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Toshimitsu Momose

Publications and source records attributed to Toshimitsu Momose.

25 records · Page 2Linked to original sources
PubMed2002

FDG-PET after radiotherapy is a good prognostic indicator of rectal cancer.

UNLABELLED: In the management of rectal cancer after the combined therapy of the radiation and surgical operation, the evaluation of the prognosis is important. Although fluoro- 18-deoxyglucose positron emission tomography (FDG-PET) is considered as a useful tool for evaluation of therapeutic effect of this cancer as well as the other cancers, however, there are few articles that clearly describe the appropriate procedure of the FDG-PET in order to obtain the best prognostic value. The purpose of the present study is to compare several variations of a semi-quantification method, the Standardized Uptake Values (SUV) and to determine the most appropriate parameter, for the prognostic prediction and to propose the quantitative guideline of the FDG-PET. Especially, the authors focused on the SUV after radiotherapy, which had not been considered as a key quantitative value, as it was rather taken as a mere indicator of the therapeutic (radiotherapeutic) effect, not a direct indicator of the prognosis for the cancer itself. METHODS: Forty patients with rectal cancer in the lower rectal region underwent two series of FDG-PET study before and after pre-operative radiotherapy. Their SUVs were calculated from FDG-PET data and compared with the results of the long-term follow-up of the patients as well as with histopathological outcomes. RESULTS: All 40 patients had high FDG uptake before radiotherapy. The mean value of SUV before radiotherapy (SUV1) was 7.6. After radiotherapy, the mean value of SUV (SUV2) decreased to 4.2. There was a significant difference in SUV2 between the groups with and without recurrence (p < 0.05), however, SUVI or SUV ratio (SUV2/SUV1) displayed no significant difference with the incidence of recurrence. CONCLUSION: SUV2 was considered to be a good prognostic indicator for long-term prognosis of rectal cancer patients. SUV1 nor SUV ratio SUV2/SUV1 did not have the equivalent prognostic usefulness. Subsets of patients with SUV2 greater than 3.2 should be observed closely.

Adult↗
PubMed2002

Remodeling of the gliding surface after flexor tendon repair in a canine model in vivo.

Maintaining a smooth lubricated surface between the flexor tendon and sheath after tendon repair is very important for restoration of digit function. We studied the tendon surface after tendon repair mechanically in a canine model in vivo by measuring frictional force. One hundred and twenty flexor digitorum profundus (FDP) tendons were lacerated to 80% of their cross-section and repaired with either a modified Kessler (MK) or Becker (MGH) repair. The postoperative therapeutic regimen was either synergistic wrist and digit motion (SWM) or passive digit flexion and extension with the wrist fixed in 45 degrees of flexion (FIX). The dogs were sacrificed at one, three, or six weeks postoperatively. Thirty six FDP tendons from normal paws served as the control group, with each control tendon tested in two different conditions: intact and immediately after partial laceration and repair (0 time), making a total of five different timing points (intact, 0 time, one week, three weeks, and six weeks) for each repair type and each postoperative therapy. Frictional force between tendon and proximal pulley was evaluated after breaking any adhesions. Compared to intact tendons, friction was significantly increased immediately after tendon repair. The friction of the MK repair was significantly less than that of the MGH repair at all time and therapy groups, except at six weeks in the SWM group. For the MGH repair, at six weeks friction in the SWM group was significantly less than friction in the FIX group. This study showed that postoperative tendon gliding depends on the method of tendon repair and the postoperative therapy regimen. Furthermore, we have demonstrated that the gliding surface after tendon repair remodels with time.

Animals↗
PubMed2002

Effect of synergistic motion on flexor digitorum profundus tendon excursion.

Clinical and experimental studies have shown that postoperative rehabilitation is an important factor that improves digital function after flexor tendon repair. In the current study, the effect of synergistic wrist and finger motion therapy and fixed flexed wrist motion therapy on the in vivo gliding excursion was evaluated after repair of partial laceration of the canine flexor digitorum profundus tendon. The gliding excursion of the repaired tendons treated with synergistic wrist and finger motion therapy was significantly greater than that of tendons rehabilitated with the wrist fixation therapy, suggesting that wrist extension generates force that can pull the repair site through the pulley, thereby increasing passive excursion of the tendon. As a result of increased tendon excursion, synergistic therapy may improve the clinical outcome after repair of partial tendon lacerations.

