Biomedical subjects

Trevor W Dawson

Publications and source records attributed to Trevor W Dawson.

5 recordsLinked to original sources

PubMed2003

Comparison of electric fields induced in humans and rodents by 60-Hz contact currents.

Contact currents flow when a conducting object such as an animal touches conductive surfaces at different potentials. This completes a path for current flow through the body. These currents provide an additional coupling mechanism between the human body and low-frequency external fields to that due to direct induction effects. Recent research indicates that childhood exposure to residential contact currents may play a role in explaining any possible association between residential magnetic fields and childhood leukemia. To verify this hypothesis, laboratory experiments with rodents are planned. Thus, it is important to understand the relationship between fields induced in rodents and humans. Results from numerical computations are reported here. They are based on high-resolution anatomically based inhomogeneous models of adult and child male humans and male and female rats and mice, for a variety of 60-Hz contact current scenarios. It is hoped that this work will aid in the design of experiments involving rodents and in the interpretation of results as applied to humans. It is found that for geometrically similar models, the induced electric-field scales in an anticipated inverse-square manner with the geometric scaling factor. For dissimilar models, scaling can provide a crude estimate for translating induced field results between species. However, numerical modeling provides the most suitable analysis tool for more accurate estimates.

Abdomen↗

PubMed2002

Electric fields induced in humans and rodents by 60 Hz magnetic fields.

Numerical computations are used to evaluate electric field dosimetry for high-resolution anatomically based inhomogeneous models of a human male child, and male and female rats and mice, under exposure to 60 Hz uniform magnetic field sources of three perpendicular orientations. The goal is to compare the child data to previously computed adult dosimetry and to evaluate the accuracy of linear scaling of organ dosimetry between species. It is expected that this work will aid in the design and interpretation of experiments involving rodents. It is found that child-to-adult and mouse-to-rat organ dosimetry shows the expected linear dependence on the geometric scale factor between models. The comparison between mice and the human child shows that postural and individual organ differences do have significant effects, and that care is required in scaling-based extrapolation of rodent experiment results to humans. However, for unrestrained animals, linear scaling appears to be a reasonable and conservative approach. Most of the rodent organ fields, for at least one field orientation, are greater than those expected from linear scaling.

Adult↗

PubMed2002

Magnetic field exposures for UK live-line workers.

Dosimetry is evaluated for live-line workers exposed to 50 Hz non-uniform magnetic fields from typical high-voltage transmission lines in the United Kingdom. The configurations involve twin-, triple- and quadruple-conductor transmission line bundles. Scenarios include three worker postures for the twin and triple bundles, and four postures for the quadruple bundle. The postures are selected to simulate worst case scenarios representative of work practices and result in highest values of dosimetric measures in critical organs. Only single-phase bundles are considered, as adjacent bundles of differing phase result only in a small reduction of the dosimetric measures. Reported data include various measures of the electric field and current density induced in tissues, as well as of the current density averaged over 1 cm2 areas normal to the current flow. A value of this latter quantity of 10 mA m(-2) is suggested as a threshold for neural tissue in the UK and international regulations. Critical tissues considered in this study include the retina, spinal cord, brain and cerebrospinal fluid. Some discussion is devoted to problems associated with the concept of current-density averaging, and two algorithms are considered. For a nominal load of 1 kA per subconductor, averaged current densities exceed the guideline bounds, only for a small number of postures and bundle configurations, in the brain, retina and cerebrospinal fluid. Non-averaged current densities in the cerebrospinal fluid exceed the suggested bound for all scenarios modelled, as well as in the retina for three postures involving a quadruple bundle.

Algorithms↗

PubMed2002

Pacemaker interference by magnetic fields at power line frequencies.

Human exposure to external 50/60-Hz electric and magnetic fields induces electric fields within the body. These induced fields can cause interference with implanted pacemakers. In the case of exposure to magnetic fields, the pacemaker leads are subject to induced electromotive forces, with current return paths being provided by the conducting body tissues. Modern computing resources used in conjunction with millimeter-scale human body conductivity models make numerical modeling a viable technique for examining any such interference. In this paper, an existing well-verified scalar-potential finite-difference frequency-domain code is modified to handle thin conducting wires embedded in the body. The effects of each wire can be included numerically by a simple modification to the existing code. Results are computed for two pacemaker lead insertion paths, terminating at either atrial or ventricular electrodes in the heart. Computations are performed for three orthogonal 60-Hz magnetic field orientations. Comparison with simplified estimates from Faraday's law applied directly to extracorporeal loops representing unipolar leads underscores problems associated with this simplified approach. Numerically estimated electromagnetic interference (EMI) levels under the worst case scenarios are about 40 microT for atrial electrodes, and 140 microT for ventricular electrodes. These methods could also be applied to studying EMI with other implanted devices such as cardiac defibrillators.

Electromagnetic Fields↗

PubMed2002

Pacemaker interference by 60-Hz contact currents.

Contact currents occur when a person touches conductive surfaces at different potentials, thereby completing a path for current flow through the body. Such currents provide an additional coupling mechanism between the human body and external low-frequency fields. The resulting fields induced in the body can cause interference with implanted cardiac pacemakers. Modern computing resources used in conjunction with millimeter-scale human body conductivity models make numerical modeling a viable technique for examining any such interference. An existing well-verified scalar-potential finite-difference frequency-domain code has recently been modified to allow for combined current and voltage electrode sources, as well as to allow for implanted wires. Here, this code is used to evaluate the potential for cardiac pacemaker interference by contact currents in a variety of configurations. These include current injection into either hand, and extraction via: 1) the opposite hand; 2) the soles of both feet; or 3) the opposite hand and both feet. Pacemaker generator placement in both the left and right pectoral areas is considered in conjunction with atrial and ventricular electrodes. In addition, the effects of realistically implanted unipolar pacemaker leads with typical lumped resistance values of either 20 kohms and 100 kohms are investigated. It is found that the 60-Hz contact current interference thresholds for typical sensitivity settings of unipolar cardiac pacemaker range from 24 to 45 microA. Voltage and electric field dosimetry are also used to provide crude threshold estimates for bipolar pacemaker interference. The estimated contact current thresholds range from 63 to 340 microA for bipolar pacemakers.

Adult↗