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Biomedical subjects

U Demeler

Publications and source records attributed to U Demeler.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Barraquer-silk (8 x 0) and polyglactin 910 (8 x 0) in corneo-scleral incisions of rabbit eyes. A histological study].

Barraquer-silk (8 x 0) and Polyglactin 910 (8 x 0) were histologically examined in corneo-scleral incisions of rabbit eyes. Wound healing using both suture materials was complete after two weeks, as observed by light microscopy. Barraquer-silk excited more cellular reaction than Polyglactin 910. Absorption of Polyglactin 910 suture began 18 days after surgery whilst Barraquer-silk did not begin to absorb until 42 days had passed.

Animals↗
PubMed1981

Fluorescence angiographical studies in the diagnosis and follow-up of tumors of the iris and ciliary body.

The clinical and detailed angiographical findings taken during the follow-up of 182 patients with tumors of the iris and the ciliary body reported. On the basis of different angiographic staining patterns, these tumors were divided into three groups. Group I: Clinically, as a rule darkly pigmented, slightly or nonprominent tumors, which do not take up fluorescein at all, i.e. no staining of the tumor of its surroundings during the whole angiogram. 107 patients with such a tumor type did not show any clinical or angiographical changes during several years of follow-up. Those tumors which were excised (4) proved to be nevi. We therefore believe this fluorescein pattern indicates a benign lesion so that examination every 6 months suffice. Group II: These are usually less pigmented and only slightly prominent and have their own vascular network. On fluorescein angiography there is dye leakage within the tumor and into the surrounding iris stroma as well as into the aqueous humor. Of a total of 52 cases 9 were excised via iridectomy or iridocyclectomy. Of these 5 were shown to be benign nevi, 4 however were diagnosed as malignant melanomas. We therefore classify this fluorescein angiographical pattern as belonging to potentially malignant tumors, needing frequent controls, i.e. at 3-month intervals. Group III: Clinically these tumors are usually darkly pigmented, extremely prominent and mostly situated in the peripheral iris, originating here or spreading forward from the ciliary body. They are usually vascularized and show - if the melanin content is not too dense - early mottled staining in the vicinity of the tumor. They furthermore always have a marginal central borderline fluorescence as a typical sign, often accompanied by dye leakage from normal iris vessels, representing so-called 'tumor iritis'. 18 tumors of this type were excised via iridocyclectomy or enucleation and all were shown to be malignant melanomas of the iris or the ciliary body on histopathological examination. This fluorescence pattern group of tumors should always be regarded as definitely malignant, and therefore need prompt surgical excision.

Adult↗
PubMed1980

Management of retinal venous occlusion.

The conservative treatment as well as photocoagulative therapy of central retinal and branch vein occlusion is reported on. In spite of encouraging reports in the literature on medical treatment with anticoagulants and antithrombocyte aggregation drugs, photocoagulation via the xenon-arc or argon-laser method should be preferred. The indication for photocoagulation depends on fluorescein angiographical controls with the ability to distinguish between reversible and irreversible retinal changes, thus assuming prognostic significance. In cases of central retinal vein occlusion one should begin with photocoagulation soon after the onset of the disease to prevent new vessel formation in the retina and iris with following vitreal hemorrhage and secondary angle-closure glaucoma. In cases of branch vein occlusion a more conservative approach with regular fluorescein angiographical controls are proposed, because the natural course and the prognosis without therapy will be good in most cases.

Arteriosclerosis↗
PubMed1979

[Diabetic changes in the blood vessels of the iris. A fluorescence angiographic study].

Fluorescence angiography of the iris was performed on 135 patients with diabetes mellitus. The changes in the iris were classified as iridopathia diabetica simplex and iridopathia diabetica proliferans, corresponding to similar changes in diabetic retinopathy. Thus punctata leakage of dye, especially around the pupillary margin, was classified as iridopathia diabetica simplex, whereas additional, angiographically verified new vessel formation was described as iridopathia diabetica proliferans. 123 of 135 patients (91.1%) showed diabetic changes of the iris. Of these 85 (62.9%) had iridopathia diabetica simplex changes and 38 (28.2%) had iridopathia diabetica proliferans changes. The incidence of diabetic iris changes appeared unrelated to age but appeared to increase with duration of diabetes. A correlation between the onset of diabetic vascular changes of the iris and of the retina could not be confirmed: the diabetic changes in the iris vessels can precede those of the retina whereas, on the other hand, almost all patients with a diabetic retinopathia also show an iridopathy. Iris angiography is of clinical value because first signs of diabetic vascular damage can be seen in the iris earlier than in the retina, the iris appearing normal on slit-lamp microscopy.

