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Biomedical subjects

U B Hoyme

Publications and source records attributed to U B Hoyme.

15 recordsLinked to original sources
PubMed1992

[Chlamydia infection and salpingitis].

Chlamydia trachomatis is the most prevalent etiologic agent in women with uncomplicated salpingitis. This presentation reviews the current aspects of etiology, diagnosis, therapy, prevention and complications of this disease. The other clinical manifestations of chlamydial infection are also discussed.

Chlamydia Infections↗
PubMed1991

[Salpingitis].

The etiology of salpingitis is polymicrobial, however, the particular pathogen is difficult to identify, even in laparoscopically obtained specimens. Chlamydia trachomatis, Neisseria gonorrhoeae, anaerobes and facultative anaerobic bacteria have to be covered by antimicrobial therapy. This article reviews the current aspects of etiology, diagnosis, therapy, prevention and complications of salpingitis.

Anti-Bacterial Agents↗
PubMed1990

[Roxithromycin versus doxycycline in the treatment of cervicitis. Prospective randomized multicenter study under practice-related conditions].

In a prospective randomized multicenter study Roxithromycin 150 mg or Doxycycline 100 mg was given b.i.d. p.o. for ten days to women with clinically diagnosed cervicitis. All women were seen as outpatients by one of eight licensed gynecologists in their private office in the Essen city area. With a cure and improvement rate of 100% in those women who completed therapy, Roxithromycin (n = 106) was as effective as Doxycycline (n = 104; 98%). At 90% Roxithromycin was as well tolerated as Doxycycline at 93%. Both drugs were clinically and microbiologically effective in eradicating Chlamydia trachomatis.

Adult↗
PubMed1989

[Chlamydia infections].

Chlamydia trachomatis is a pathogen with an intracellular developmental cycle. Sexually transmitted infection with serotypes D to K can lead to cervicitis, endometritis, salpingitis and urethritis, however, symptoms are commonly mild. Newborns of mothers with cervical infection or colonisation can acquire inclusion conjunctivitis and atypical pneumonia. An efficient prophylaxis is not available so far. Antimicrobial therapy should be initiated as soon as chlamydial infection is confirmed, e.g. with tetracyclines or erythromycin. Partner treatment is mandatory.

Chlamydia Infections↗
PubMed1989

[Bacterial vaginosis].

Bacterial vaginosis is the most prevalent microbiological cause of vaginal discharge. Sexual intercourse is considered as a main risk factor, however, bacterial vaginosis is not a true sexually transmitted disease and characterized as a dysbalance in the vaginal microbiological ecosystem. The diagnosis is based on the characteristic vaginal discharge, a pH greater than 4.5, a positive whiff test and on presence of clue cells. In therapy nitroimidazoles p.o. are considered as treatment of choice. Bacterial vaginosis is a significant risk factor for ascending as well as postoperative and pre- and post-partum genital infections.

Bacteria↗
PubMed1988

[Chlamydia trachomatis--detection of inflammatory diseases of the fallopian tubes].

The prevalence of Chlamydia trachomatis in tubal swabs obtained by laparoscopy was investigated in a prospective study. Specimens were collected from women with salpingitis (group 1), tubal infertility (group 2) and from controls, which were considered as being not infected and subjected to laparoscopy for other reasons (group 3). In the period 12/1980-8/1984 chlamydial infection was diagnosed, by means of the McCoy tissue culture method, in group 1 in 19% (16/85), in group 2 in 4% (10/250) and in group 3 in 0% (0/122). In a second period until 6/1985, positive chlamydial cultures were seen in 2% (1/44), 2% (2/110) and 0% (0/75) respectively, however, a simultaneously used IFT (Micro Trak, Syva Merck) was negative in all cases. In the third period until 12/1986, positive chlamydial cultures were obtained in 12% (9/77), 1% (1/137) and 4% (4/90) respectively. The sensitivity of a simultaneously performed EIA (Chlamydiazyme, Abbott) in women with salpingitis was 67%, the specificity was 97%. The EIA seemed to provide an alternative diagnostic method to culture when evaluating tubal specimens. In an additional trial, chlamydial complement fixation test was positive in 26% of a total of 90 women with tubal infertility (and negative tubal culture) vs. 6% in a control group of pregnant females (p less than 0.001). In conclusion, the reported results support the etiologic role of Chlamydia trachomatis as an important agent in salpingitis as well as in tubal infertility.

Bacteriological Techniques↗
PubMed1987

[Chlamydia trachomatis--histomorphologic finding in infection of the uterine cervix].

Uterine cervix biopsies from 20 women, in whom cell cultures were chlamydia-positive, were compared with 20 biopsies from chlamydia-negative women on the basis of inflammatory changes and proliferative epithelial reactions. There was a tendency towards severe chronic lymphocytic inflammations, especially those associated with the rare clinical picture of follicular cervicitis, and towards acute erosive forms and microabscesses to be found more frequently among the chlamydia-positive women. Hyperplasia of the reserve cells, which was probably connected with the more severe inflammatory reactions, with normotypical and dysplastic proliferations, was also seen more frequently in the chlamydia-positive group. The difficulty of distinguishing hyperplastic reserve cells from dysplastic squamous epithelia in cytological smears offers an explanation why such cases are relatively frequently overrated in cytological diagnosis. No chlamydia-typical changes of the cell nuclei or of the cytoplasm were found. It thus appears impossible to detect chlamydia in routine histological diagnosis.

Biopsy↗
PubMed1987

Chlamydial infections in gynaecology and obstetrics.

Chlamydia trachomatis is a sexually transmitted intracellularly growing rod, causing cervicitis, endometritis, salpingitis and urethritis. Inclusion conjunctivitis and pneumonia are the sequelae of maternal cervicitis in newborns. In treatment tetracyclines and erythromycin are the drugs of choice.

Chlamydia Infections↗