Animals↗
PubMed2002

Effect of synergistic wrist motion on adhesion formation after repair of partial flexor digitorum profundus tendon lacerations in a canine model in vivo.

BACKGROUND: Therapy employing passive finger flexion and active finger extension with the wrist fixed in flexion is commonly used after flexor tendon repair. However, this method of rehabilitation may not produce full tendon excursion because of buckling of the tendon within its sheath with passive flexion. Studies of cadavera suggest that the use of synergistic wrist and finger motion may improve tendon gliding. The purpose of this study was to assess the effects of passive digital motion, performed with either wrist fixation or synergistic wrist motion, on adhesion and gap formation after flexor tendon repair. METHODS: Sixty-six dogs were randomly allocated to two groups. In each group, two flexor digitorum profundus tendons of one forepaw were partially (80%) lacerated and then repaired with a modified Kessler suture. In each group, a different postoperative therapy (wrist fixation or synergistic motion) was performed twice daily. The dogs were killed at one week, three weeks, or six weeks after surgery, and the repaired tendons were evaluated to determine the adhesion grade and adhesion breaking strength. RESULTS: The synergistic motion group had a significantly lower adhesion grade and significantly less adhesion breaking strength than the wrist fixation group at three and six weeks (p < 0.05). At one week, there was no significant difference between the two therapy groups (p > 0.05). CONCLUSIONS: Passive digital flexion and extension with synergistic wrist motion was an effective therapy after repair of partial zone-2 lacerations in a canine model.

Animals↗
PubMedDate not supplied

Reduced myocardial flow reserve in anatomically normal coronary arteries due to elevated baseline myocardial blood flow in men with old myocardial infarction.

BACKGROUND: Decreased myocardial flow reserve (MFR) in angiographically normal coronary arteries in patients with old myocardial infarction (OMI) has been reported. METHODS AND RESULTS: To clarify factors for the reduced MFR in OMI and to compare them with those in angina pectoris (AP), baseline myocardial blood flow (MBF) and MBF during dipyridamole administration were measured with nitrogen 13 ammonia positron emission tomography, after which MFR was calculated for 13 men with AP, 18 men with OMI, and 15 age-matched male control subjects. MFR was compared among the 3 groups in segments perfused by nonstenotic arteries. Baseline MBF in patients with OMI was significantly higher than that in patients with AP and control subjects. MBF during dipyridamole administration in patients with OMI was significantly lower than that in control subjects. MFR in patients with AP was 2.50 +/- 0.91 (P <.05 vs control subjects [3.47 +/- 1.25]), and that in patients with OMI was 1.83 +/- 0.61 (P <.01 vs control and AP groups). Ejection fraction (EF) in patients with OMI was significantly decreased compared with that in patients with AP. However, there was no significant difference in the mean score of the individual risk factors between patients with AP and those with OMI. In the pooled data with AP and OMI, baseline MBF and EF were significant for the reduced MFR. CONCLUSIONS: MFR and EF in patients with OMI were significantly decreased compared with those in patients with AP. Increased baseline MBF and decreased EF were significant factors for the reduced MFR in patients with AP and OMI.

Aged↗
PubMedDate not supplied

Interobserver variation in diagnosis of dementia by brain perfusion SPECT.

Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality, enabling the differential diagnosis of dementia. The purpose of this study was to measure interobserver variations in the diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 of Alzheimer's disease (AD), eight of multi-infarct dementia (MID), three of Pick's disease, five of other dementias, and 22 normal controls, were interpreted by ten nuclear medicine physicians with varying levels of experience. Brain MR images of the cases were then interpreted apart from SPECT. The physicians independently rated all of the diagnoses listed beforehand according to a five-point scale, with clinical information provided. Receiver-operating characteristic (ROC) curves and the area under the ROC curve (Az) were calculated. Az varied from 0.48 to 0.87. Mean Az's were significantly larger (p<0.05) in the diagnosis by SPECT than in that by MRI (0.715 and 0.629 for dementia vs. normal, 0.670 and 0.560 for AD or MID vs. normal, 0.610 and 0.416 for AD vs. normal, and 0.672 and 0.412 for AD vs. MID, respectively). Considerable interobserver variation was present in BP-SPECT interpretation. BP-SPECT may be more effective for the evaluation of dementia than MRI when the same nuclear medicine physicians interpret both images.

Aged↗