Diabetes Complications↗
PubMed1978

[Irisangiography of rubeosis iridis].

In 66 patients with a rubeosis iridis due to diabetes mellitus (25), old central retinal vein occlusion (22), long-standing secondary angle-closure glaucoma (6), total old retinal detachment (3) and chronic uveitis (10), iris angiography was performed. Typical angiographical findings were found in some of the cases. One can differentiate the different modes of formation of the new vessels; angiographically, rubeosis iridis is never a congestion of preexisting vessels but rather an active vascular proliferation which is always permeable to fluorescein.

Aged↗
PubMed1978

[Iris angiograms in malignant melanoma of the uvea].

Iris angiograms were performed in 17 cases of uveal malignant melanoma, which were later histologically confirmed. In those 12 patients in whom the tumour was confined to the choroid, the angiograms revealed a punctate leakage of dye at the pupillary margin, a delayed filling of the vessels in certain areas and definite new vessel formation corresponding to rubeosis iridis. These changes were mostly found in those areas of the iris which corresponded to the choroidal tumour. Five peripheral choroidal melanomas, which involved the ciliary body and encroached into the anterior chamber structures, showed additionally to the dye leakage at the pupillary margin a very light central tumour "borderline fluorescence".

Adult↗
PubMed1978

[Keratoplasty in children and juveniles].

The morphological and functional results of 42 penetrating keratoplasties performed on 38 eyes of 36 children are reported on. Surgical indications, contraindications and postoperative complications are discussed. Emphasis is placed on the close cooperation between the clinic, the practitioner responsible for the aftercare, and the parents of the child.

Adult↗
PubMed1978

[Iris angiography in the persistent pupillary membrane].

With fluorescence angiography of the iris vessels, in a 52-year-old female patient, blood-containing vessels with thread-like remnants of a persistent pupillary membrane could be demonstrated. From these vessels, a diffuse dye leakage was seen from free-floating remnants in the anterior chamber as well as from those which were inserted at the anterior lens capsule. At the pupillary margin, a diffuse fluorescence from the capillary network of the sphincter pupillae was visible, whereas the rest of the iris showed a normal angiographical pattern.

Female↗
PubMed1978

Adenoma of the iris pigment epithelium.

The clinical, fluorescein angiographical and histopathological findings of a mucous-producing adenoma apparently arising from the iris pigment epithelium is reported, and the differential diagnosis is discussed. Benign epitheliomas of the iris pigment epithelium are exceedingly rare and are usually heavily pigmented tumors. This appears to be the second documented case of a nonpigmented benign epithelioma of the iris.

Adenoma↗
PubMed1978

[Control of the course of iris tumors with the aid of fluorescence angiography].

The clinical and fluorescence-angiographical control findings of 79 iris tumours are reported. According to the angiographical pattern, these tumours could be divided into three distinct types which correlated to the histopathological findings, if available. Thus, a type I tumour tends to run a benign course; type II we regard as potentially malignant and type III as definitely malignant. Furthermore, an increase in tumour size can be more exactly determined by iris angiographical controls than by other methods of documentation.

Adolescent↗
PubMed1978

[Iris angiography studies in patients with diabetes mellitus].

Fluorescence angiography of the iris was performed on 75 patients with diabetes mellitus. The changes in the iris were classified as iridopathia diabetica simplex (ID-s) and iridopathia diabetica proliferans (ID-p), corresponding to similar changes in diabetic retinopathy. Thus punctate leakage of dye, especially around the pupillary margin, was classified as ID-s, whereas additional, angiographically verified new vessel formation was described as ID-p. 69 of the 75 patients (92%) showed diabetic changes of the iris. Of these, 50 (67%) had ID-s changes and 19 (25%) had ID-p changes. The incidence of diabetic iris changes appeared unrelated to age but appeared to increase with duration of the diabetes. A correlation between the onset of diabetic vascular changes of the iris and that of the retina could not be confirmed: the diabetic changes in the iris vessels can precede those of the retina whereas, on the other hand, almost all patients with a diabetic retinopathia also show an iridopathy. The clinical value of iris angiography lies therein that the first findings of diabetic vascular damage can be seen in the iris earlier than in the retina, the iris appearing normal on slit-lamp microscopy.

Adult↗