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Biomedical subjects

U Dauer

Publications and source records attributed to U Dauer.

4 recordsLinked to original sources
PubMed1987

[Follow-up care in colorectal adenoma].

From 1980 to 1985, 319 adenomatous colorectal polyps were removed in 297 patients. All patients were entered into a computerized follow-up programme with yearly follow-up. The recommended follow-up was rejected by 58 patients (22.1%). 93 new adenomatous polyps were found in the course of the follow-up in 53 patients (35.8%), five of them histologically invasive carcinomas. The proportion of carcinomas was lowered from 10.6% at first examination to 5.4% in the follow-up period. Size of polyp correlated significantly with carcinomatous change. Size of the adenomas removed at follow-up was markedly smaller than that removed at first examination (69.4% smaller than 1 cm compared with 44.2% at follow-up). In six patients with early invasive carcinoma, further resections were undertaken, while in six others only the polyps were removed. But local recurrences occurred in both groups. Regular follow-up after polypectomy of colorectal adenoma is thus essential.

Adolescent↗
PubMed1987

[Endothelial function and arteriosclerosis].

Elevated levels of plasma LDL have been correlated with morphological endothelial damages, e.g. reduced antithrombogenity of endothelial cells. Numerical and functional defects of endothelial cells probably influence the necessary separation of blood fractions from subendothelial tissues in a negative sense. In order to describe an imaginable endothelial dysfunction with respect to LDL transport we examined human umbilical venous endothelial cells (HUVEC) in culture under physiological flow conditions. HUVEC in culture after incubation with a LDL concentration of 100 micrograms/ml medium were exposed to defined levels of physiological shear stress, fixed with formalin and stained with oil-red-O. After documentation of oil-red-O staining with a photomicroscope, the amount of stain has been characterized semiquantitatively with the help of an image-analysis system (IBAS II/Zeiss). HUVEC not exposed to shear stress only showed a marginal oil-red-O staining at the cell surface. If they were exposed to shear stress of 0.5 dyn/cm2 they showed in orthogonal view an average increase of 1.3%, in cross-sectional view an average increase of 0.3%. HUVEC exposed to shear stress of 2.5 dyn/cm2 showed in orthogonal view an average increase of 4.6%, in cross-sectional view an average increase of 8.7%.

Arteriosclerosis↗
PubMed1986

Stress fibres (SF) in human endothelial cells (HEC) under shear stress.

Human umbilical veinous endothelial cells are cultured on artificial substrates precoated with extracellular matrix from bovine corneal endothelial cells. These cultural conditions help cells to keep an elevated maintenance level for otherwise unusual time intervals. Integrity of endothelial cell layers is of special interest for nondisturbed blood circulation. Therefore we look after mechanisms of cell--cell and cell--substrate--adherence. Here we focus on stress fibres, microfilaments, which seem to play an important part in cellular adherence phenomena. Since endothelial cells in vivo are constantly shear stressed by the blood stream we investigated cell--substrate interactions in vitro under dynamical conditions with the help of a modified cone--plate rheometer originally designed for hemorheology. It can be demonstrated in these shearing experiments that toxical substances influence the organization of stress fibres.

Actin Cytoskeleton↗