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Biomedical subjects

U Ewers

Publications and source records attributed to U Ewers.

At least 19 recordsLinked to original sources
PubMed2000

Decrease of PCDD/F levels in human blood--trend analysis for the German population, 1991-1996.

More than 500 whole blood samples of normal subjects from Germany collected in 1991-1996 have been analyzed for polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) by capillary gas chromatography/high-resolution mass spectrometry. Over the examined time period a continuous decrease of the PCDD/F concentrations in human blood was observed. The mean levels found were about 42.7 pg I-TEq/g (lipid basis) in 1991 and 20.7 pg I-TEq/g (liquid basis) in 1996 [median: 40.8 and 19.2]. A reduction to about half was found for most congeners. Each 1-year subset of the entire collective shows a positive correlation of the PCDD/F blood levels with age for most of the congeners, the sum values, and the calculated toxicity equivalents. For statistical evaluation a multiplicative model was used: Concentration in blood = A x ageB. The correlation is mostly pronounced for lower chlorinated PCDD and for 2,3,4,7,8-PentaCDF.

Adolescent↗
PubMed1999

Reference values and human biological monitoring values for environmental toxins. Report on the work and recommendations of the Commission on Human Biological Monitoring of the German Federal Environmental Agency.

This article describes the working principles and working procedures of the Commission on Human Biological Monitoring, which was established in 1993 as a joint commission of the Federal Health Office (Bundesgesundheitsamt) and the Federal Environmental Agency (Umweltbundesamt) in Germany. One of the main tasks of the commission is to develop scientifically based criteria for the application of human biological monitoring and for the evaluation of human monitoring data in environmental medicine. In principle, two different kinds of criteria are recommended: (a) reference values and (b) human biological monitoring values (HBM values). Reference values are intended to indicate the upper margin of the current background exposure of the general population to a given environmental toxin at a given time. Reference values can be used to identify subjects with an increased level of exposure (in relation to background exposure) to a given environmental toxin. However, reference values do not represent health-related criteria for the evaluation of human biological monitoring data. HBM values are derived from human toxicology and epidemiology studies and are intended to be used as a basis for a health-related evaluation of human biological monitoring data. Usually the commission recommends two different HBM values: HBM I, the concentration of an environmental toxin in a human biological material (usually blood, serum, plasma, or urine) below which there is--according to the knowledge and judgement of the commission--no risk for adverse health effects in individuals of the general population: and HBM II, the concentration of an environmental toxin in a human biological material (usually blood, serum, plasma, or urine) above which there is--according to the knowledge and judgement of the commission and with regard to the environmental toxin under consideration--an increased risk for adverse health effects in susceptible individuals of the general population. The HBM I value can be considered a kind of alert value (from the toxicological point of view), whereas the HBM II value represents a kind of action level, at which attempts should be undertaken to reduce the level of exposure immediately and to carry out further medical examinations. Values between HBM I and HBM II should be considered a warning signal of the need to control the analytical measurement and to reduce the level of exposure of the concerned individual as reasonably as is achievable. At present, reference and HBM values are available for lead in blood, for cadmium and mercury in blood and urine, and for pentachlorophenol in plasma/serum and urine. Reference values have been established for some polychlorinated biphenyls in blood and plasma as well as for hexachlorocyclohexane and hexacholorobenzene in blood as well as for some organochlorine in human milk.

Adolescent↗
PubMed1999

Sick building syndrome in an office building formerly used by a pharmaceutical company: a case study.

In the past two decades, a group of health problems related to the indoor environment--generally termed sick building syndrome (SBS)--has emerged. We present an investigation of SBS in employees of a ministry working in a naturally ventilated office building that formerly had been used by a pharmaceutical company. A preceding environmental monitoring had failed to identify the cause(s) for the complaints. We conducted a questionnaire-based investigation and categorized the building sections and rooms according to their renovation status and their former use, respectively. The highest level of complaints was found among the employees working in rooms that in the past had been used for the production or storage of various pharmaceutical products suggesting that pharmaceutical odors may be a risk factor for SBS. Clinical laboratory tests did not show any unusual results. We conclude that the former use of a building for production and storage of pharmaceutical products should be considered as a possible risk factor for complaints about indoor air quality, e.g., when advising about or planning for renovations of buildings formerly used for production, handling, or storing of chemicals.

