A method for repeated CSF sampling in the freely moving rat.
With the use of a holder mounted on the skull of rats, a cannula can be implanted so that one end rests on the atlanto-occipital membrane overlying the cisterna magna. Needles introduced through the cannula allow repeated access to the cisterna magna in the freely moving animal. This system is stable for periods of up to 4 weeks and is suited for repeated sampling of the cerebrospinal fluid.
Animals↗