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Biomedical subjects

U Consbruch

Publications and source records attributed to U Consbruch.

18 recordsLinked to original sources
PubMed1989

[Long-term catamnesis on the topic of uses and side effects of lithium prevention of phasic psychoses].

A lithium long-term catamnesis of 124 patients (107 manic-depressive and 17 schizoaffective psychoses) after more than 8 years of lithium prophylaxis led to the following results: 1.) Recovering: 30.3%. Improvement - particularly mitigation of the episodes of illness -: 56%. Lack of efficiency: 13%. Mean incidence of episodes of illness before lithium 0.57 per year, during lithium 0.36. Mean incidence of hospitalisation before lithium 3.4 years, during Lithium 7.1 years. Deterioration following discontinuation of lithium: 21 of 22 cases. 2.) Side effects at the beginning: 61.2%, finally 42.7% (incidence of struma 19.5% of tremor 19%, of polydipsia/polyuria 9.1%). 3.) EEG changes (general slowing-down and dysrhythmia, to a quarter focally accentuated): 59%. 4.) Normal results of haematologic and clinical-chemical investigations (28 parameter) except serum creatinine (10%), creatinine clearance (20.5%) and leucocytosis (13%). The authors discuss the reduced incidence of recovery and the quantity of side effects based on the aspect of long-term catamnesis. Further studies are necessary with regard to the selection of lithium-treated patients, to the duration of prophylaxis without efficiency and to the shift from initial efficiency to later inefficiency.

Adult↗
PubMed1982

[Eight years follow-up of lithium prophylaxis in patients of psychiatric-neurological practice (author's transl)].

A follow-up of patients under lithium-prophylaxis in a psychiatric neurological practice over a period of eight years is presented. It allowed for the evaluation of the therapeutic results of 54 of a total of 65 patients with affective psychoses. 32 patients remained free from any further episodes of illness (average duration of treatment 3.8 years). In another 14 patients (average duration of treatment 2.9 years) further episodes occurred but with obviously milder symptomatics. 8 patients (average duration of treatment 4.5 years) had to be considered as non-responders. This result largely consists with reports by other authors. Failures were mainly due to non compliance or diagnostic errors. The small number of patients stopping the prophylaxis without approval of the therapist (5 out of 65 patients) may be attributed to a rigid preselection of patients and to the fact that the conditions for a good patient compliance are more favourable in the practice with its tight and continuous doctor - patient relationship than in a typical out-patient department. Intoxications or other lithium-induced complications did not occur. Generally side effects could be well controlled and/or were tolerated by the patients. Discontinuance of therapy due to side effects was necessary in 3 cases.

Affective Disorders, Psychotic↗
PubMed1979

[Lithium balance in mania].

Lithium balance studies were performed in 19 patients suffering from mania and 6 patients suffering from depression. The following results were obtained: (1) The mean daily requirement for lithium in the manic patients was 52 mM, in those with depression 30 mM (additional requirement in manic patients 73%). (2) Renal elimination of lithium, after optimal blood lithium levels had been reached, was 76% in mania and 97% in depression (retention in manic patients 21%). (3) In mania there was an unchanged lithium half-life time (12-13.5 h). (4) In mania and depression no significant differences in lithium and creatinine clearance were noted. (5) Standard diet or unrestricted sodium chloride administration did not significantly influence the lithium requirement or lithium retention. After exclusion of a renal or dietetic cause for increased lithium requirement or retention during mania, the existence of a 'lithium pool' dependent on the presence of a manic psychosis seems probable. As a result of this, somatic influences on endogenous psychosis have to be taken into account.

Adolescent↗
PubMed1978

[Lithium balance in healthy volunteers].

Lithium sulphate in a sustained-release preparation was given to three healthy volunteers during 10 days. The following results were obtained: 1. The daily requirement needed for maintenance of an efficient lithium serum level from 0.7 to 0.8 mmol/l amounts to 30 mval. A steady state level of the serum lithium concentration was achieved after 4 to 5 days. 2. The mean value of lithium clearance amounts to 26.8 ml/min. 3. Approx. 98% of the ingested lithium could be recovered from the urine. 4. 6 days after drug withdrawal the lithium concentration in serum and urine was determined as 0. This result shows that the study of lithium balance can rely on renal excretion excluding other pathways. It is discussed that the simultaneous ingestion of psychortropic drugs and sodium chloride may influence the elimination rate of lithium.

Adult↗