Adult↗
PubMed1999

[Statistically evaluated 95% prediction ranges as alternative to reference ranges exemplified by polychlorinated dibenzo-p-dioxins/dibenzofurans and lead].

Using the 95% prediction limits of an age-related multiplicative regression model describing the datasets of blood examinations carried out on subjects suspected of having been exposed to lead and to polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/F), it was shown that the relevant curves can be used as an alternative to reference ranges describing the actual background exposure to these pollutants. The upper limit of the actual German background exposure can be estimated by the following equations: PCDD/F as International Toxicity Equivalents in the age range of 10-70 years [pg/g lipid basis] = 1.64.age0.871 and lead in the age range of 15-80 years [microgram/l] = 18.15.age0.3638.

Adolescent↗
PubMed1998

[Blood tests for PCB in teachers at a heavily PCB-polluted school].

The levels of PCB 28, 52, 101, 153, 138 and 180 were determined in blood samples of subjects (mainly teachers; n = 18) who had worked in a PCB-contaminated school-building for many years (average: 14.2 years). The PCB concentrations in indoor air ranged up to 13,500 ng/m3. For comparison PCB blood levels were determined in 18 teachers working in schools not contaminated by PCB. The subjects of the reference group were matched with the exposed subjects with respect to age and gender. PCB 28, 52 and 101 were not detectable in the blood samples (detection limit: 0.1 microgram/l). In the exposed subjects blood levels of PCB 153 and 138 were, on average, slightly higher and the levels of PCB 180 slightly lower when compared with the reference subjects, but the differences were not statistically significant. The levels of PCB 153, 138 and 180 increased with age. With the exception of two subjects the levels of these congeners were below the reference values proposed by Kappos et al. The results show that inhalative exposure to PCB 153, 138 and 180 is very low in comparison to PCB background exposure via food. Due to rapid metabolisation and elimination the blood levels of PCB 28, 52 and 101 are usually very low.

Adult↗
PubMed1997

[Human biomonitoring--studies of arsenic, lead and PCDD/F in inhabitants of a contaminated residential area].

The levels of arsenic in urine, lead in blood, and PCDD/F in blood fat were determined in 12 subjects living in a residential area where the soil was contaminated by arsenic, lead, PCDD/F and other pollutants. Six residents (group I, mean age 56 years) were living on the contaminated site for at least 35 years, and had consumed home-grown vegetables and fruits as well as self-produced animal products (eggs, meat). Six residents (group II, mean age 47 years) had been living on the contaminated site for an average period of 9 years, and had consumed only minor amounts of home-grown vegetables and fruits, but no self-produced animal products. Some of them had skin contact with contaminated soil during excavation and garden work. For comparison, blood and urine samples of subjects living in the same region but not exposed to soil contaminants were investigated for the above mentioned parameters. The reference subjects were selected by age and gender in order to form matched pairs with the exposed subjects. The levels of arsenic in urine and lead in blood did not differ significantly between the residents of the contaminated area and the reference subjects. With regard to PCDD/F in blood fat a significantly increased PCDD/F-body burden was found for the subjects of group I (median: 41.5 pg I-TE/g fat, range: 18.0-54.6 pg I-TE/g fat; reference group, median: 20.3 pg I-TE/g fat, range: 12.2-30.5 pg I-TE/g fat), whereas the subjects of group II had only a moderately, but not significantly increased PCDD/F-body burden (median: 23.4 pg I-TE/g fat, range 13.1-45.8 pg I-TE/g fat) when compared with the reference group (median: 13.9 pg I-TE/g fat, range: 12.1-30.5 pg I-TE/g fat). Increased PCDD/F levels in blood fat seemed to be related mainly to the consumption of self-produced animal products. From the present-day toxicological point of view, none of the subjects examined in this study had a critical body burden of PCDD/F.

