Biomedical subjects
Publications and source records attributed to U Berberoğlu.
Secretory breast carcinoma is a very rare condition in boys. An 11-year-old boy with secretory breast carcinoma is presented here. Modified radical mastectomy was performed by irradiation and chemotherapy because of axillary metastasis. There was no local recurrence or distant metastases in the follow-up period of 14 months.
We report herein the case of a 49-year-old woman with Pendred's syndrome who developed follicular carcinoma of the thyroid and invasive ductal carcinoma of the breast. To the best of our knowledge, this is the first case of different primary neoplasms developing in a patient with Pendred's syndrome.
AIMS: To carry out a retrospective study of male breast cancer over a 22-year experience. METHODS: Data from 121 male patients with breast cancer treated between the years 1972 and 1994 at the Surgical Clinic of Ankara Oncology Hospital were reviewed. Distribution of cases according to stage was: 2.5% stage I, 28.9% stage II, 55.4% stage III and 13.2% stage IV (AJCC staging method). The surgical treatment for 23 of the patients (19%) was Halsted's radical mastectomy or modified radical mastectomy. Seventy-three cases (60.3%) had total mastectomy without axillary node dissection and 25 (20.7%) had local tumour excision only. Seventy-two of 121 patients had adjuvant treatment. RESULTS: In general the prognosis of men with breast cancer was worse than for women. In the analysis of patients in stages I, II and III-A (operable disease group), the 5-year survival rates were 73% in axillary node-negative patients and 77% in those with tumours sized under 5 cm (P<0.001). In these patients, univariate analysis demonstrated that axillary status (relative risk of death in positive status vs. negative=3.6), tumour size (relative risk in T3 vs. T1-2=2), surgical treatment type (relative risk in simple mastectomy vs. radical mastectomy=1.9) and adjuvant chemotherapy (relative risk if no chemotherapy=1.4) were statistically significant factors associated with survival. CONCLUSIONS: Cox's regression model revealed that axillary status, tumour size and type of surgical treatment were the most important independent prognostic factors (P<0.001).
A retrospective analysis was performed to identify the risk factors associated with development of locoregional recurrent disease in patients with primary squamous cell carcinoma of the skin. Step-wise logistic regression analysis was used in this study, which consisted of 1,039 patients treated from January 1980 to December 1989 at Ankara Oncology Hospital. Locoregional recurrence occurred in 187 (18%) of these patients within a mean disease-free period of 15 months. Age, sex, anatomical location, size of lesion, lymph node, status at diagnosis, stage according to TNM classification, histopathologic grade, previous therapy, treatment modality, lesions arising from scar tissue (scar carcinoma), regional lymph node dissection, concomitant premalignant tumor of the skin, development secondary nonmelanotic skin carcinoma, and second malignancy were used as variables that could be correlated with locoregional recurrent disease. No correlation was found between development of recurrence and previous therapy, second nonmelanoma skin cancer, second malignancy, premalignant skin tumor, sex, or regional lymph node dissection. Although univariate analysis demonstrated that location, tumor size, patient's age, lymph node status, stage, histopathologic grade, scar carcinoma, and treatment modality were associated with an increased risk of locoregional recurrence, it was found that stage of the disease (P < 0.001), treatment modality (P < 0.01), tumor arising from scar tissue (P < 0.01), and histopathologic grade (P < 0.05) were statistically significant as risk factors of recurrence when a multivariate analysis was applied.
Completion thyroidectomy is defined as the surgical removal of the remnant thyroid tissue following procedures less than total or near-total thyroidectomy. The extent of surgical management for differentiated thyroid carcinoma (DTC) is controversial. Although some authors advocate subtotal thyroidectomy with lower complication rates, total or near-total thyroidectomy and completion thyroidectomy have been defended by others because of the improved survival and lower morbidity that is comparable with subtotal thyroidectomy. In this study, the incidence of residual tumor and surgical complication rates in patients who underwent completion thyroidectomy were investigated. The medical records of 165 patients undergoing completion thyroidectomy for DTC were reviewed. Seventy-seven (46.6%) of these patients were found to have residual tumor in the remaining thyroid tissue. Anaplastic transformation developed in two of these patients. Permanent bilateral recurrent laryngeal nerve palsy occurred in three patients, and permanent hypoparathyroidism was seen in one patient. We recommend completion thyroidectomy as an efficient and safe method of surgical treatment with a low complication rate for DTC.
A case of soft-tissue sarcoma of the posterior thoracic wall is presented with full-thickness resection and reconstruction of the defect with dehydrated human dura mater graft. The superiority and advantages of the graft are emphasised.