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U B Knudsen

Publications and source records attributed to U B Knudsen.

22 records · Page 2Linked to original sources

The influence of a urethral catheter and age on recorded urinary flow rates in healthy women.

Introducing a 7 F catheter into the urethra reduced the maximum and average flow rate and increased the micturition time significantly in healthy fertile and postmenopausal women. The menstrual cycle had no influence on the parameters. Urinary flow data were highly reproducible in both the fertile and the postmenopausal women. The flow rate-volume relation can be mathematically expressed, allowing for corrections when small voided volumes or small flow rates are obtained. Furthermore, this relation showed an increased flow time and a decreased flow rate in the postmenopausal women. This might indicate that the postmenopausal women had a reduced bladder contractility or a less compliant urethra.

Adult↗

Adult enuresis. The role of vasopressin and atrial natriuretic peptide.

In 8 adult patients with monosymptomatic nocturnal enuresis (age 18-44 years) we twice investigated the circadian rhythm of plasma vasopressin, plasma atrial natriuretic peptide, serum osmolality, serum electrolytes as well as urinary excretion in relation to urodynamic variables. Seven of the patients showed a lack of diurnal rhythmicity in plasma vasopressin at both diurnal studies with no night-time increase. The nocturnal urinary volumes exceeded the bladder capacities with an average of 155%. This was mainly caused by a large excretion of poorly concentrated urine during the first hours of sleep. Although a slight nocturnal peak in plasma atrial natriuretic peptide was found no clear pathophysiological role could be determined for this peptide. It is concluded that the previously established vasopressin production abnormality in juvenile enuresis seems to persist in adult enuretics.

Adolescent↗

Urodynamic investigations in healthy fertile females during the menstrual cycle.

Ten healthy, fertile women were investigated three times during the menstrual cycle in order to study a possible hormonal influence on the urodynamic parameters. On each occasion three urethral pressure profiles were recorded, and cystometry was carried out both in the supine and sitting position followed by pressure-flow studies. No significant changes attributive to menstrual cycle hormonal changes were observed in the profilometry data, the cystometric parameters or in the pressure-flow parameters. Both the short and long term reproducibility of the three times repeated urodynamic parameters were good. Measurements performed regardless of time in the menstrual cycle are thus representative in normal women.

Adult↗