, germinal epithelium height < 80 microns and spermiation rarely < 80 microns; [10] > 20 mature spermatids/tubule and germinal epithelium height 80 microns and spermiation common. Seminiferous tubule spermatogenesis was catagorized by 5-Grade scale as follows: [1] tubular sclerosis; [2] sertoli cell only; [3] arrested spermatogenesis; [4] reduced spermatogenesis; [5] intact spermatogenesis. RESULTS: In terms of the 10-score scale on testicular biopsy, scores of 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 corresponded with total patient numbers of 5 (4.5%), 38(33.9%), 2(1.8%), 6(5.4%), 2(1.8%), 17(15.2%), 6(5.4%), 19(17%), 10(8.9%) and 7(6.3%), respectively. According to the 5-Grade scale on the seminiferous tubule spermatogenesis, Grades 1, 2, 3, 4 and 5 corresponded with 5(4.5%), 38(33.9%), 33(29.5%), 29(25.9%) and 7 (6.3%), respectively. Tubular diameter, the thickness of the lamina propria, the height of the germinal epithelium and serum FSH correlated with the average seminiferous tubule scores (P < 0.01). CONCLUSION: The seminiferous tubule scores obtained through testicular biopsy may provide important quantitative information concerning the etiology and pathogenesis and of azoospermia may serve as a helpful guide to the fundamental, clinical and therapeutical study of element, clinic and therapy.

Adult↗

PubMed2003

[Use of biopsy results to predict capsular perforation and seminal vesicle invasion in prostate cancer].

OBJECTIVE: To determine the ability of clinical tests to predict extraprostatic cxtension and seminal vesicle invasion. METHODS: Clinical T stage, TPSA total prostate specific antigen and pathologic features in systematic biopsy specimens were correlated with pathologic stage in 40 consecutive patients with clinically localized prostate cancer detected by systematic needle biopsies and treated with radical prostatectomy. RESULTS: Extraprostatic extension was observed in 20 patients (50%) and seminal vesicle invasion was noted in 11(28%). Preoperative variables predictors of extraprostatic extension and seminal vesicle invasion on univariate analysis were TPSA, Gleason score, the total length of cancer, the number of positive cores, the percentage of positive cores, the maximum length of cancer in any one core in the biopsy specimen and the percentage of cancer in the biopsy set P<0.05 . In multivariate analysis, TPSA, Gleason score, the total length of cancer and the percentage of positive cores in the biopsy specimens were the only significant predictors of extraprostatic extension and seminal vesicle invasion P<0.01 . A model was constructed to predict advanced stage: the TPSA >or=11 microg x L(-1) and Gleason score/5 and percentage of positive cores in the biopsy specimen >or=27% or the total length of cancer>or=7.3 mm P<0.001 . CONCLUSION: The combination of TPSA, the total length of cancer, Gleason score and percentage of positive cores in the biopsy specimens provides the best prediction of capsular perforation and seminal vesicle invasion. Models based on this combination of factors may be clinically useful to stratify patients for nonoperative treatment.

Aged↗

PubMed2002

[Gleason scores of prostate needle biopsy specimens and of radical prostatectomy specimens, a comparative study].

OBJECTIVE: To compare the Gleason scores of the prostate needle biopsy specimens with those of the radical prostatectomy specimens. METHODS: Gleason scoring was made on the needle biopsy specimens from 40 patients with prostate carcinoma and then on the radical prostatectomy specimens from the same patients. The Gleason scores of the two sets of matched specimens were compared. RESULTS: The Gleason scores were 2 approximately 9 (5.6 +/- 1.7) of the prostate needle biopsy specimens, significantly different from those of the radical prostatectomy specimens [4 approximately 10 (6.4 +/- 1.3), P < 0.05]. The Gleason scores coincided in 23 cases (57.5%) between the two groups. The Gleason scores of 15 needle biopsy specimens were significantly lower than those of the matched radical prostatectomy specimens with an underestimation rate of 37.5% and were higher in 2 needle biopsy specimens than in the matched radical prostatectomy specimens with an overestimation rate of 5.0%. The number of cases with the Gleason score < or = 6 in the needle biopsy group were 25, significantly less than that in the radical prostatectomy group (P < 0.01). The number of cases with the Gleason score > or = 7 in the needle biopsy group was 15, not significantly different from that in the prostatectomy group (P = 0.07). CONCLUSION: Prostate needle biopsy under-grades the Gleason scores in comparison with radical prostatectomy. Measures should be adopted to avoid underestimation of the tumor grade.

Aged↗