Biomedical subjects
Publications and source records attributed to U Brendel.
Follow-up examination were carried out on 43 patients with habitual or recurrent dislocation of the patella. The operation had been performed according to Ali Krogius. The subjective and objective results were summarized and the indication given hitherto was examined and corrected.
As reported previously [11] Antimycin A is effective in inhibiting sodium transport of the proximal tubule only when applied to the luminal side and in the presence of albumin. Therefore the interaction of Antimycin A with albumin was examined with the technique of equilibrium dialysis. It was found that Antimycin A was bound to albumin at five sites with a dissociation constant of 2.5 X 10(-6) M. This finding suggests that Antimycin A is taken up by the tubular cell as an Antimycin A/albumin complex via pinocytosis. In the pinocytotic vesicle this complex probably dissociates, and free Antimycin A is released into the cytoplasm where it can reach it's sites of action in the mitochondria and at the plasma membrane. This uptake mechanism might provide a general method to incorporate substances into the cell which do not penetrate the plasma membrane.
Explore the source record for details and available documents.
Explore the source record for details and available documents.