Adult↗
PubMed1997

[PCDD/F-content in house dust].

The levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) were determined in house dust samples collected from 22 residential houses located in different areas of Germany. Nine houses were located in an urban and industrial area, one house in a rural and 10 houses in a contaminated residential area near to a former metal reclamation plant. Two house dust samples were collected from two old farm houses, in which large amounts of pentachlorophenol (PCP) containing wood preservatives had been used several years ago. All dust samples were collected from the dust bags of vacuum cleaners and passed through a sieve (mesh: 2.0 mm). Particles < 2.0 mm were used for analysis. The average level of PCDD/F in "normal" house dust was 101 ng I-TEq/kg (range: 7.83-332 ng I-TEq/kg). The predominant congeners and chlorohomologues were OctaCDD followed by HeptaCDD, HeptaCDF and OctaCDF. The average level of PCDD/F in house dust samples collected from a contaminated residential area was 265 ng I-TEq/kg (range: 29.9-1050 ng I-TEq/kg). When compared with "normal" residential houses significantly increased levels of lower chlorinated PCDD/F were noted in the house dust samples from this area. The house dust samples collected from a PCP-treated old farm house were found to contain 1.39 and 11.8 micrograms I-TEq/kg. The chlorohomologues patterns were typical for PCP contaminated with PCDD/F. The present study shows that the levels of PCDD/F in house dust may be used as indicators of indoor contamination by PCDD/F and as reference values for further investigations.

Air Pollutants↗
PubMed1996

Urinary levels of 1-hydroxypyrene, 1-, 2-, 3-, and 4-hydroxyphenanthrene in females living in an industrial area of Germany.

The concentrations of 1-hydroxypyrene (1-HOPYR), and 1-, 2-, 3-, and 4-hydroxyphenanthrene (HOPHE) as metabolites of pyrene and phenanthrene, were measured in urine samples collected from 124 housewives (27 smokers and 97 non-smokers) living in Bottrop, an industrial city located in the Ruhr area in Germany. The urine samples were analyzed by a very sensitive and practical high-performance liquid chromatographic (HPLC) method using a two-column switching technique and a special precolumn packing material followed by fluorescence detection. The polycyclic aromatic hydrocarbon (PAH) metabolites are selectively enrichéd on the precolumn and separated from the matrix. Therefore, laborious clean-up steps were omitted. The above-mentioned PAH metabolites could be detected in all urine samples investigated. Smokers had significantly higher urine concentrations of 1-HOPYR (median 0.48 microgram/g creatinine), 3-HOPHE (median 0.61 microgram/g creatinine), 2-HOPHE (0.41 microgram/g creatinine) and 4-HOPHE (median 0.10 microgram/g creatinine) than non-smokers (median 0.15 microgram/g creatinine, 0.31 microgram/g creatinine, 0.31 microgram/g creatinine and 0.04 microgram/g creatinine, respectively). The study shows that the influence of smoking is of such an order of magnitude that potential environmental exposure to PAH in this highly industrialized area is obscured by smoking habits. Furthermore, it can be concluded that the determination of 1-HOPYR, 1-, 2-, 3-, and 4-HOPHE in urine is a diagnostically useful method for the biological monitoring of persons environmentally exposed to PAH.

Air Pollutants↗
PubMed1996

Levels of PCDD/PCDF in blood fat as indices of the PCDD/PCDF body burden in humans.

