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Biomedical subjects

Toshifumi Kishimoto

Publications and source records attributed to Toshifumi Kishimoto.

9 recordsLinked to original sources
PubMed2005

[Alcohol dependence syndrome and BDIM (before-discharge intervention method)--report 4, the family members' self-reports about BDIM].

One hundred fifty-three inpatients with alcohol dependence syndrome were treated with the structured BDIM (Before-Discharge Intervention Method). 82 patients of them have participated to self-help group meetings or kept having therapy as our outpatients or inpatients during the study period. We chose the families of the 82 patients as our study subject Out of the study subjects who took part in BDIM, 64 families (117 persons) answered our questionnaire. Among them 63 families (101 persons) gave their described answers of impressions and opinions about BDIM, which were summarized as follows. (1) Through BDIM the family members gained second thought on their alcoholic family member (IP: identified patient) and they could tell their new view to IP. BDIM enabled them to tell IP their sincere feeling and hope for recovery of IP. BDIM empowered both IP and IP's family members. (2) The family members became to know IP's orientation on his or her disease. They came to know IP's denial and understand him or her as he or she was. (3) The family members felt emotional ties among themselves and IP through BDIM. When the family members of a dysfunctional family took part together in BDIM, they could know the feelings, thoughts, experiences and hopes one another. The family members had a precious experience of mutual understanding among themselves and IP to hope for recovery together. (4) The family members appreciated BDIM as a effective therapy. In BDIM many of them regarded highly of giving their letters to IP as a useful method to convey their feeling and thoughts calmly to IP. (5) On the other hand some family members pointed out the difficulty for themselves to write on BDIM. For family members who are not good at writing a letter or tend only to blame IP through their letters, writing and giving letters to IP is not appropriate as a therapy. If family members feel strong anxiety or fear, it is safe not to practice BDIM.

Adult↗
PubMed2004

High prevalence of the hepatitis C virus infection among the inpatients of schizophrenia and psychoactive substance abuse in Japan.

Prevalence of anti-HCV antibody in 1193 hospitalized patients (848 males and 345 females) in psychiatric department was investigated. Overall prevalence ratio was 9.1%, indicating significantly higher than that of healthy blood donors. In the classification of ICD-10, the prevalence of the inpatients diagnosed in schizophrenia group and psychoactive substance use group accounted for 6.2% and 13.8%, respectively. However, adequate reasons such as sanitary issues were not found to account for the high prevalence. Only the age of the patients could account for the high prevalence in the schizophrenic group. In the psychoactive substance abuse group, the sanitary issues might be a major cause of the very high prevalence of anti-HCV antibody, while other factors such as dysfunction of the immune system might be considered to account for it.

Adult↗
PubMed2004

[Alcohol dependence syndrome and BDIM (before-discharge intervention method)--Report 3. The patients' self-reports about BDIM].

The purpose of this study is to identify how the effects of BDIM are evaluated by patients who were practiced BDIM. 153 patients were treated by the structured BDIM (Before-Discharge Intervention Method) program. Among them, 82 patients (53.6%) have attended self-help group meetings or maintained the therapeutic relationship (as outpatients or inpatients) in the 4 months' study period. To identify the maintenance of the effects of BDIM, we made our questionaire that consist of the patients' choice of answer and the patients' self-reporting. 76 of 82 patients answered our questionaire. After 76 patients discharged from hospital, 4 1/3 years have passed on the average. Their positive answers are as follows. (1) I became aware that my drinking had bad effect on my beloved family. (2) I became aware that my family have kept compassion, expectation and appreciation for me. Their message treated me and strengthened my self-esteem. In addition, I accepted the reality of my drinking problems. (3) I recognized all my family members want my abstinence and functional communication. (4) I was extremely impressed by my family members' tears. Their tears made me decide strong abstinence. (5) I was empowered by my family members. Through BDIM, I felt a sense of security, self-esteem and freedom. (6) I thought that BDIM was a good treatment program. And I thought that the application of letters is useful to recover the patients from alcohol dependence syndrome. Their negative answers are as follows. (1) I thought it was impossible for me to be abstinent. (2) I couldn't keep the motivation of abstinence. (3) I thought BDIM was a negative treatment method. Some findings of this study are as follows: First, the letters which was handed from family members to the patient were read again and again, also preserved with much care. Therefore we get know that BDIM is useful for the patient to get and remember some good memories of the family members for a long time. Second, BDIM is helpful for the patients to become aware of their own drinking problems and realize the necessity of recovery.

Aged↗
PubMed2003

Minor physical anomalies in childhood and adolescent onset schizophrenia.

A modified version of the Waldrop scale (WS) was used to assess the prevalence of minor physical anomalies in schizophrenic patients (n = 71) and healthy controls (n = 65). The mean total WS score was 3.32 (SD 1.98) for the schizophrenic patients, significantly higher than that for the controls (2.19, SD 1.18). Minor physical anomalies were compared between two schizophrenic groups, divided on the basis of age at onset, early onset schizophrenia (EOS, onset under age 18 years) group and late onset schizophrenia (LOS, onset at or above age 20 years) group. The mean total WS score was 3.92 (SD 1.86) in the EOS group, significantly higher than the 2.59 (SD 1.79) in the LOS group. Minor physical anomalies are an indirect index for early prenatal central nervous system (CNS) maldevelopment; the present study indicated association between minor physical anomalies and EOS, thus a relationship between early prenatal CNS maldevelopment and EOS. These results support the hypothesis that EOS constitutes a subset of schizophrenia in which neurodevelopmental damage is largely involved.

Adolescent↗
PubMed2003

Effects of foods on the pharmacokinetics and clinical efficacy of quazepam.

The effects of foods on the pharmacokinetics and clinical efficacy of quazepam, a benzodiazepine derivative, in healthy persons were examined. Six healthy Japanese male subjects were randomly divided into three groups and each subject was treated with quazepam under the following three conditions by the crossover method. For the fasting state, subjects were administered 15 mg quazepam 11 hours after a meal. For the postprandial state, subjects were administered 15 mg or 30 mg quazepam 2 hours after a meal. Mean peak plasma concentration (Cmax) of quazepam was significantly higher [1.6-2.8 fold] with administration 2 hours after a meal than 11 hours after a meal. However, in regard to 15 mg of quazepam administration, the area under the curve (AUC) did not differ between administration 2 hours after a meal and 11 hours after a meal. In addition, differences were observed neither in other pharmacokinetic parameters or blood metabolite concentration under all of the study conditions, nor in clinical evaluation of subjective symptoms, complete blood count, or biochemical analyses between administrations 2 and 11 hrs after a meal. The present study showed that administration 2 hours after a meal did not affect subjective symptoms or physical functions so much; therefore it suggested favorable tolerance of this drug. However, it was also suggested that, in actual clinical use, it is important to evaluate the physical function including measurements of vital signs and hematological test results, carefully considering the effects of foods and daily life-style.

Adult↗
PubMed2002

A case of general paresis showing marked treatment-associated improvement of cerebellar blood flow by quantitative imaging analysis.

We describe a patient with general paresis who developed progressive dementia and a cerebellar syndrome including wide-based gait, slurred speech, and intention tremor. Quantitative analysis by means of a Patlak plot of single-photon emission computed tomography (SPECT) with 99mTc-ethyl cysteinate dimer showed generally low blood flow in the cerebrum and the cerebellum. After antisyphilitic therapy, blood flow in the brain, especially in the cerebellum, improved noticeably, as did the cognitive disorder and the cerebellar syndrome.

Adult↗