Biomedical subjects

Toru Torii

Publications and source records attributed to Toru Torii.

3 recordsLinked to original sources

PubMed2004

Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices.

A microfluidic device having both hydrophobic and hydrophilic components is exploited for production of multiple-phase emulsions. For producing water-in-oil-in-water (W/O/W) dispersions, aqueous droplets ruptured at the upstream hydrophobic junction are enclosed within organic droplets formed at the downstream hydrophilic junction. Droplets produced at each junction could have narrow size distributions with coefficients of variation in diameter of less than 3%. Control of the flow conditions produces variations in internal/external droplet sizes and in the internal droplet number. Both W/O/W emulsions (with two types of internal droplets) and oil-in-water-in-oil emulsions were prepared by varying geometry and wettability in microchannels.

Journal Article↗

PubMed2002

Chemical reactions in microdroplets by electrostatic manipulation of droplets in liquid media.

A microchemical reaction method involving microdroplets is proposed. Microdroplets are formed in a chemically stable medium on electric panel devices. These devices are substrates which have electrode arrays or electrode dots, and its surfaces are coated by an insulating film (such as Teflon or polypropylene) to prevent discharge and electrolysis of solutions. Microdroplets can be separately manipulated by a traveling electric field, which arises on applying a sequential voltage to the electrodes. Droplets moved smoothly at 1 Hz and voltage 400 V(0-p). Reagents were then put in droplets that were collided and coalesced, resulting in chemical reactions that included alkalization of phenolphthalein and the luciferin-luciferase reaction.

Journal Article↗

PubMed2002

Droplet formation in a microchannel network.

A method is given for generating droplets in a microchannel network. With oil as the continuous phase and water as the dispersed phase, pico/nanoliter-sized water droplets can be generated in a continuous phase flow at a -junction. The channel for the dispersed phase is 100 microm wide and 100 microm deep, whereas the channel for the continuous phase is 500 microm wide and 100 microm deep. For given experimental parameters, regular-sized droplets are reproducibly formed at a uniform speed. The diameter of these droplets is controllable in the range from 100-380 microm as the flow velocity of the continuous phase is varied from 0.01 m s(-1) to 0.15 m s(-1).

Journal Article↗