Biomedical subjects

Toshitugu Sugimoto

Publications and source records attributed to Toshitugu Sugimoto.

2 recordsLinked to original sources

PubMed2003

[The intracellular signal transduction systems of PTH and its effects on bone resorption and formation].

PTH binds to PTH/PTHrP receptor, one of seventh transmembrane receptor, which activates cAMP/PKA system through Gs protein and causes an activation of PKC and an elevation of cytosolic calcium through Gq protein. PTH affects bone cells through these dual second messenger signaling systems(cAMP/PKA and Ca/PKC system). Recent studies revealed that PTH stimulates bone resorption as well as bone formation mainly through cAMP/PKA system. Further work is necessary to clarify the downstream of the signal, such as CREB and AP-1.

English Abstract↗

PubMed2003

[Bisphosphonate for GnRH therapy].

GnRH therapy is useful for the treatment of various diseases, such as prostate cancer, endometriosis, uterine leiomyoma, based on its reduction of sex steroids. However, it causes osteopenia with high bone turnover in the mechanism similar with ovariectomy or castration. Bisphosphonate potently inhibits bone resorption, which subsequently inhibits elevated metabolic bone markers and osteopenia by GnRH therapy. The intravenous administration of pamidronate markedly inhibited osteopenia induced by GnRH therapy in some reports, but further study is necessary about the usage of bisphosphonate for osteopenia accompanied by GnRH therapy.

English Abstract↗