The levels of PCDD/F in blood fat are similar to those in body fat and in milk fat of lactating women. Therefore, the levels of PCDD/F in blood fat can be used as an index of the individual PCDD/F body burden in humans. In order to evaluate the PCDD/F background exposure levels of the German population, blood samples collected from 95 subjects (age 12-82 years) living in a rural area of North-West Germany were analysed for PCDD/F. The median 2,3,7,8-TCDD toxicity equivalents (TE) were 40.8 pg I-TE/g blood fat and the 95th percentile was 82.1 pg I-TE/g blood fat. The TE levels in blood fat show a marked increase with age, which reflects the pronounced accumulation of PCDD/F in the human body throughout the entire lifetime. Considering single congeners, significant differences in the age-related increase were noted. Using age-specific reference values derived from this study the levels of PCDD/F in blood fat of individuals environmentally exposed to PCDD/F under different circumstances were evaluated.

Adolescent↗
PubMed1996

[Lead and cadmium content in deciduous teeth of children of Stolberg and other cities of North-Rhine-Westphalia: a chronological trend 1968-1993].

The levels of lead and cadmium were determined in deciduous teeth (incisors only) of children living in Stolberg and some other cities located in North-Rhine-Westfalia, Germany. The Stolberg children were born in 1968-1973 (group 1; n = 103) and 1982/1983 (group 2; n = 103). The other children (n = 109) were born between 1979 and 1986. All teeth were analysed within the same analytical series by atomic absorption spectrometry (AAS). The results show that the average levels of lead and cadmium in milk teeth have decreased significantly in the time period from 1970 to 1990. Considering the Stolberg children the fall of tooth lead was about 50% and the fall of tooth cadmium was about 60%. Children from other cities show a comparable decrease of tooth lead and tooth cadmium. The results indicate that a significant decrease of the lead body burden and cadmium body burden of children and probably also of the general population of Germany has occurred during the last years.

Age Factors↗
PubMed1994

Lead exposure of the child population in Greece.

Lead exposure of the child population was studied in three different areas in Greece: Kalamata which is a rural area of Southern Greece; Tavros, a district of Athens with a considerable industrial activity; and Lavrion, a small city near Athens where a lead-zinc mining and smelting industrial complex has existed for more than 90 years. The results were evaluated with respect to a number of individual, social and environmental variables (i.e. smelter, occupation of the father) especially those concerning the area of Lavrion which is the most heavily polluted area in Greece. The results of this study can be considered as an index for the extent of the lead pollution problem in the named areas of Greece.

Analysis of Variance↗
PubMed1994

[Digoxin content in blood lipids of children, athletes, sports ground attendants and residents after content with dioxin-containing surface slag (Kieselrot)].

In 1991 it was discovered, that a large number of sporting grounds and playgrounds in Germany were covered with a waste slag material from a former copper smelter located at Marsberg, Germany. This material was found to contain high levels of PCDD/F ranging up to 100,000 TE/kg. The objective of the present study was to assess whether subjects sporting on such grounds had elevated levels of PCDD/F in blood. PCDD/F in blood fat was used as an indicator of the PCDD/F body burden. Additionally, six children and seven residents of a contaminated sporting and playground were examined. Generally, the levels of PCDD/F in blood fat were in the range of background levels in all subjects. Taking into account the effect of age, slightly elevated blood levels of PCDD/F were detected in children. The results show that the bioavailability of PCDD/F in the slag material is very low. However, from the preventive point of view children who might ingest slag material by hand-to-mouth-activities, should not play on such contaminated playgrounds.

Adolescent↗
PubMed1993

[Heavy metal pollution of soil and garden products of Stolberg home gardens and lead and cadmium pollution of small farms in Stolberg].

Cadmium, lead and zinc were determined in garden soils and vegetable products from private gardens located in a lead/zinc smelter area (Stolberg, Germany). At the same time lead and cadmium were measured in blood and urine samples collected from 90 garden owners. Inspite of extraordinary high levels of cadmium and lead in garden soils and vegetables, blood lead, blood cadmium and urine cadmium levels were not or only slightly elevated in the gardeners when compared to a reference group of subjects from the same area who did not consume home-grown vegetables and fruits. The results show that high levels of pollutants in soil and vegetables are not necessarily associated with an increased burden of pollutants in the human body, and that the transfer of pollutants from soil to humans might have been overestimated in some cases. Moreover, the results underline the preventive character of the guideline values presently applied with respect to the evaluation of soil contaminants.

