Studies were performed in 42 cats in order to analyze the determinants of myocardial 201Thallium uptake. (1) Ventricular mass represents the major determinant of myocardial 201Thallium uptake. The inner (subendocardial) layer of the left ventricle storages 10-15 per cent more Thallium than the outer (subepicardial) layer, whereas the right ventricle has 201Thallium accumulation by 40 per cent less than the left ventricle. (2) Coronary perfusion increase as induced by intravenous injection of dipyridamole leads-at constant muscle mass-to considerable increase in myocardial 201Thallium uptake by 106 per cent. (3) Changes in myocardial oxygen consumption as induced by inotropic interventions are associated with considerable changes in the myocardial 201Thallium uptake. These results demonstrate that ventricular mass, myocardial flow and myocardial oxygen consumption are major determinants of myocardial 201Thallium uptake. Thus, by quantitiative determination of the myocardial 201Thallium uptake, a useful equivalent of the viability degree of the left ventricle, which itself is determined by mass, flow and metabolism, may be obtained.

Animals↗

PubMedDate not supplied

[First experiences with fluorodeoxyglucose-positron-emission tomography (FDG-PET) in the evaluation of painful total knee and hip joint replacements].

AIM: The aim of the study was to describe first experiences using FDG-PET in the examination of painful arthroplasties. METHOD: 12 patients prior to revision of a total hip or knee joint replacement underwent PET. Histopathology, microbiological analysis and intraoperative diagnosis were compared to preoperative PET findings. RESULTS: The analysis of intraoperative findings, of microbiological examinations and of histopathology showed that besides the well known determinants infection and early postoperative granulation tissue, polyethylene wear induced foreign-body reaction was a major cause for increased FDG consumption. CONCLUSION: In vivo imaging of marked foreign-body tissue reaction induced by polyethylene wear is feasible by FDG-PET. This observation, however, leads to reduced specificity of PET imaging for the diagnosis of periprosthetic infection.

Aged↗

PubMedDate not supplied

[[F-18]-fluorodeoxyglucose (FDG) positron emission tomography (PET) as a diagnostic for hip endoprosthesis loosening].

AIM: The purpose of this study was to examine the FDG-PET in respect of its diagnostic valency with regard to septic/aseptic loosening of lower limb prostheses. METHOD: 28 patients with 41 lower limb prostheses were examined by means of FDG-PET to evaluate septic/aseptic loosening of their hip prostheses. Therefore, a differentiated FDG-PET result interpretation subdivided into five categories was developed. The final diagnosis was based on operative findings with following culture and histological outcome. RESULTS: The worked-out categories showed a high agreement to the intraoperative macroscopic and histological results (n = 23 correctly positive, n = 1 false positive, n = 1 correctly negative and n = 3 false negative). CONCLUSION: With a subtly differentiated interpretation (categories I - V) of the qualitative glucose metabolism safe statements can be made regarding septic/aseptic endoprostheses loosening. This was impressively confirmed by the agreement of the FDG results with the histological results.

Aged↗

PubMedDate not supplied

The joint Task Group on clinical utility of labelled antibodies of the Society of Nuclear Medicine Europa (SNME) and the European Nuclear Medicine Society (ENMS).

In September 1985 a task group on the clinical utility of labelled antibodies was founded by the Society of Nuclear Medicine - Europe. This document was elaborated to report the aims and the programs of the group. In September 1986 the European Nuclear Medicine Society decided to participate in this initiative and a joint task group was created. INITIAL DOCUMENT: A. The aims to the Task Group are to monitor, co-ordinate and promote research and clinical application of techniques using radiolabelled antibodies in nuclear medicine. A.1. The Group should develop into a major point of reference, giving scientific and technical support to each member of the Society involved in this field. B. To pursue these purposes it will be necessary to develop the following: B.1. Criteria to evaluate the suitability of antigen-antibody systems for tumour detection and/or therapy. B.2. Criteria for quality control of radioimmunoreagents. B.3. Criteria for the prevention of adverse reactions or damage due to the reagent. B.4. Selection of suitable dosimetric methods for diagnostic or therapeutic applications. B.5. Elaboration of protocols for clinical experiments, including appropriate techniques to be applied in single cases. B.6. Organization of cooperative studies. C. The Task Group should promote: C.1. Informal meetings between the members of the Group. C.2. Workshops open to the members of the Society and other researchers. C.3. Publication of reports in appropriate journals.

Antibodies, Monoclonal↗

PubMedDate not supplied

[87mSr in the diagnosis of infectious and degenerative joint diseases].

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Adult↗