Biomedical subjects

Tunçalp Demir

Publications and source records attributed to Tunçalp Demir.

3 recordsLinked to original sources

PubMed2005

The relationship between pulmonary function tests, thorax HRCT, and quantitative ventilation-perfusion scintigraphy in chronic obstructive pulmonary disease.

We have evaluated the relationship between pulmonary function tests (PFT), thorax high resolution computed tomography (HRCT) images and quantitative ventilation-perfusion (V/Q) scintigraphic studies in 16 male patients (mean age 65.6 +/- 5.5 years) with chronic obstructive pulmonary disease (COPD). The mean forced vital capacity (FVC) value of the patient group was 2352 +/- 642 mL (65.4 +/- 15.8%), whereas mean forced expiratory volume in one second (FEV(1)) was found to be 1150 +/- 442 mL (40.8 +/- 14.9%). The ratio of carbon monoxide diffusion capacity to alveolar ventilation (DLCO/VA) was 3.17 +/- 0.88 mL/min/mmHg/L, and the mean partial oxygen (PaO(2)) and carbon dioxide (PaCO(2)) pressures were 68.5 +/- 11.04 mmHg and 38.9 +/- 5.8 mmHg respectively. For each patient, thorax HRCT and V/Q scintigraphic images of both lungs were divided into upper, mid and lower zones during examination. Visual scoring for the assessment of emphysema on thorax HRCT were used and images were graded from mild to severe (< or = 25% - > or = 76%). Emphysema scores were found to be higher on upper zones with accompanying lowest V/Q ratios. DLCO/VA, DLCO, total emphysema scores, and individual emphysema scores of the upper, mid and lower zones were found to be correlated. As a conclusion, it can be stated that emphysematous changes in COPD patients are more apparent in the upper lung zones, which also have the lowest V/Q ratios.

Aged↗

PubMed2004

[One-year follow up results of Smoking Cessation Outpatient Clinic].

In this study we investigated the five-year-results of our smoking cessation outpatient clinic retrospectively. Out of 839 subjects admitted to our clinic during this time period 634 of them completed the one-year follow up period. 318 (50.2%) of these subjects were male and 316 (49.8%) of them were female. Subjects were divided into two groups. While one group received nicotine patch therapy, education and motivation the other group received just education and motivation. Mean age was 43.5 +/- 12 years. Nicotine patch therapy administered to 297 subjects and smoking cessation rates in this group were 46.8% at 15th day and 33.6% at the end of first year. The other group had smoking cessation rates of 11.8% at 15th day and 10.9% at the end of one year. Out of 185 subjects who did not smoke at the end of 15th day 98 of them were also not smoking at the end of one year. 449 subjects were smoking at the end of 15th day and just 26 (5.7%) of them gave up smoking at the end of first year. Therapy compliance was 82.2% at the 15th day and 23.2% at 12th week. Most frequent side effects were local skin reactions (13.8%) due to nicotine patches, irritability and nervousness (8.5%) and concentration difficulties (7.4%). In this retrospective analysis we concluded that nicotine replacement therapy in conjunction with education and motivation may be an effective method for helping individuals in giving up smoking. We also observed that smoking situation in first 15 days is a good predictor of long-term success.

Adolescent↗

PubMed2004

[Videothoracoscopic lung biopsy in the diagnosis of interstitial lung disease].

Video-assisted thoracoscopic surgery (VATS) is a diagnostic method, used with increasing frequency in recent years, in the diagnosis of interstitial lung diseases. There are significant differences in the diagnosis of diseases which are diagnosed with clinical, biochemical and radiological investigation and with pathological evaluation of material obtained by VATS. In our study, five patients with different clinical and VATS guided pathological diagnosis, were analyzed. VATS was applied to four patients with clinical and radiological diagnosis of lymphangioleiomyomatosis, hypersensitivity pneumonitis and idiopathic pulmonary fibrosis (IPF) (two patients) at the beginning and to another patient with pulmonary tuberculosis (Tbc) who was ARB positive and no regression could be achieved with anti-Tbc treatment at the third month. Clinical and pathological diagnosis was different in all patients. In a 22 year old female, who was thought to be lymphangioleiomyomatosis, was pathologically diagnosed as histiocytosis-X; in a 55 year old female, who was thought to be hypersensitivity pneumonitis, was diagnosed as sarcoidosis; in a 58 year old male, who was thought to be IPF, was diagnosed as nonspecific interstitial pneumonia. Sixty-two year old patient with ARB positive pulmoner Tbc who had no clinical and radiological regression with three month anti-Tbc therapy, and 65 year old male patient who was thought to be IPF were diagnosed by VATS as bronchoalveolar carcinoma. In conclusion; VATS is one of the most important methods for definite diagnosis of interstitial lung diseases, in patients with interstitial involvement.

Adult↗