Cadmium↗
PubMed1992

[Mercury exposure of the population. IV. Mercury exposure of male dentists, female dentists and dental aides].

Urinary mercury levels were determined in 22 dentists and 46 dental nurses and assistants working in 15 private dental offices in West-Germany. For comparison, urinary mercury levels of 29 subjects without occupational mercury exposure were studied. On average, urinary mercury in dental personnel was higher than in the reference group. Individual mercury levels, however, were all significantly below present occupational exposure limits. Urinary mercury was significantly correlated with the number of amalgam fillings in dental personnel as well as in the reference group. Following administration of Dimaval a significant increase of mercury excretion was observed in both groups. Regarding total exposure to mercury in dental personnel, the contribution of mercury exposure from the occupational environment is of the same order of magnitude as their exposure from their own amalgam fillings. Dental nurses were found to be more exposed than dentists. This finding seems to be related predominantly to the larger number of amalgam fillings in dental nurses.

Adult↗
PubMed1992

[The mercury exposure of the population. III. Mercury mobilisation by DMPS (Dimaval) in subjects with and without amalgam fillings].

The urinary excretion of mercury (per 24 h) was determined in 29 subjects before and after application of DMPS (2.3-dimercapto-1-propane sulfonic acid, 300 mg per os). A 6-7 fold increase of mercury excretion was noted after application of DMPS. Subjects with amalgam fillings excreted significantly more mercury before as well as after application of DMPS than subjects without amalgam fillings. Urinary mercury excretion was significantly correlated with the number of amalgam fillings. About 50% of the variance of urinary mercury can be explained by the number of amalgam fillings. The results show that the release of mercury from amalgam fillings represents the main source of mercury exposure in subjects with amalgam fillings.

Adult↗
PubMed1991

High lead content of deciduous teeth in chronic renal failure.

Lead is suspected to contribute to the progression of kidney disease. Lead content of blood and deciduous teeth was determined in 22 children aged 5-14 years at different stages of chronic renal failure (CRF). In addition, individual lead exposure was estimated from histories. The results were compared with a control group of 20 siblings or neighbours of patients living in the same environment (C1), and to a group of children known to be free of excessive lead exposure (C2). The mean blood lead concentration of patients was normal (mean 2.9 micrograms/dl, range 1.1.-10.1). Mean dental lead content was 2.8, 1.7 and 1.4 micrograms/g in CRF, C1 and C2, respectively. It always exceeded that of healthy peers. Increased dental lead content was associated with a high risk of exposure. It is suggested that both an increased lead uptake and renal dysfunction may contribute to the increased lead burden in children with CRF.

Adolescent↗
PubMed1990

[Exposure to mercury in the population. I. Mercury concentrations in the urine of normal subjects].

The levels of mercury were determined in 24 h urine samples collected from 703 subjects (age 1-79 years) living in the Eastern part of the Ruhr area (West-Germany). The mean HgU level was 0.75 micrograms/l (range less than 0.1-19.3 micrograms/l) and the mean HgU level standardized for creatinine was 0.64 micrograms/g creatinine (range: less than 0.1-27.4 micrograms/g creatinine). The mean mercury excretion per 24 h was 0.48 micrograms in subjects less than 18 years and 0.99 micrograms in subjects greater than 18 years. Females were found to have, on average, higher HgU levels and also a higher excretion of mercury per 24 h than males. Subjects greater than 18 years had significantly higher HgU levels than subjects less than 18 years of age. The effect of age was found to be substantially more pronounced in females than in males. Smoking did not affect the urinary mercury excretion.

Adolescent↗